Special Issue "Quantitative Modelling in Molecular System Bioenergetics"
Deadline for manuscript submissions: closed (15 September 2010)
Dr. Valdur Saks
Laboratory of Bioenergetics, INSERM U884, Joseph Fourier University, Grenoble, France
Phone: +33 4 7663 5627
Fax: +33 4 7651 4218
Interests: bioenergetics; systems biology; biophysics; enzymology; cell physiology
The new Special Issue of IJMS continues description of developments in new area of the research - Molecular System Bioenergetics, which was begun by publication of a book “Molecular System Bioenergetics. Energy for Life” by Wiley-VCH in 2007 (http://www3.interscience.wiley.com/cgi-bin/bookhome/117349267) and followed by publication in 2009 of Special Issue of IJMS “Molecular System Bioenergetics” (http://www.mdpi.com/journal/ijms/special_issues/molecular_system_bioenergetics). The way of life of cells is metabolism by exchanging mass and energy with surrounding medium, and understanding its mechanisms needs knowledge of the complex interactions between cellular systems and components. Understanding of the mechanisms of regulation of metabolic and energy fluxes is one of the important aims of Molecular System Bioenergetics, a part of Systems Biology. An important tool in these investigations is the use of quantitative, mathematical models for description, analysis and prediction of the behavior of the complex, integrated systems. While there is abundant literature on quantitative aspects of Systems Biology, network theories etc, important area of metabolic research is still full of contradictions, especially regarding the mathematical description of intracellular metabolic systems and energy metabolism of the cells. Here, two opposite approaches are used with conflicting results, as it has been described in details in a recent review by Saks et al., Int. J. Mol. Sci. 2008, 9, 751-767. One part of investigators ignores the information of complex cell structure and intracellular interactions; these are not interesting for this Special Issue. The aim of this Issue is discussion of problems of modelling of real intracellular metabolic systems functioning in non-equilibrium steady state, taking into account compartmentation of metabolites and enzymes, metabolic channeling, restrictions of intracellular diffusion, direct interaction of enzymes within multienzyme complexes, formation and behavior of dissipative metabolic networks etc. This is a new challenge for Molecular System Bioenergetics.
Prof. Dr. Valdur Saks
Related Special Issues in 2009
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed Open Access monthly journal published by MDPI.
- mathematical modelling
- cellular bioenergetics
- metabolic channeling
- dissipative metabolic networks
- non-equilibrium steady state kinetics
- feedback regulation
Article: Robustness in Regulatory Interaction Networks. A Generic Approach with Applications at Different Levels: Physiologic, Metabolic and Genetic
Int. J. Mol. Sci. 2009, 10(10), 4437-4473; doi:10.3390/ijms10104437
Received: 15 September 2009; in revised form: 2 October 2009 / Accepted: 14 October 2009 / Published: 19 October 2009| Download PDF Full-text (2016 KB) | Download XML Full-text
Review: Application of the Principles of Systems Biology and Wiener's Cybernetics for Analysis of Regulation of Energy Fluxes in Muscle Cells in Vivo
Int. J. Mol. Sci. 2010, 11(3), 982-1019; doi:10.3390/ijms11030982
Received: 30 January 2010; in revised form: 26 February 2010 / Accepted: 26 February 2010 / Published: 8 March 2010| Download PDF Full-text (1221 KB) | Download XML Full-text
Article: Energetics of Glucose Metabolism: A Phenomenological Approach to Metabolic Network Modeling
Int. J. Mol. Sci. 2010, 11(8), 2921-2961; doi:10.3390/ijms11082921
Received: 6 July 2010; in revised form: 5 August 2010 / Accepted: 6 August 2010 / Published: 12 August 2010| Download PDF Full-text (501 KB) | Download XML Full-text
Review: The Chemical Master Equation Approach to Nonequilibrium Steady-State of Open Biochemical Systems: Linear Single-Molecule Enzyme Kinetics and Nonlinear Biochemical Reaction Networks
Int. J. Mol. Sci. 2010, 11(9), 3472-3500; doi:10.3390/ijms11093472
Received: 15 August 2010 / Accepted: 14 September 2010 / Published: 20 September 2010| Download PDF Full-text (481 KB) | Download XML Full-text
Int. J. Mol. Sci. 2010, 11(9), 3540-3599; doi:10.3390/ijms11093540
Received: 13 August 2010; in revised form: 11 September 2010 / Accepted: 12 September 2010 / Published: 27 September 2010| Download PDF Full-text (872 KB) | Download XML Full-text
Last update: 12 January 2011