J. Funct. Biomater. 2012, 3(3), 642-687; doi:10.3390/jfb3030642
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Control of Scar Tissue Formation in the Cornea: Strategies in Clinical and Corneal Tissue Engineering

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Received: 30 June 2012; in revised form: 27 August 2012 / Accepted: 30 August 2012 / Published: 18 September 2012
(This article belongs to the Special Issue Corneal Scarring: Wound Healing and Biomaterials)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Corneal structure is highly organized and unified in architecture with structural and functional integration which mediates transparency and vision. Disease and injury are the second most common cause of blindness affecting over 10 million people worldwide. Ninety percent of blindness is permanent due to scarring and vascularization. Scarring caused via fibrotic cellular responses, heals the tissue, but fails to restore transparency. Controlling keratocyte activation and differentiation are key for the inhibition and prevention of fibrosis. Ophthalmic surgery techniques are continually developing to preserve and restore vision but corneal regression and scarring are often detrimental side effects and long term continuous follow up studies are lacking or discouraging. Appropriate corneal models may lead to a reduced need for corneal transplantation as presently there are insufficient numbers or suitable tissue to meet demand. Synthetic optical materials are under development for keratoprothesis although clinical use is limited due to implantation complications and high rejection rates. Tissue engineered corneas offer an alternative which more closely mimic the morphological, physiological and biomechanical properties of native corneas. However, replication of the native collagen fiber organization and retaining the phenotype of stromal cells which prevent scar-like tissue formation remains a challenge. Careful manipulation of culture environments are under investigation to determine a suitable environment that simulates native ECM organization and stimulates keratocyte migration and generation.
Keywords: cornea; keratocyte; fibroblast; differentiation; scarring; disease
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MDPI and ACS Style

Wilson, S.L.; El Haj, A.J.; Yang, Y. Control of Scar Tissue Formation in the Cornea: Strategies in Clinical and Corneal Tissue Engineering. J. Funct. Biomater. 2012, 3, 642-687.

AMA Style

Wilson SL, El Haj AJ, Yang Y. Control of Scar Tissue Formation in the Cornea: Strategies in Clinical and Corneal Tissue Engineering. Journal of Functional Biomaterials. 2012; 3(3):642-687.

Chicago/Turabian Style

Wilson, Samantha L.; El Haj, Alicia J.; Yang, Ying. 2012. "Control of Scar Tissue Formation in the Cornea: Strategies in Clinical and Corneal Tissue Engineering." J. Funct. Biomater. 3, no. 3: 642-687.

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