Special Issue "Protein Crystallography"

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A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry, Molecular Biology and Biophysics".

Deadline for manuscript submissions: closed (30 September 2008)

Special Issue Editor

Guest Editor
Prof. Dr. Ricardo Aparicio
Structural Biology Laboratory, Institute of Chemistry, State University of Campinas (Unicamp), Campinas, SP, CP6154, CEP13084-862, Brazil
Website: http://www.iqm.unicamp.br/departamentos/?p=127&c=129&id=73
E-Mail:
Interests: structural biology; protein crystallography; SAXS

Published Papers

Click here to see a list of 4 papers that have been published in this special issue.

Special Issue Information

Dear Colleagues,

In the last decades, X-Ray Diffraction Crystallography emerged as a powerful tool in the study of proteins and other macromolecules at the molecular and atomic levels. According to the Protein Data Bank, approximately 85% of the known protein structures and complexes were determined using crystallographic techniques. It is a fundamental tool to obtain crucial information in Structural Biology and related areas as structure-based drug discovery and design. The combined use of Crystallography and other methods have also shown to be of great help in the understanding of biochemical processes in the living cell. The special issue “Protein Crystallography” of IJMS covers this important research area.

Dr. Ricardo Aparicio
Guest Editor

Additional Instructions for Authors publishing in the special issue "Protein Crystallography"

  • All of the contributions should be oriented towards biological macromolecules.
  • Data quality should be clearly stated in all cases.
  • Authors are encouraged to follow international standards when publishing structural data.
  • To ensure data deposition and availability for the scientific community, authors of structural communications should follow the guidelines for the deposition and release of macromolecular coordinate and experimental data of the International Union of Crystallography Commission on Biological Macromolecules (Acta Crystallogr. D Biol. Crystallogr. 2000, 56, 2).
  • Coordinates and structure factors must be deposited in the Protein Data Bank and reference codes should be supplied before the paper publication.

Leading Papers and Reviews

  • Dauter, Z. Current state and prospects of macromolecular crystallography. Acta Crystallogr. D Biol. Crystallogr. 2006, 62, 1-11. (Review Article)
  • Blundell, T. L.; Sibanda, B. L.; Montalvao, R. W.; Brewerton, S.; Chelliah, V.; Worth, C. L.; Harmer, N. J.; Davies, O.; Burke, D. Structural biology and bioinformatics in drug design: opportunities and challenges for target identification and lead discovery. Philos. Trans. R. Soc. Lond. B Biol. Sci. 2006, 361, 413-423. (Review Article)
  • Blundell, T. L.; Patel, S. High-throughput X-ray crystallography for drug discovery. Curr. Opin. Pharmacol. 2004, 4, 490-496. (Review Article)
  • Bahar, M.; Ballard, C.; Cohen, S. X.; Cowtan, K. D.; Dodson, E. J.; Emsley, P.; Esnouf, R. M.; Keegan, R.; Lamzin, V.; Langer, G.; Levdikov, V.; Long, F.; Meier, C.; Muller, A.; Murshudov G. N.; Perrakis, A.; Siebold, C.; Stein, N.; Turkenburg, M. G.; Vagin, A. A.; Winn, M.; Winter, G.; Wilson, K. S. SPINE workshop on automated X-ray analysis: a progress report. Acta Crystallogr. D Biol. Crystallogr. 2006, 62, 1170-1183. (Review Article)
  • Davis, A. M.; Teague, S. J.; Kleywegt, G. J. Application and limitations of X-ray crystallographic data in structure-based ligand and drug design. Angew. Chem. Int. Ed. Engl. 2003, 42, 2718-2736. (Review Article)
  • Kleywegt, G. J.; Jones, T. A. Homo crystallographicus - quo vadis? Structure 2002, 10, 465-472.
  • Dauter, Z.; Dauter, M.; Dodson, E. Jolly SAD. Acta Crystallogr. D Biol. Crystallogr. 2002, 58, 494-506.
  • EU 3-D Validation Network. Who checks the checkers? Four validation tools applied to eight atomic resolution structures. J. Mol. Biol. 1998, 276, 417-436.
  • Russell, R. B.; Alber, F.; Aloy, P.; Davis, F. P.; Korkin, D.; Pichaud, M.; Topf, M.; Sali A. A structural perspective on protein-protein interactions. Curr. Opin. Struct. Biol. 2004, 14, 313-324. (Review Article)
  • Sorensen, T. L.; McAuley, K. E.; Flaig, R.; Duke, E. M. New light for science: synchrotron radiation in structural medicine. Trends Biotechnol. 2006, 24, 500-8. (Review Article)
  • Lundstrom, K. Structural genomics for membrane proteins. Cell. Mol. Life Sci. 2006, 63, 2597-607. (Review Article)
  • Sali, A.; Glaeser, R.; Earnest, T.; Baumeister, W. From words to literature in structural proteomics. Nature 2003, 422, 216-225. (Review Article)
  • Chiu, W.; Baker, M. L.; Almo, S. C. Structural biology of cellular machines. Trends Cell Biol. 2006, 16, 144-150. (Review Article)
  • Liljas, A. On the complementarity of methods in structural biology. Acta Crystallogr. D Biol. Crystallogr. 2006, 62, 941-945. (Review Article)
  • Koch, M. H. J.; Vachette, P.; Svergun, D. I. Small-angle scattering: a view on the properties, structures and structural changes of biological macromolecules in solution. Q. Rev. Biophys. 2003, 36, 147-227. (Review Article)
  • Grossmann, J. G. Biological solution scattering: recent achievements and future challenges. J. Appl. Crystallogr. 2007, 40, S217-S222.
  • Geerlof, A.; Brown, J.; Coutard, B.; Egloff, M. P.; Enguita, F. J.; Fogg, M. J.; Gilbert, R. J.; Groves, M. R.; Haouz, A.; Nettleship, J. E.; Nordlund, P.; Owens, R. J.; Ruff, M.; Sainsbury, S.; Svergun, D. I.; Wilmanns, M. The impact of protein characterization in structural proteomics. Acta Crystallogr. D Biol. Crystallogr. 2006, 62, 1125-36. (Review Article)

Submission

All papers should be submitted to ijms@mdpi.org. To be published continuously until the deadline and papers will be listed together at the special issue website.

Submitted papers should not have been published previously, nor be under consideration for publication elsewhere. All papers are refereed through a peer-review process. A guide for authors is available on the Instructions for Authors page. The International Journal of Molecular Sciences is an international peer-reviewed monthly journal published by Molecular Diversity Preservation International.

Open Access publication fees are 800 CHF per paper. English correction fees and/or formatting fees (250 CHF) will be added in certain cases (1050 CHF per paper for those papers that require extensive additional formatting and/or English corrections).

Keywords

X-ray diffraction Protein Crystallography, structural biology, structural genomics, cloning, expression, purification and crystallization, preliminary crystallographic analysis, protein structure analysis, structure-function relationships, advances in protein crystallization and methodology, high-throughput methods, structure-based drug design, enzymatic reaction mechanisms, protein molecular mechanisms, protein-protein interactions, membrane proteins, small-angle X-ray scattering of biological macromolecules, macromolecular complexes, protein structural databases, time-resolved Macromolecular Crystallography

Planned Papers


Last update: 13 October 2008

Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI Publishing, Basel, Switzerland RSS E-Mail Table of Contents Alert