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Int. J. Mol. Sci. 2015, 16(8), 18778-18795; doi:10.3390/ijms160818778

New Immunosuppressive Therapies in Uveitis Treatment

1
Instituto de Ciencias Biomédicas, Universidad CEU Cardenal Herrera, Valencia 46113, Spain
2
Oftalmología Médica, Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana, Valencia 46020, Spain
*
Author to whom correspondence should be addressed.
Academic Editor: Kamal D. Moudgil
Received: 29 June 2015 / Revised: 3 August 2015 / Accepted: 6 August 2015 / Published: 11 August 2015
(This article belongs to the Special Issue Mechanism of Action and Applications of Cytokines in Immunotherapy)
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Abstract

Uveitis is an inflammatory process that initially starts in the uvea, but can also affect other adjacent eye structures, and is currently the fourth cause of blindness in developed countries. Corticoids are probably the most widespread treatment, but resorting to other immunosuppressive treatments is a frequent practice. Since the implication of different cytokines in uveitis has been well demonstrated, the majority of recent treatments for this disease include inhibitors or antibodies against these. Nevertheless, adequate treatment for each uveitis type entails a difficult therapeutic decision as no clear recommendations are found in the literature, despite the few protocolized clinical assays and many case-control studies done. This review aims to present, in order, the mechanisms and main indications of the most modern immunosuppressive drugs against cytokines. View Full-Text
Keywords: uveitis; corticoids; cytokines; antibody; immunosuppressive uveitis; corticoids; cytokines; antibody; immunosuppressive
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Mérida, S.; Palacios, E.; Navea, A.; Bosch-Morell, F. New Immunosuppressive Therapies in Uveitis Treatment. Int. J. Mol. Sci. 2015, 16, 18778-18795.

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