Special Issue "Mechanism of Action and Applications of Cytokines in Immunotherapy"


A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Diagnostics".

Deadline for manuscript submissions: 15 November 2014

Special Issue Editor

Guest Editor
Prof. Dr. Kamal D. Moudgil
Department of Microbiology and Immunology, University of Maryland School of Medicine, 685 W. Baltimore Street, HSF-1, Suite 380 Baltimore, MD 21201, USA
Website: http://medschool.umaryland.edu/FACULTYRESEARCHPROFILE/viewprofile.aspx?id=5647
E-Mail: kmoud001@umaryland.edu
Interests: autoimmunity; arthritis; immune regulation; cytokines; antigen processing and presentation; natural products; targeted therapy

Special Issue Information

Dear Colleagues,

Cytokines can be produced by a wide variety of cell types, including lymphocytes, myeloid cells, endothelial cells, and epithelial cells under appropriate stimuli.  Cytokines mediate diverse cellular, biochemical and molecular responses in health as well as during infection and other pathophysiological situations, including tumors and autoimmune diseases. Certain cytokines induce inflammation and tissue damage, whereas others attempt to suppress inflammation and facilitate tissue repair or recovery. Accordingly, cytokines have been broadly categorized as pro-inflammatory or anti-inflammatory in nature. Further, different cytokines may reveal cooperative or antagonistic attributes in the course of immune dysregulation, cell death, and other pathological events. In the past decade or two, many new cytokines and effector/regulatory lymphocyte subsets have been unveiled. Also described are new subsets of macrophages and other myeloid cells. These advances have prompted an enthusiastic search for the mechanism of action of the newer cytokines and their inter-relationships with previously well-known (older) cytokines. The emerging information, in turn, has stimulated the development of novel cytokine-based strategies for therapeutic purposes. For example, a spectrum of biologics is either in use or under development for the treatment of various autoimmune diseases. Similarly, strategies for modulation of cellular/ cytokine activity to enhance anti-tumor immunity are being developed. This special issue discusses the mechanism of action and applications of cytokines for immunotherapeutic purposes.

Prof. Dr. Kamal D. Moudgil
Guest Editor


Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed Open Access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1600 CHF.


  • arthritis
  • autoimmunity
  • biologics
  • cancer
  • cytokines
  • immunotherapy
  • infection
  • interferons
  • lupus
  • lymphokines
  • multiple sclerosis
  • rheumatoid arthritis
  • tumors
  • virus

Published Papers (4 papers)

by , ,  and
Int. J. Mol. Sci. 2014, 15(8), 14632-14648; doi:10.3390/ijms150814632
Received: 20 June 2014; in revised form: 14 July 2014 / Accepted: 11 August 2014 / Published: 21 August 2014
Show/Hide Abstract | PDF Full-text (725 KB) | XML Full-text

by ,  and
Int. J. Mol. Sci. 2014, 15(8), 14313-14331; doi:10.3390/ijms150814313
Received: 12 June 2014; in revised form: 29 July 2014 / Accepted: 1 August 2014 / Published: 18 August 2014
Show/Hide Abstract | PDF Full-text (3887 KB) | XML Full-text | Supplementary Files

by , , , , , ,  and
Int. J. Mol. Sci. 2014, 15(4), 5508-5521; doi:10.3390/ijms15045508
Received: 24 December 2013; in revised form: 25 February 2014 / Accepted: 6 March 2014 / Published: 31 March 2014
Show/Hide Abstract | PDF Full-text (694 KB) | HTML Full-text | XML Full-text

by , , , , , , ,  and
Int. J. Mol. Sci. 2014, 15(3), 4104-4125; doi:10.3390/ijms15034104
Received: 13 December 2013; in revised form: 6 February 2014 / Accepted: 14 February 2014 / Published: 7 March 2014
Show/Hide Abstract | PDF Full-text (466 KB) | HTML Full-text | XML Full-text | Supplementary Files

Last update: 14 March 2014

Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert