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Biochemical Processes in the Therapy of Neurological Diseases: New Challenges and Opportunities

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: closed (28 February 2023) | Viewed by 4089

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Guest Editor
Department of Pharmacy, University "G. d'Annunzio" of Chieti-Pescara, Via dei Vestini 31, 66100 Chieti, Italy
Interests: medicinal chemistry; synthesis and biological evaluation of new small molecules for the therapy of cancer; inflammatory diseases and infections; extraction of bioactive compounds from natural sources
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Special Issue Information

Dear Colleagues,

Neurological diseases are disorders that can affect the central or the peripheral nervous systems and can impair the brain, spinal cord, peripheral nerve or neuromuscular function. They include amyotrophic lateral sclerosis, Parkinson’s disease, Alzheimer’s disease, and autism spectrum disorder. Many specific causes can lead to neurological disorders such as tumors, degeneration, trauma, infections or structural defects, lifestyle or environmental health problems, with the involvement of different biochemical processes.

The aim of this Special Issue is to collect papers describing the most innovative studies shedding light on the biochemical events involved in the development of neurological diseases. Both research and review articles are welcome, and they can be focused on the comprehension of the basis, detection, and treatment of neurological diseases as well as on the development of new therapeutic agents.

Dr. Cristina Maccallini
Guest Editor

Manuscript Submission Information

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Keywords

  • the molecular basis of biological processes
  • neurological diseases
  • Parkinson’s disease
  • Alzheimer’s disease

Published Papers (1 paper)

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Review

16 pages, 860 KiB  
Review
Fabry Disease and Central Nervous System Involvement: From Big to Small, from Brain to Synapse
by Elisenda Cortés-Saladelafont, Julián Fernández-Martín and Saida Ortolano
Int. J. Mol. Sci. 2023, 24(6), 5246; https://doi.org/10.3390/ijms24065246 - 9 Mar 2023
Cited by 5 | Viewed by 3683
Abstract
Fabry disease (FD) is an X-linked lysosomal storage disorder (LSD) secondary to mutations in the GLA gene that causes dysfunctional activity of lysosomal hydrolase α-galactosidase A and results in the accumulation of globotriaosylceramide (Gb3) and globotriaosylsphingosine (lyso-Gb3). The endothelial accumulation of these substrates [...] Read more.
Fabry disease (FD) is an X-linked lysosomal storage disorder (LSD) secondary to mutations in the GLA gene that causes dysfunctional activity of lysosomal hydrolase α-galactosidase A and results in the accumulation of globotriaosylceramide (Gb3) and globotriaosylsphingosine (lyso-Gb3). The endothelial accumulation of these substrates results in injury to multiple organs, mainly the kidney, heart, brain and peripheral nervous system. The literature on FD and central nervous system involvement is scarce when focusing on alterations beyond cerebrovascular disease and is nearly absent in regard to synaptic dysfunction. In spite of that, reports have provided evidence for the CNS’ clinical implications in FD, including Parkinson’s disease, neuropsychiatric disorders and executive dysfunction. We aim to review these topics based on the current available scientific literature. Full article
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