Special Issue "Corneal Scarring: Wound Healing and Biomaterials"
A special issue of Journal of Functional Biomaterials (ISSN 2079-4983).
Deadline for manuscript submissions: closed (31 August 2012)
Dr. Dimitris Karamichos
Department of Ophthalmology, Schepens Eye Research Institute, Harvard Medical School, 20 Staniford Street, Boston MA 02114, USA
Interests: corneal wound healing; extracellular matrix; biomaterials; growth factors
Over 10 million people worldwide are blind as a result of corneal opacity or scarring. Currently, there are few therapeutic options other than corneal transplantation. One of the hopes for treatment of these patients is the development of an artificial cornea or a compatible biomaterial to replace part or all of the affected area. For well over 200 years, ophthalmologists have been intrigued by the concept of replacing an opaque cornea with an optically clear substitute. These efforts have been slowed by the difficulty in finding a substitute that can replace the exquisitely aligned collagen matrix of the cornea, as well as resist rejection. Several investigations have been made in to the use of plastics to develop an artificial cornea, also termed keratoprosthesis. These keratoprosthesis have enjoyed some success however have not solved the problem. As an alternative to the use of plastics, several investigations have been made to engineer an artificial cornea using natural compounds such as collagens, and to allow corneal cells to secrete their own matrix. The goal of these studies is to develop a synthetic cornea that mimics the native cornea and also integrates into the human eye. It is clearly a huge challenge and the input and effort of various scientific disciplines is vital.
Dr. Dimitris Karamichos
- wound healing
- extracellular matrix
J. Funct. Biomater. 2012, 3(4), 879-894; doi:10.3390/jfb3040879
Received: 7 September 2012; in revised form: 4 December 2012 / Accepted: 5 December 2012 / Published: 10 December 2012| Download PDF Full-text (241 KB) | View HTML Full-text | Download XML Full-text
J. Funct. Biomater. 2012, 3(4), 760-775; doi:10.3390/jfb3040760
Received: 29 August 2012; in revised form: 9 October 2012 / Accepted: 24 October 2012 / Published: 13 November 2012| Download PDF Full-text (6495 KB) | View HTML Full-text | Download XML Full-text
J. Funct. Biomater. 2012, 3(4), 726-744; doi:10.3390/jfb3040726
Received: 27 July 2012; in revised form: 12 September 2012 / Accepted: 17 September 2012 / Published: 17 October 2012| Download PDF Full-text (648 KB) | View HTML Full-text | Download XML Full-text
Review: Control of Scar Tissue Formation in the Cornea: Strategies in Clinical and Corneal Tissue Engineering
J. Funct. Biomater. 2012, 3(3), 642-687; doi:10.3390/jfb3030642
Received: 30 June 2012; in revised form: 27 August 2012 / Accepted: 30 August 2012 / Published: 18 September 2012| Download PDF Full-text (2228 KB) | View HTML Full-text | Download XML Full-text
Article: Experimental Models for Investigating Intra-Stromal Migration of Corneal Keratocytes, Fibroblasts and Myofibroblasts
J. Funct. Biomater. 2012, 3(1), 183-198; doi:10.3390/jfb3010183
Received: 27 January 2012; in revised form: 10 March 2012 / Accepted: 13 March 2012 / Published: 19 March 2012| Download PDF Full-text (2425 KB) | Download XML Full-text | Supplementary Files
Last update: 26 February 2014