Special Issue "Quantitative Modelling in Molecular System Bioenergetics"
Deadline for manuscript submissions: closed (15 September 2010)
Dr. Valdur Saks
Laboratory of Bioenergetics, INSERM U884, Joseph Fourier University, Grenoble, France
Phone: +33 4 7663 5627
Fax: +33 4 7651 4218
Interests: bioenergetics; systems biology; biophysics; enzymology; cell physiology
The new Special Issue of IJMS continues description of developments in new area of the research - Molecular System Bioenergetics, which was begun by publication of a book “Molecular System Bioenergetics. Energy for Life” by Wiley-VCH in 2007 (http://www3.interscience.wiley.com/cgi-bin/bookhome/117349267) and followed by publication in 2009 of Special Issue of IJMS “Molecular System Bioenergetics” (http://www.mdpi.com/journal/ijms/special_issues/molecular_system_bioenergetics). The way of life of cells is metabolism by exchanging mass and energy with surrounding medium, and understanding its mechanisms needs knowledge of the complex interactions between cellular systems and components. Understanding of the mechanisms of regulation of metabolic and energy fluxes is one of the important aims of Molecular System Bioenergetics, a part of Systems Biology. An important tool in these investigations is the use of quantitative, mathematical models for description, analysis and prediction of the behavior of the complex, integrated systems. While there is abundant literature on quantitative aspects of Systems Biology, network theories etc, important area of metabolic research is still full of contradictions, especially regarding the mathematical description of intracellular metabolic systems and energy metabolism of the cells. Here, two opposite approaches are used with conflicting results, as it has been described in details in a recent review by Saks et al., Int. J. Mol. Sci. 2008, 9, 751-767. One part of investigators ignores the information of complex cell structure and intracellular interactions; these are not interesting for this Special Issue. The aim of this Issue is discussion of problems of modelling of real intracellular metabolic systems functioning in non-equilibrium steady state, taking into account compartmentation of metabolites and enzymes, metabolic channeling, restrictions of intracellular diffusion, direct interaction of enzymes within multienzyme complexes, formation and behavior of dissipative metabolic networks etc. This is a new challenge for Molecular System Bioenergetics.
Prof. Dr. Valdur Saks
- mathematical modelling
- cellular bioenergetics
- metabolic channeling
- dissipative metabolic networks
- non-equilibrium steady state kinetics
- feedback regulation