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J. Funct. Biomater. 2015, 6(2), 277-298; doi:10.3390/jfb6020277

Nanomedicine Approaches for Corneal Diseases

1
Harry S. Truman Memorial Veteran Hospital, Columbia, MO 65201, USA
2
Department of Ophthalmology Veterinary Medicine & Surgery, Columbia, MO 65211, USA
3
Mason Eye Institute, University of Missouri-Columbia, Columbia, MO 65211, USA
4
Singapore Eye Research Institute, 20 College Road, 169856, Singapore
*
Author to whom correspondence should be addressed.
Academic Editor: Dimitrios Karamichos
Received: 10 February 2015 / Revised: 28 April 2015 / Accepted: 28 April 2015 / Published: 30 April 2015
(This article belongs to the Special Issue Corneal Disease and Biomaterials)
View Full-Text   |   Download PDF [4008 KB, uploaded 30 April 2015]   |  

Abstract

Corneal diseases are the third leading cause of blindness globally. Topical nonsteroidal anti-inflammatory drugs (NSAIDs), steroids, antibiotics and tissue transplantation are currently used to treat corneal pathological conditions. However, barrier properties of the ocular surface necessitate high concentration of the drugs applied in the eye repeatedly. This often results in poor efficacy and several side-effects. Nanoparticle-based molecular medicine seeks to overcome these limitations by enhancing the permeability and pharmacological properties of the drugs. The promise of nanomedicine approaches for treating corneal defects and restoring vision without side effects in preclinical animal studies has been demonstrated. Numerous polymeric, metallic and hybrid nanoparticles capable of transporting genes into desired corneal cells to intercept pathologic pathways and processes leading to blindness have been identified. This review provides an overview of corneal diseases, nanovector properties and their applications in drug-delivery and corneal disease management. View Full-Text
Keywords: corneal diseases; infection; scarring; fibrosis; neovascularization; nanoparticles; nanomedicine; nanomaterials; nanodelivery corneal diseases; infection; scarring; fibrosis; neovascularization; nanoparticles; nanomedicine; nanomaterials; nanodelivery
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Chaurasia, S.S.; Lim, R.R.; Lakshminarayanan, R.; Mohan, R.R. Nanomedicine Approaches for Corneal Diseases. J. Funct. Biomater. 2015, 6, 277-298.

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