Special Issue "Advances in Molecular Immunology"
Deadline for manuscript submissions: closed (31 May 2012)
Prof. Dr. Chris O'Callaghan
Centre for Cellular and Molecular Physiology, Nuffield Department of Clinical Medicine, University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, UK
Phone: +44 1865 287794
Fax: +44 1865 287787
Interests: immunity; inflammation; vascular disease; gene regulation; protein structure; function
Molecular immunology has provided key insights into the function of the immune system and the physical basis for the recognition of foreign or dangerous material for immune destruction. The molecular approach to immunology was exemplified by early work on antibodies and subsequently by the exposition of T cell recognition in a series of elegant and now classic studies. Detailed molecular work provided the basis for our understanding of antigen presentation by major histocompatibility complex molecules and for the discovery of the T cell receptor. Huge efforts and often painstaking work have gone into the identification of ligands for other immune receptors and vice versa. During each phase of immune discovery, pioneers have used state of the art approaches to achieve what have often been paradigm-shifting results.
The use of increasingly sophisticated technologies has continued to generate exciting results and provide new insights into immune function. From understanding individual molecules, we are now starting to understand how multiple molecular interactions are integrated and how different molecules are configured into larger, functional multimolecular complexes, such as inflammasomes. Immunological activation events are now understood at increasingly high resolution at the cell surface and within the cell.
A range of advances have contributed to this understanding, including pervasive advances in molecular biology, developments in imaging from the cellular to the atomic level and the rapid expansion of high throughput unbiased approaches, most notably in DNA sequencing. In most of these situations, scientists pursuing biological problems have harnessed new technologies to drive discovery forward. In many cases, this engagement with technology has itself lead to further synergistic developments that accelerate biological discovery further. This special edition will showcase the best molecular immunology to provide readers with an understanding of what the molecular approach has delivered already and its potential for discovery in the future.
Prof. Dr. Chris A O'Callaghan
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed Open Access monthly journal published by MDPI.
- molecular immunology
- molecular structure
- molecular interactions
- immune recognition
Int. J. Mol. Sci. 2012, 13(1), 506-515; doi:10.3390/ijms13010506
Received: 30 November 2011; in revised form: 22 December 2011 / Accepted: 22 December 2011 / Published: 4 January 2012| Download PDF Full-text (176 KB) | Download XML Full-text | Supplementary Files
Article: BDMC33, A Curcumin Derivative Suppresses Inflammatory Responses in Macrophage-Like Cellular System: Role of Inhibition in NF-κB and MAPK Signaling Pathways
Int. J. Mol. Sci. 2012, 13(3), 2985-3008; doi:10.3390/ijms13032985
Received: 13 January 2012; in revised form: 22 February 2012 / Accepted: 24 February 2012 / Published: 6 March 2012| Download PDF Full-text (1564 KB) | Download XML Full-text
Article: Modification of MCF-10A Cells with Pioglitazone and Serum-Rich Growth Medium Increases Soluble Factors in the Conditioned Medium, Likely Reducing BT-474 Cell Growth
Int. J. Mol. Sci. 2012, 13(5), 5607-5627; doi:10.3390/ijms13055607
Received: 13 February 2012; in revised form: 25 April 2012 / Accepted: 28 April 2012 / Published: 10 May 2012| Download PDF Full-text (669 KB) | Download XML Full-text
Int. J. Mol. Sci. 2012, 13(5), 5674-5699; doi:10.3390/ijms13055674
Received: 19 April 2012; in revised form: 26 April 2012 / Accepted: 2 May 2012 / Published: 10 May 2012| Download PDF Full-text (635 KB) | Download XML Full-text
Int. J. Mol. Sci. 2012, 13(6), 7629-7647; doi:10.3390/ijms13067629
Received: 16 May 2012; in revised form: 7 June 2012 / Accepted: 14 June 2012 / Published: 21 June 2012| Download PDF Full-text (241 KB) | Download XML Full-text
Review: Role of Endoplasmic Reticulum Aminopeptidases in Health and Disease: from Infection to Cancer
Int. J. Mol. Sci. 2012, 13(7), 8338-8352; doi:10.3390/ijms13078338
Received: 1 June 2012; in revised form: 27 June 2012 / Accepted: 29 June 2012 / Published: 4 July 2012| Download PDF Full-text (248 KB) | Download XML Full-text
Int. J. Mol. Sci. 2012, 13(8), 9826-9844; doi:10.3390/ijms13089826
Received: 8 July 2012; in revised form: 25 July 2012 / Accepted: 30 July 2012 / Published: 7 August 2012| Download PDF Full-text (235 KB) | Download XML Full-text
Article: Inhibition of Enzyme Activity of Rhipicephalus (Boophilus) microplus Triosephosphate Isomerase and BME26 Cell Growth by Monoclonal Antibodies
Int. J. Mol. Sci. 2012, 13(10), 13118-13133; doi:10.3390/ijms131013118
Received: 5 July 2012; in revised form: 1 October 2012 / Accepted: 6 October 2012 / Published: 12 October 2012| Download PDF Full-text (357 KB) | Download XML Full-text
Article: A Role for Protein Phosphatase 2A in Regulating p38 Mitogen Activated Protein Kinase Activation and Tumor Necrosis Factor-Alpha Expression during Influenza Virus Infection
Int. J. Mol. Sci. 2013, 14(4), 7327-7340; doi:10.3390/ijms14047327
Received: 13 December 2012; in revised form: 21 March 2013 / Accepted: 26 March 2013 / Published: 2 April 2013| Download PDF Full-text (745 KB) | Download XML Full-text | Supplementary Files
Last update: 18 May 2012