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Int. J. Mol. Sci. 2015, 16(2), 2851-2863; doi:10.3390/ijms16022851

Interleukin-27 in T Cell Immunity

1
Department of Allergy and Rheumatology, Graduate School of Medicine, the University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan
2
Max Planck-The University of Tokyo Center for Integrative Inflammology, the University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo 153-8505, Japan
*
Author to whom correspondence should be addressed.
Academic Editor: Kamal D. Moudgil
Received: 27 December 2014 / Revised: 19 January 2015 / Accepted: 22 January 2015 / Published: 27 January 2015
(This article belongs to the Special Issue Mechanism of Action and Applications of Cytokines in Immunotherapy)
View Full-Text   |   Download PDF [1101 KB, uploaded 27 January 2015]   |  

Abstract

Interleukin (IL)-27, a member of IL-12/IL-23 heterodimeric family of cytokines, has pleiotropic properties that can enhance or limit immune responses. IL-27 acts on various cell types, including T cells, B cells, macrophages, dendritic cells, natural killer (NK) cells and non-hematopoietic cells. Intensive studies have been conducted especially on T cells, revealing that various subsets of T cells respond uniquely to IL-27. IL-27 induces expansion of Th1 cells by activating signal transducer and activator of transcription (STAT) 1-mediated T-bet signaling pathway. On the other hand, IL-27 suppresses immune responses through inhibition of the development of T helper (Th) 17 cells and induction of IL-10 production in a STAT1- and STAT3-dependent manner. IL-27 is a potentially promising cytokine for therapeutic approaches on various human diseases. Here, we provide an overview of the biology of IL-27 related to T cell subsets, its structure, and production mechanism. View Full-Text
Keywords: IL-27; IL-27p28; Ebi3; T cell subset IL-27; IL-27p28; Ebi3; T cell subset
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Iwasaki, Y.; Fujio, K.; Okamura, T.; Yamamoto, K. Interleukin-27 in T Cell Immunity. Int. J. Mol. Sci. 2015, 16, 2851-2863.

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