Special Issue "Protein Crystallography"
Deadline for manuscript submissions: closed (30 September 2008)
Prof. Dr. Ricardo Aparicio
Laboratory of Structural Biology and Crystallography Institute of Chemistry, University of Campinas (UNICAMP) Campinas - SP - Brazil CP 6154 - CEP 13083-970
Phone: +55 19 3521 1105
Fax: +55 19 3521 3023
Interests: structural biology; protein crystallography; SAXS
In the last decades, X-Ray Diffraction Crystallography emerged as a powerful tool in the study of proteins and other macromolecules at the molecular and atomic levels. According to the Protein Data Bank, approximately 85% of the known protein structures and complexes were determined using crystallographic techniques. It is a fundamental tool to obtain crucial information in Structural Biology and related areas as structure-based drug discovery and design. The combined use of Crystallography and other methods have also shown to be of great help in the understanding of biochemical processes in the living cell. The special issue “Protein Crystallography” of IJMS covers this important research area.
Dr. Ricardo Aparicio
Additional Instructions for Authors publishing in the special issue "Protein Crystallography"
- All of the contributions should be oriented towards biological macromolecules.
- Data quality should be clearly stated in all cases.
- Authors are encouraged to follow international standards when publishing structural data.
- To ensure data deposition and availability for the scientific community, authors of structural communications should follow the guidelines for the deposition and release of macromolecular coordinate and experimental data of the International Union of Crystallography Commission on Biological Macromolecules (Acta Crystallogr. D Biol. Crystallogr. 2000, 56, 2).
- Coordinates and structure factors must be deposited in the Protein Data Bank and reference codes should be supplied before the paper publication.
Leading Papers and Reviews
- Dauter, Z. Current state and prospects of macromolecular crystallography. Acta Crystallogr. D Biol. Crystallogr. 2006, 62, 1-11. (Review Article)
- Blundell, T. L.; Sibanda, B. L.; Montalvao, R. W.; Brewerton, S.; Chelliah, V.; Worth, C. L.; Harmer, N. J.; Davies, O.; Burke, D. Structural biology and bioinformatics in drug design: opportunities and challenges for target identification and lead discovery. Philos. Trans. R. Soc. Lond. B Biol. Sci. 2006, 361, 413-423. (Review Article)
- Blundell, T. L.; Patel, S. High-throughput X-ray crystallography for drug discovery. Curr. Opin. Pharmacol. 2004, 4, 490-496. (Review Article)
- Bahar, M.; Ballard, C.; Cohen, S. X.; Cowtan, K. D.; Dodson, E. J.; Emsley, P.; Esnouf, R. M.; Keegan, R.; Lamzin, V.; Langer, G.; Levdikov, V.; Long, F.; Meier, C.; Muller, A.; Murshudov G. N.; Perrakis, A.; Siebold, C.; Stein, N.; Turkenburg, M. G.; Vagin, A. A.; Winn, M.; Winter, G.; Wilson, K. S. SPINE workshop on automated X-ray analysis: a progress report. Acta Crystallogr. D Biol. Crystallogr. 2006, 62, 1170-1183. (Review Article)
- Davis, A. M.; Teague, S. J.; Kleywegt, G. J. Application and limitations of X-ray crystallographic data in structure-based ligand and drug design. Angew. Chem. Int. Ed. Engl. 2003, 42, 2718-2736. (Review Article)
- Kleywegt, G. J.; Jones, T. A. Homo crystallographicus - quo vadis? Structure 2002, 10, 465-472.
- Dauter, Z.; Dauter, M.; Dodson, E. Jolly SAD. Acta Crystallogr. D Biol. Crystallogr. 2002, 58, 494-506.
- EU 3-D Validation Network. Who checks the checkers? Four validation tools applied to eight atomic resolution structures. J. Mol. Biol. 1998, 276, 417-436.
- Russell, R. B.; Alber, F.; Aloy, P.; Davis, F. P.; Korkin, D.; Pichaud, M.; Topf, M.; Sali A. A structural perspective on protein-protein interactions. Curr. Opin. Struct. Biol. 2004, 14, 313-324. (Review Article)
- Sorensen, T. L.; McAuley, K. E.; Flaig, R.; Duke, E. M. New light for science: synchrotron radiation in structural medicine. Trends Biotechnol. 2006, 24, 500-8. (Review Article)
- Lundstrom, K. Structural genomics for membrane proteins. Cell. Mol. Life Sci. 2006, 63, 2597-607. (Review Article)
- Sali, A.; Glaeser, R.; Earnest, T.; Baumeister, W. From words to literature in structural proteomics. Nature 2003, 422, 216-225. (Review Article)
- Chiu, W.; Baker, M. L.; Almo, S. C. Structural biology of cellular machines. Trends Cell Biol. 2006, 16, 144-150. (Review Article)
- Liljas, A. On the complementarity of methods in structural biology. Acta Crystallogr. D Biol. Crystallogr. 2006, 62, 941-945. (Review Article)
- Koch, M. H. J.; Vachette, P.; Svergun, D. I. Small-angle scattering: a view on the properties, structures and structural changes of biological macromolecules in solution. Q. Rev. Biophys. 2003, 36, 147-227. (Review Article)
- Grossmann, J. G. Biological solution scattering: recent achievements and future challenges. J. Appl. Crystallogr. 2007, 40, S217-S222.
- Geerlof, A.; Brown, J.; Coutard, B.; Egloff, M. P.; Enguita, F. J.; Fogg, M. J.; Gilbert, R. J.; Groves, M. R.; Haouz, A.; Nettleship, J. E.; Nordlund, P.; Owens, R. J.; Ruff, M.; Sainsbury, S.; Svergun, D. I.; Wilmanns, M. The impact of protein characterization in structural proteomics. Acta Crystallogr. D Biol. Crystallogr. 2006, 62, 1125-36. (Review Article)
All papers should be submitted to firstname.lastname@example.org. To be published continuously until the deadline and papers will be listed together at the special issue website.
Submitted papers should not have been published previously, nor be under consideration for publication elsewhere. All papers are refereed through a peer-review process. A guide for authors is available on the Instructions for Authors page. The International Journal of Molecular Sciences is an international peer-reviewed monthly journal published by MDPI.
Open Access publication fees are 800 CHF per paper. English correction fees and/or formatting fees (250 CHF) will be added in certain cases (1050 CHF per paper for those papers that require extensive additional formatting and/or English corrections).
X-ray diffraction Protein Crystallography, structural biology, structural genomics, cloning, expression, purification and crystallization, preliminary crystallographic analysis, protein structure analysis, structure-function relationships, advances in protein crystallization and methodology, high-throughput methods, structure-based drug design, enzymatic reaction mechanisms, protein molecular mechanisms, protein-protein interactions, membrane proteins, small-angle X-ray scattering of biological macromolecules, macromolecular complexes, protein structural databases, time-resolved Macromolecular Crystallography
Article: Crystallization and Characterization of Galdieria sulphuraria RUBISCO in Two Crystal Forms: Structural Phase Transition Observed in P21 Crystal Form
Int. J. Mol. Sci. 2007, 8(10), 1039-1051; doi:10.3390/i8101039
Received: 13 July 2007; in revised form: 15 October 2007 / Accepted: 16 October 2007 / Published: 23 October 2007| Download PDF Full-text (2578 KB)
Article: Purification and Preliminary Crystallographic Analysis of a New Lys49-PLA2 from B. Jararacussu
Int. J. Mol. Sci. 2008, 9(5), 736-750; doi:10.3390/ijms9050736
Received: 4 February 2008; in revised form: 6 March 2008 / Accepted: 22 March 2008 / Published: 8 May 2008| Download PDF Full-text (750 KB) | Download XML Full-text
Article: Cloning, Expression, Purification and Crystallization of the PR Domain of Human Retinoblastoma Protein-Binding Zinc Finger Protein 1 (RIZ1)
Int. J. Mol. Sci. 2008, 9(6), 943-950; doi:10.3390/ijms9060943
Received: 2 April 2008; in revised form: 28 May 2008 / Accepted: 2 June 2008 / Published: 2 June 2008| Download PDF Full-text (367 KB) | Download XML Full-text
Article: Microseeding – A Powerful Tool for Crystallizing Proteins Complexed with Hydrolyzable Substrates
Int. J. Mol. Sci. 2008, 9(7), 1131-1141; doi:10.3390/ijms9071131
Received: 3 May 2008; in revised form: 5 June 2008 / Accepted: 10 June 2008 / Published: 8 July 2008| Download PDF Full-text (1312 KB) | Download XML Full-text
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Last update: 13 October 2008