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Int. J. Mol. Sci. 2015, 16(10), 24194-24218; doi:10.3390/ijms161024194

Cytokines and MicroRNAs as Candidate Biomarkers for Systemic Lupus Erythematosus

Department of Biochemistry and Molecular Biology, National Institute of Geriatrics, Rheumatology and Rehabilitation, Warsaw 02-637, Poland
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Author to whom correspondence should be addressed.
Academic Editor: Kamal D. Moudgil
Received: 22 July 2015 / Revised: 10 September 2015 / Accepted: 25 September 2015 / Published: 13 October 2015
(This article belongs to the Special Issue Mechanism of Action and Applications of Cytokines in Immunotherapy)
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Abstract

Systemic lupus erythematosus (SLE) is a systemic autoimmune disease, with varied course and symptoms. Its etiology is very complex and not clearly understood. There is growing evidence of the important role of cytokines in SLE pathogenesis, as well as their utility as biomarkers and targets in new therapies. Other potential new SLE biomarkers are microRNAs. Recently, over one hundred different microRNAs have been demonstrated to have a significant impact on the immune system. Various alterations in these microRNAs, associated with disease pathogenesis, have been described. They influence the signaling pathways and functions of immune response cells. Here, we aim to review the emerging new data on SLE etiology and pathogenesis. View Full-Text
Keywords: SLE; biomarkers; microRNA; cytokines SLE; biomarkers; microRNA; cytokines
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Stypińska, B.; Paradowska-Gorycka, A. Cytokines and MicroRNAs as Candidate Biomarkers for Systemic Lupus Erythematosus. Int. J. Mol. Sci. 2015, 16, 24194-24218.

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