Special Issue "Quantitative Modelling in Molecular System Bioenergetics"

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A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry, Molecular Biology and Biophysics".

Deadline for manuscript submissions: closed (15 September 2010)

Special Issue Editor

Guest Editor
Dr. Valdur Saks
Laboratory of Bioenergetics, INSERM U884, Joseph Fourier University, Grenoble, France
E-Mail: valdur.saks@ujf-grenoble.fr
Phone: +33 4 7663 5627
Fax: +33 4 7651 4218
Interests: bioenergetics; systems biology; biophysics; enzymology; cell physiology

Special Issue Information

Dear Colleagues,

The new Special Issue of IJMS continues description of developments in new area of the research - Molecular System Bioenergetics, which was begun by publication of a book “Molecular System Bioenergetics. Energy for Life” by Wiley-VCH in 2007 (http://www3.interscience.wiley.com/cgi-bin/bookhome/117349267) and followed by publication in 2009 of Special Issue of IJMS “Molecular System Bioenergetics” (http://www.mdpi.com/journal/ijms/special_issues/molecular_system_bioenergetics). The way of life of cells is metabolism by exchanging mass and energy with surrounding medium, and understanding its mechanisms needs knowledge of the complex interactions between cellular systems and components. Understanding of the mechanisms of regulation of metabolic and energy fluxes is one of the important aims of Molecular System Bioenergetics, a part of Systems Biology. An important tool in these investigations is the use of quantitative, mathematical models for description, analysis and prediction of the behavior of the complex, integrated systems. While there is abundant literature on quantitative aspects of Systems Biology, network theories etc, important area of metabolic research is still full of contradictions, especially regarding the mathematical description of intracellular metabolic systems and energy metabolism of the cells. Here, two opposite approaches are used with conflicting results, as it has been described in details in a recent review by Saks et al., Int. J. Mol. Sci. 2008, 9, 751-767. One part of investigators ignores the information of complex cell structure and intracellular interactions; these are not interesting for this Special Issue. The aim of this Issue is discussion of problems of modelling of real intracellular metabolic systems functioning in non-equilibrium steady state, taking into account compartmentation of metabolites and enzymes, metabolic channeling, restrictions of intracellular diffusion, direct interaction of enzymes within multienzyme complexes, formation and behavior of dissipative metabolic networks etc. This is a new challenge for Molecular System Bioenergetics.

Prof. Dr. Valdur Saks
Guest Editor

Keywords

  • mathematical modelling
  • metabolism
  • cellular bioenergetics
  • compartmentation
  • metabolic channeling
  • dissipative metabolic networks
  • non-equilibrium steady state kinetics
  • feedback regulation

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Published Papers (5 papers)

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Displaying article 1-5
p. 3540-3599
by
Int. J. Mol. Sci. 2010, 11(9), 3540-3599; doi:10.3390/ijms11093540
Received: 13 August 2010; in revised form: 11 September 2010 / Accepted: 12 September 2010 / Published: 27 September 2010
Show/Hide Abstract | Cited by 6 | PDF Full-text (872 KB) | HTML Full-text | XML Full-text
(This article belongs to the Special Issue Quantitative Modelling in Molecular System Bioenergetics)
p. 3472-3500
by  and
Int. J. Mol. Sci. 2010, 11(9), 3472-3500; doi:10.3390/ijms11093472
Received: 15 August 2010; Accepted: 14 September 2010 / Published: 20 September 2010
Show/Hide Abstract | Cited by 17 | PDF Full-text (481 KB) | HTML Full-text | XML Full-text
(This article belongs to the Special Issue Quantitative Modelling in Molecular System Bioenergetics)
p. 2921-2961
by
Int. J. Mol. Sci. 2010, 11(8), 2921-2961; doi:10.3390/ijms11082921
Received: 6 July 2010; in revised form: 5 August 2010 / Accepted: 6 August 2010 / Published: 12 August 2010
Show/Hide Abstract | Cited by 1 | PDF Full-text (501 KB) | HTML Full-text | XML Full-text
(This article belongs to the Special Issue Quantitative Modelling in Molecular System Bioenergetics)
p. 982-1019
by  and
Int. J. Mol. Sci. 2010, 11(3), 982-1019; doi:10.3390/ijms11030982
Received: 30 January 2010; in revised form: 26 February 2010 / Accepted: 26 February 2010 / Published: 8 March 2010
Show/Hide Abstract | Cited by 12 | PDF Full-text (1221 KB) | HTML Full-text | XML Full-text
(This article belongs to the Special Issue Quantitative Modelling in Molecular System Bioenergetics)
p. 4437-4473
by , , , ,  and
Int. J. Mol. Sci. 2009, 10(10), 4437-4473; doi:10.3390/ijms10104437
Received: 15 September 2009; in revised form: 2 October 2009 / Accepted: 14 October 2009 / Published: 19 October 2009
Show/Hide Abstract | Cited by 8 | PDF Full-text (2016 KB) | HTML Full-text | XML Full-text
(This article belongs to the Special Issue Quantitative Modelling in Molecular System Bioenergetics)
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Last update: 8 August 2014

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