Protein Crystallography
This special issue belongs to the section "Biochemistry".
Special Issue Information
Dear Colleagues,
In the last decades, X-Ray Diffraction Crystallography emerged as a powerful tool in the study of proteins and other macromolecules at the molecular and atomic levels. According to the Protein Data Bank, approximately 85% of the known protein structures and complexes were determined using crystallographic techniques. It is a fundamental tool to obtain crucial information in Structural Biology and related areas as structure-based drug discovery and design. The combined use of Crystallography and other methods have also shown to be of great help in the understanding of biochemical processes in the living cell. The Special Issue “Protein Crystallography” of IJMS covers this important research area.
Dr. Ricardo Aparicio
Guest Editor
Leading Papers and Reviews
- Dauter, Z. Current state and prospects of macromolecular crystallography. Acta Crystallogr. D Biol. Crystallogr. 2006, 62, 1-11. (Review Article)
- Blundell, T. L.; Sibanda, B. L.; Montalvao, R. W.; Brewerton, S.; Chelliah, V.; Worth, C. L.; Harmer, N. J.; Davies, O.; Burke, D. Structural biology and bioinformatics in drug design: opportunities and challenges for target identification and lead discovery. Philos. Trans. R. Soc. Lond. B Biol. Sci. 2006, 361, 413-423. (Review Article)
- Blundell, T. L.; Patel, S. High-throughput X-ray crystallography for drug discovery. Curr. Opin. Pharmacol. 2004, 4, 490-496. (Review Article)
- Bahar, M.; Ballard, C.; Cohen, S. X.; Cowtan, K. D.; Dodson, E. J.; Emsley, P.; Esnouf, R. M.; Keegan, R.; Lamzin, V.; Langer, G.; Levdikov, V.; Long, F.; Meier, C.; Muller, A.; Murshudov G. N.; Perrakis, A.; Siebold, C.; Stein, N.; Turkenburg, M. G.; Vagin, A. A.; Winn, M.; Winter, G.; Wilson, K. S. SPINE workshop on automated X-ray analysis: a progress report. Acta Crystallogr. D Biol. Crystallogr. 2006, 62, 1170-1183. (Review Article)
- Davis, A. M.; Teague, S. J.; Kleywegt, G. J. Application and limitations of X-ray crystallographic data in structure-based ligand and drug design. Angew. Chem. Int. Ed. Engl. 2003, 42, 2718-2736. (Review Article)
- Kleywegt, G. J.; Jones, T. A. Homo crystallographicus - quo vadis? Structure 2002, 10, 465-472.
- Dauter, Z.; Dauter, M.; Dodson, E. Jolly SAD. Acta Crystallogr. D Biol. Crystallogr. 2002, 58, 494-506.
- EU 3-D Validation Network. Who checks the checkers? Four validation tools applied to eight atomic resolution structures. J. Mol. Biol. 1998, 276, 417-436.
- Russell, R. B.; Alber, F.; Aloy, P.; Davis, F. P.; Korkin, D.; Pichaud, M.; Topf, M.; Sali A. A structural perspective on protein-protein interactions. Curr. Opin. Struct. Biol. 2004, 14, 313-324. (Review Article)
- Sorensen, T. L.; McAuley, K. E.; Flaig, R.; Duke, E. M. New light for science: synchrotron radiation in structural medicine. Trends Biotechnol. 2006, 24, 500-8. (Review Article)
- Lundstrom, K. Structural genomics for membrane proteins. Cell. Mol. Life Sci. 2006, 63, 2597-607. (Review Article)
- Sali, A.; Glaeser, R.; Earnest, T.; Baumeister, W. From words to literature in structural proteomics. Nature 2003, 422, 216-225. (Review Article)
- Chiu, W.; Baker, M. L.; Almo, S. C. Structural biology of cellular machines. Trends Cell Biol. 2006, 16, 144-150. (Review Article)
- Liljas, A. On the complementarity of methods in structural biology. Acta Crystallogr. D Biol. Crystallogr. 2006, 62, 941-945. (Review Article)
- Koch, M. H. J.; Vachette, P.; Svergun, D. I. Small-angle scattering: a view on the properties, structures and structural changes of biological macromolecules in solution. Q. Rev. Biophys. 2003, 36, 147-227. (Review Article)
- Grossmann, J. G. Biological solution scattering: recent achievements and future challenges. J. Appl. Crystallogr. 2007, 40, S217-S222.
- Geerlof, A.; Brown, J.; Coutard, B.; Egloff, M. P.; Enguita, F. J.; Fogg, M. J.; Gilbert, R. J.; Groves, M. R.; Haouz, A.; Nettleship, J. E.; Nordlund, P.; Owens, R. J.; Ruff, M.; Sainsbury, S.; Svergun, D. I.; Wilmanns, M. The impact of protein characterization in structural proteomics. Acta Crystallogr. D Biol. Crystallogr. 2006, 62, 1125-36. (Review Article)
Keywords
- X-ray diffraction Protein Crystallography
- structural biology
- structural genomics
- cloning
- expression
- purification and crystallization
- preliminary crystallographic analysis
- protein structure analysis
- structure-function relationships
- advances in protein crystallization and methodology
- high-throughput methods
- structure-based drug design
- enzymatic reaction mechanisms
- protein molecular mechanisms
- protein-protein interactions
- membrane proteins
- small-angle X-ray scattering of biological macromolecules
- macromolecular complexes
- protein structural databases
- time-resolved Macromolecular Crystallography
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Published Papers
Int. J. Mol. Sci. - ISSN 1422-0067