Special Issue "Corneal Disease and Biomaterials"


A special issue of Journal of Functional Biomaterials (ISSN 2079-4983).

Deadline for manuscript submissions: 31 January 2015

Special Issue Editor

Guest Editor
Prof. Dr. Dimitrios Karamichos
Department of Ophthalmology, University of Oklahoma Health Sciences Center, 608 Stanton L. Young Blvd, DMEI PA-409, Oklahoma City, OK 73104, USA
Website: http://www.mei.org/dimitris-karamichos-phd1
E-Mail: dimitrios-karamichos@ouhsc.edu
Phone: +1 405 271 4019
Interests: corneal fibrosis; dystrophies; wound healing; innovative materials; development and implementation of novel materials

Special Issue Information

Dear Colleagues,

Cornea is the transparent front part of the eye that covers the iris, pupil, and anterior chamber. Cornea is a highly organized tissue and responsible for two-thirds of the eye’s total optical power. It is vital therefore to keep the cornea transparent in order to ensure good vision. Partial or complete vision loss may occur upon corneal injury and/or disease. Common corneal diseases and disorders include, but are not limited to: corneal abrasion, corneal dystrophy, corneal ulcer, Fuchs’ dystrophy, keratitis, and keratoconus.
Despite many advances, corneal transplantation remains one of the most common procedures. Approximately 100,000 procedures are performed worldwide every year, and around 10 million people are in need of corneal transplantation. Clearly, alternative solutions are required in order to treat those affected by some kind of corneal disease. Development of in vitro biomaterials and tissue engineering solutions are vital and necessary. Such discoveries can lead to the development of new therapeutic targets and can benefit a huge number of patients with corneal diseases.

Prof. Dr. Dimitrios Karamichos
Guest Edito


Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Functional Biomaterials is an international peer-reviewed Open Access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 300 CHF (Swiss Francs). English correction and/or formatting fees of 250 CHF (Swiss Francs) will be charged in certain cases for those articles accepted for publication that require extensive additional formatting and/or English corrections.


  • cornea
  • tissue engineering
  • corneal fibrosis
  • novel biomaterials
  • therapeutic technologies
  • corneal disease

Published Papers (2 papers)

Download All Papers
Sort by:
Display options:
Select articles Export citation of selected articles as:
Select/unselect all
Displaying article 1-2
p. 50-65
by , , , ,  and
J. Funct. Biomater. 2015, 6(1), 50-65; doi:10.3390/jfb6010050
Received: 15 December 2014 / Accepted: 13 January 2015 / Published: 22 January 2015
Show/Hide Abstract | PDF Full-text (561 KB) | HTML Full-text | XML Full-text
(This article belongs to the Special Issue Corneal Disease and Biomaterials)
p. 111-134
by  and
J. Funct. Biomater. 2014, 5(3), 111-134; doi:10.3390/jfb5030111
Received: 11 August 2014 / Revised: 26 August 2014 / Accepted: 3 September 2014 / Published: 11 September 2014
Show/Hide Abstract | PDF Full-text (777 KB) | HTML Full-text | XML Full-text
(This article belongs to the Special Issue Corneal Disease and Biomaterials)
Select/unselect all
Displaying article 1-2
Select articles Export citation of selected articles as:

Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Type of Paper: Review
Tissue Engineering the Cornea: The Evolution of RAFT
H. J. Levis, A. K. Kureshi, I. Massie, L. Morgan, A. J. Vernon and J. T. Daniels*
: Corneal blindness affects over 10 million people worldwide and current treatment strategies often involve replacement of the defective layer with healthy tissue. Due to a worldwide donor cornea shortage and the absence of suitable biological scaffolds, recent research has focused on the development of tissue engineering techniques to create alternative therapies. This review will detail how we have refined the simple engineering technique of plastic compression of collagen to a process we now call real architecture for 3D tissues (RAFT). The RAFT production process has been standardised, and steps have been taken to consider Good Manufacturing Practice compliance. The evolution of this process has allowed us to create biomimetic epithelial and endothelial tissue equivalents suitable for transplantation and ideal for studying cell-cell interactions in vitro.

Type of Paper: Review
Nanomedicine Approaches for Corneal Diseases
Shyam S. Chaurasia and Rajiv R. Mohan*
Department of Ophthalmology, College of Veterinary Medicine and Mason Eye Institute, 1600 E. Rollins Road, University of Missouri-Columbia, Columbia, MO 65211, USA
Corneal diseases, the third leading cause of global blindness, typically involve inflammation, neovascularization, fibrosis, and loss of transparency. Topical NSAIDs, steroid, antibiotics and tissue transplantation are currently used to treat corneal conditions, however have many limitations including poor efficacy and serious side-effects. Nanoparticle-based molecular medicine has shown great promise to offer novel treatment modalities for corneal diseases. Our laboratory is engaged in the development of nanomedicine approaches for treating corneal defects and restoring clear vision without significant side effects. We have identified plymeric, metallic and hybrid nanoparticles capable of transporting genes into corneal cells to intecept pathologic pathways and processes leading to blindness. This review provides an overview of various nanomaterials properties, applications in drug-delivery, and potential in corneal disease management.

Last update: 4 December 2014

J. Funct. Biomater. EISSN 2079-4983 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert