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Novel Drug Delivery Systems Based on Nanocapsules
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Novel Drug Delivery Systems Based on Nanocapsules

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Materials Science".

Deadline for manuscript submissions: closed (31 October 2022) | Viewed by 2414

Special Issue Editor

Dr. Young-IL Jeong

E-Mail Website
Guest Editor
Department of Dental Materials, College of Dentistry, Chosun University, Gwangju 61452, Republic of Korea
Interests: nanoparticle-based drug targeting against cancer; nanomedicine-based drug delivery system across blood-brain barrier; nanomedicine for Alzheimer's disease
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Nanocapsule-based drug delivery systems have been extensively investigated in the various fields of biomedical science. Nanocapsules are defined as nano-dimensional vehicles for the encapsulation of bioactive molecules. Since nanocapsules have a huge surface area and their surfaces can be modified with specific molecules, they can be used to deliver bioactive molecules to specific cells or tissues and respond to the abnormal physiological statuses of disease. For example, the release rate of an anticancer drug from a nanocapsule can be accelerated under the abnormal physological characteristics of tumor tissues such as acidic pH, increased redox status, increased expression of proteolytic enzymes, and higher expression of various receptors. Furthermore, nanocapsules are useful devices for the theranostic purposes of malignant disorders. In this Special Issue, we will focus on nanocapsule-based novel drug delivery systems for application in the therapy or diagnosis of various incurable diseases.

Topics of interest for this Special Issue include, but are not limited to, the following:

  • Stimuli-sensitive drug delivery system based on nanocapsules;
  • Nanocapsule-based diagnosis and therapy of malignant disorders;
  • Nanocapsulation of hydrophilic/hydrophobic drugs;
  • Nanocapsules for controlled release of drugs;
  • Nanocapsules for gene delivery;
  • Nanocapsule-based vaccines for pandemic diseases.

All types of articles including, original research and reviews, are welcome.

Dr. Young-IL Jeong
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanocapsule
  • drug delivery system
  • stimuli-sensitive
  • malignant disorder
  • controlled release of bioactive molecules
  • cancer drug delivery
  • nano-vaccine
  • gene delivery

Published Papers (1 paper)

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Research

17 pages, 5218 KiB  
Article
CD44 Receptor-Mediated/Reactive Oxygen Species-Sensitive Delivery of Nanophotosensitizers against Cervical Cancer Cells
by Jieun Yoon, Howard Kim, Young-IL Jeong and Hoe Saeng Yang
Int. J. Mol. Sci. 2022, 23(7), 3594; https://doi.org/10.3390/ijms23073594 - 25 Mar 2022
Cited by 8 | Viewed by 2072
Abstract
Stimulus-sensitive, nanomedicine-based photosensitizer delivery has an opportunity to target tumor tissues since oxidative stress and the expression of molecular proteins, such as CD44 receptors, are elevated in the tumor microenvironment. The aim of this study is to investigate the CD44 receptor- and reactive [...] Read more.
Stimulus-sensitive, nanomedicine-based photosensitizer delivery has an opportunity to target tumor tissues since oxidative stress and the expression of molecular proteins, such as CD44 receptors, are elevated in the tumor microenvironment. The aim of this study is to investigate the CD44 receptor- and reactive oxygen species (ROS)-sensitive delivery of nanophotosensitizers of chlorin e6 (Ce6)-conjugated hyaluronic acid (HA) against HeLa human cervical cancer cells. For the synthesis of nanophotosensitizers, thioketal diamine was conjugated with the carboxyl group in HA and then the amine end group of HA-thioketal amine conjugates was conjugated again with Ce6 (Abbreviated as HAthCe6). The HAthCe6 nanophotosensitizers were of small diameter, with sizes less than 200. Their morphology was round-shaped in the observations using a transmission electron microscope (TEM). The HAthCe6 nanophotosensitizers responded to oxidative stress-induced changes in size distribution when H2O2 was added to the nanophotosensitizer aqueous solution, i.e., their monomodal distribution pattern at 0 mM H2O2 was changed to dual- and/or multi-modal distribution patterns at higher concentrations of H2O2. Furthermore, the oxidative stress induced by the H2O2 addition contributed to the disintegration of HAthCe6 nanophotosensitizers in morphology, and this phenomenon accelerated the release rate of Ce6 from nanophotosensitizers. In a cell culture study using HeLa cells, nanophotosensitizers increased Ce6 uptake ratio, ROS generation and PDT efficacy compared to free Ce6. Since HA specifically bonds with the CD44 receptor of cancer cells, the pretreatment of free HA against HeLa cells decreased the Ce6 uptake ratio, ROS generation and PDT efficacy of HAthCe6 nanophotosensitizers. These results indicated that intracellular delivery of HAthCe6 nanophotosensitizers can be controlled by the CD44 receptor-mediated pathway. Furthermore, these phenomena induced CD44 receptor-controllable ROS generation and PDT efficacy by HAthCe6 nanophotosensitizers. During in vivo tumor imaging using HeLa cells, nanophotosensitizer administration showed that the fluorescence intensity of tumor tissues was relatively higher than that of other organs. When free HA was pretreated, the fluorescence intensity of tumor tissue was relatively lower than those of other organs, indicating that HAthCe6 nanophotosensitizers have CD44 receptor sensitivity and that they can be delivered by receptor-specific manner. We suggest that HAthCe6 nanophotosensitizers are promising candidates for PDT in cervical cancer. Full article
(This article belongs to the Special Issue Novel Drug Delivery Systems Based on Nanocapsules)
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