Special Issue "Advances in Molecular Immunology"

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A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry, Molecular Biology and Biophysics".

Deadline for manuscript submissions: closed (31 May 2012)

Special Issue Editor

Guest Editor
Prof. Dr. Chris O'Callaghan
Centre for Cellular and Molecular Physiology, Nuffield Department of Clinical Medicine, University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, UK
Website: http://www.ndm.ox.ac.uk/principal-investigators/researcher/chris-o-callaghan
E-Mail: chris.ocallaghan@ndm.ox.ac.uk
Phone: +44 1865 287794
Fax: +44 1865 287787
Interests: immunity; inflammation; vascular disease; gene regulation; protein structure; function

Special Issue Information

Dear Colleagues,

Molecular immunology has provided key insights into the function of the immune system and the physical basis for the recognition of foreign or dangerous material for immune destruction. The molecular approach to immunology was exemplified by early work on antibodies and subsequently by the exposition of T cell recognition in a series of elegant and now classic studies. Detailed molecular work provided the basis for our understanding of antigen presentation by major histocompatibility complex molecules and for the discovery of the T cell receptor. Huge efforts and often painstaking work have gone into the identification of ligands for other immune receptors and vice versa. During each phase of immune discovery, pioneers have used state of the art approaches to achieve what have often been paradigm-shifting results.

The use of increasingly sophisticated technologies has continued to generate exciting results and provide new insights into immune function. From understanding individual molecules, we are now starting to understand how multiple molecular interactions are integrated and how different molecules are configured into larger, functional multimolecular complexes, such as inflammasomes.  Immunological activation events are now understood at increasingly high resolution at the cell surface and within the cell.

A range of advances have contributed to this understanding, including pervasive advances in molecular biology, developments in imaging from the cellular to the atomic level and the rapid expansion of high throughput unbiased approaches, most notably in DNA sequencing. In most of these situations, scientists pursuing biological problems have harnessed new technologies to drive discovery forward. In many cases, this engagement with technology has itself lead to further synergistic developments that accelerate biological discovery further. This special edition will showcase the best molecular immunology to provide readers with an understanding of what the molecular approach has delivered already and its potential for discovery in the future.

Prof. Dr. Chris A O'Callaghan
Guest Editor

Keywords

  • molecular immunology
  • molecular structure
  • molecular interactions
  • inflammation
  • immunity
  • immune recognition
  • immunoreceptor
  • cytokines
  • chemokines

Published Papers (9 papers)

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Displaying article 1-9
p. 7327-7340
by , ,  and
Int. J. Mol. Sci. 2013, 14(4), 7327-7340; doi:10.3390/ijms14047327
Received: 13 December 2012; in revised form: 21 March 2013 / Accepted: 26 March 2013 / Published: 2 April 2013
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(This article belongs to the Special Issue Advances in Molecular Immunology)
p. 13118-13133
by , , , , Jr.,  and
Int. J. Mol. Sci. 2012, 13(10), 13118-13133; doi:10.3390/ijms131013118
Received: 5 July 2012; in revised form: 1 October 2012 / Accepted: 6 October 2012 / Published: 12 October 2012
Show/Hide Abstract | Cited by 1 | PDF Full-text (357 KB) | HTML Full-text | XML Full-text
(This article belongs to the Special Issue Advances in Molecular Immunology)
p. 9826-9844
by  and
Int. J. Mol. Sci. 2012, 13(8), 9826-9844; doi:10.3390/ijms13089826
Received: 8 July 2012; in revised form: 25 July 2012 / Accepted: 30 July 2012 / Published: 7 August 2012
Show/Hide Abstract | Cited by 3 | PDF Full-text (235 KB) | HTML Full-text | XML Full-text
(This article belongs to the Special Issue Advances in Molecular Immunology)
p. 8338-8352
by , , ,  and
Int. J. Mol. Sci. 2012, 13(7), 8338-8352; doi:10.3390/ijms13078338
Received: 1 June 2012; in revised form: 27 June 2012 / Accepted: 29 June 2012 / Published: 4 July 2012
Show/Hide Abstract | Cited by 5 | PDF Full-text (248 KB) | HTML Full-text | XML Full-text
(This article belongs to the Special Issue Advances in Molecular Immunology)
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p. 7629-7647
by , ,  and
Int. J. Mol. Sci. 2012, 13(6), 7629-7647; doi:10.3390/ijms13067629
Received: 16 May 2012; in revised form: 7 June 2012 / Accepted: 14 June 2012 / Published: 21 June 2012
Show/Hide Abstract | Cited by 2 | PDF Full-text (241 KB) | HTML Full-text | XML Full-text
(This article belongs to the Special Issue Advances in Molecular Immunology)
p. 5607-5627
by , , ,  and
Int. J. Mol. Sci. 2012, 13(5), 5607-5627; doi:10.3390/ijms13055607
Received: 13 February 2012; in revised form: 25 April 2012 / Accepted: 28 April 2012 / Published: 10 May 2012
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(This article belongs to the Special Issue Advances in Molecular Immunology)
p. 5674-5699
by , , , , , , , , , , , , , , , , , , , , , , , ,  and
Int. J. Mol. Sci. 2012, 13(5), 5674-5699; doi:10.3390/ijms13055674
Received: 19 April 2012; in revised form: 26 April 2012 / Accepted: 2 May 2012 / Published: 10 May 2012
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(This article belongs to the Special Issue Advances in Molecular Immunology)
p. 2985-3008
by , , , , , , ,  and
Int. J. Mol. Sci. 2012, 13(3), 2985-3008; doi:10.3390/ijms13032985
Received: 13 January 2012; in revised form: 22 February 2012 / Accepted: 24 February 2012 / Published: 6 March 2012
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(This article belongs to the Special Issue Advances in Molecular Immunology)
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p. 506-515
by , , , , ,  and
Int. J. Mol. Sci. 2012, 13(1), 506-515; doi:10.3390/ijms13010506
Received: 30 November 2011; in revised form: 22 December 2011 / Accepted: 22 December 2011 / Published: 4 January 2012
Show/Hide Abstract | Cited by 2 | PDF Full-text (176 KB) | HTML Full-text | XML Full-text | Supplementary Files
(This article belongs to the Special Issue Advances in Molecular Immunology)
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Last update: 26 February 2014

Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert