Modeling Human Biological Pathways in Health, Aging and Disease: The Drosophila Paradigm - in Memory of Professor Suzanne Eaton (1959-2019)
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Genetics and Genomics".
Deadline for manuscript submissions: closed (31 May 2022) | Viewed by 38247
Special Issue Editors
Interests: development; Drosophila models of human diseases; oogenesis; metabolic disorders; neurological pathologies; programmed cell death; proteasome
Special Issues, Collections and Topics in MDPI journals
Interests: development; cancer; chemotherapy; metastasis; programmed cell death; metabolism; Drosophila aging; brain signaling; proteasome
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear colleagues,
Drosophila melanogaster, with its powerful transgenic technology that enables scientists to drive or silence the expression of a gene in a spatial and/or temporal manner, is now established as one of the most sophisticated model organisms for the in vivo investigation of mechanisms regulating, among others, cell differentiation, gene regulation, and aging.
Furthermore, the high level of structural and functional conservation in many fundamental biological processes between humans and flies, and the fact that approximately 75% of all known human disease genes have functional fly homologues, render Drosophila an ideal model for understanding the molecular mechanisms of human diseases, including malignancies. Hence, Drosophila has been effectively used for drug screenings and target discoveries, as well as for the study of various pathological conditions, such as metabolic disorders, neurodegenerative diseases, cardiovascular diseases, aging, and cancer.
Recent research in Drosophila gives special emphasis to the large-scale screening of candidate genes identified from patient genomic sequencing studies aiming at the identification of novel druggable targets for personalized medicine schemes.
For this Special Issue, we welcome original research articles and reviews by experts in this field, whose contribution will provide novel insights into the outlined research areas.
Dr. Athanassios D. Velentzas
Dr. Dimitrios J. Stravopodis
Guest Editors
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Keywords
- Drosophila melanogaster
- Human disease model
- Neurodegenerative diseases
- Metabolic disorders
- Diabetes
- Cardiovascular diseases
- Inflammatory disorders
- Cancer model
- Epigenetic dysregulation
- Aging
- Stem cell maintenance
- Fertility
- Programmed cell death
- Cell differentiation
- Gene regulation
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