Molecular Alterations in GastroIntestinal Pre-invasive Lesions
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: closed (31 December 2021) | Viewed by 30719
Special Issue Editors
Interests: gastrointestinal pathology; gastric cancer
Special Issues, Collections and Topics in MDPI journals
Interests: colorectal cancer; gastric cancer; dysplasia; molecular carcinogenesis; predictive biomarkers
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear colleguaes,
The relatively recent comprehensive molecular characterization of gastrointestinal tumors has demonstrated that similar oncogenetic pathways are shared among different types of cancers. This represents the biological rationale for the development and introduction into clinical practice of targeted therapies and for the optimization of the already available chemotherapeutic drugs. Moreover, significant intra-tumor genomic and epigenomic heterogeneity has been observed, resulting in the identification of new specific and sensitive predictive and prognostic biomarkers and in innovative molecular classifications based on gene expression profiling. Despite these important information, complete molecular data on pre-invasive lesions of the gastrointestinal tract are still limited, significantly affecting the diagnostic process and treatment of gastrointestinal “early” lesions. The research topic aims to study: (i) the clinico-pathological features and their matched molecular characteristics distinguishing pre-invasive (early) gastrointestinal lesions; (ii) the identification of novel molecular markers, which can be useful in the identification of the neoplastic precursors/preinvasive lesions; (iii) the identification of novel molecular biomarkers to be implemented in the secondary prevention strategies of invasive gastrointestinal tumors.
Prof. Dr. Luca Saragoni
Prof. Dr. Matteo Fassan
Guest Editors
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Keywords
- gastrointestinal cancer
- early diagnosis
- molecular markers
- non-invasive treatments.
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