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Resveratrol: Improving Human Health and Preventing Diseases
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Resveratrol: Improving Human Health and Preventing Diseases

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: closed (28 February 2024) | Viewed by 4652

Special Issue Editor

Dr. José Díaz-Chávez

E-Mail Website
Guest Editor
1. Instituto Nacional de Cancerología (INCAN), Avenida San Fernando No. 22, Sección XVI Tlalpan, Ciudad de México 14080, Mexico
2. Unidad de Investigación Biomédica en Cáncer, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México (UNAM), Coyoacán, Ciudad de México 04510, Mexico
Interests: resveratrol; cancer; DNA repair
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Resveratrol (RV) is a natural phenol found in red grapes, mulberries, peanuts, wine, and tea, and it can be extracted from red wine during the fermentation of grape skin. The mechanism by which RV exerts favorable effects is related to the induction of genes for oxidative phosphorylation and mitochondrial biogenesis. It has been reported that RV plays a role as an anti-inflammatory, antioxidant, and antiviral, and exerts anticancer activities through many different mechanisms. Patients with higher anxiety traits, depression, and fatigue showed a distinct metabolic profile, indicative of a different energy homeostasis, hormonal metabolism, and gut microbial activity. The daily consumption of RV resulted in a significant modification in the microbial metabolism, with potential long-term health consequences. A human intervention study indicated that the consumption of RV increased the prevalence of Enterococcus, Prevotella, and Bacterioides uniformis. Several beneficial effects have been observed in human beings, but other studies are necessary to continue with the scientific research in this field. Indeed, new knowledge concerning the “Health Benefits of Resveratrol” could enable the development of novel functional foods or nutraceuticals, incorporating resveratrol, suitable for preventing or treating diseases, such as cancer, cardiovascular diseases, obesity, dyslipidemia, insulin resistance and diabetes, liver diseases, and other disorders.

Dr. José Díaz-Chávez
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • resveratrol supplementation
  • resveratrol metabolites
  • sirtuins
  • aging
  • epigenetic
  • benefits in chronic disease
  • treatment

Related Special Issue

Published Papers (3 papers)

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Research

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23 pages, 3427 KiB  
Article
Enhanced Antioxidant and Neuroprotective Properties of Pterostilbene (Resveratrol Derivative) in Amorphous Solid Dispersions
by Natalia Rosiak, Ewa Tykarska and Judyta Cielecka-Piontek
Int. J. Mol. Sci. 2024, 25(5), 2774; https://doi.org/10.3390/ijms25052774 - 28 Feb 2024
Cited by 2 | Viewed by 926
Abstract
In this study, amorphous solid dispersions (ASDs) of pterostilbene (PTR) with polyvinylpyrrolidone polymers (PVP K30 and VA64) were prepared through milling, affirming the amorphous dispersion of PTR via X-ray powder diffraction (XRPD) and differential scanning calorimetry (DSC). Subsequent analysis of DSC thermograms, augmented [...] Read more.
In this study, amorphous solid dispersions (ASDs) of pterostilbene (PTR) with polyvinylpyrrolidone polymers (PVP K30 and VA64) were prepared through milling, affirming the amorphous dispersion of PTR via X-ray powder diffraction (XRPD) and differential scanning calorimetry (DSC). Subsequent analysis of DSC thermograms, augmented using mathematical equations such as the Gordon–Taylor and Couchman–Karasz equations, facilitated the determination of predicted values for glass transition (Tg), PTR’s miscibility with PVP, and the strength of PTR’s interaction with the polymers. Fourier-transform infrared (FTIR) analysis validated interactions maintaining PTR’s amorphous state and identified involved functional groups, namely, the 4′–OH and/or –CH groups of PTR and the C=O group of PVP. The study culminated in evaluating the impact of amorphization on water solubility, the release profile in pH 6.8, and in vitro permeability (PAMPA-GIT and BBB methods). In addition, it was determined how improving water solubility affects the increase in antioxidant (ABTS, DPPH, CUPRAC, and FRAP assays) and neuroprotective (inhibition of cholinesterases: AChE and BChE) properties. The apparent solubility of the pure PTR was ~4.0 µg·mL−1 and showed no activity in the considered assays. For obtained ASDs (PTR-PVP30/PTR-PVPVA64, respectively) improvements in apparent solubility (410.8 and 383.2 µg·mL−1), release profile, permeability, antioxidant properties (ABTS: IC50 = 52.37/52.99 μg·mL−1, DPPH: IC50 = 163.43/173.96 μg·mL−1, CUPRAC: IC0.5 = 122.27/129.59 μg·mL−1, FRAP: IC0.5 = 95.69/98.57 μg·mL−1), and neuroprotective effects (AChE: 39.1%/36.2%, BChE: 76.9%/73.2%) were confirmed. Full article
(This article belongs to the Special Issue Resveratrol: Improving Human Health and Preventing Diseases)
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Review

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20 pages, 2129 KiB  
Review
Resveratrol as a Promising Nutraceutical: Implications in Gut Microbiota Modulation, Inflammatory Disorders, and Colorectal Cancer
by Vidhya Prakash, Chinchu Bose, Damu Sunilkumar, Robin Mathew Cherian, Shwetha Susan Thomas and Bipin G. Nair
Int. J. Mol. Sci. 2024, 25(6), 3370; https://doi.org/10.3390/ijms25063370 - 16 Mar 2024
Cited by 1 | Viewed by 1531
Abstract
Natural products have been a long-standing source for exploring health-beneficial components from time immemorial. Modern science has had a renewed interest in natural-products-based drug discovery. The quest for new potential secondary metabolites or exploring enhanced activities for existing molecules remains a pertinent topic [...] Read more.
Natural products have been a long-standing source for exploring health-beneficial components from time immemorial. Modern science has had a renewed interest in natural-products-based drug discovery. The quest for new potential secondary metabolites or exploring enhanced activities for existing molecules remains a pertinent topic for research. Resveratrol belongs to the stilbenoid polyphenols group that encompasses two phenol rings linked by ethylene bonds. Several plant species and foods, including grape skin and seeds, are the primary source of this compound. Resveratrol is known to possess potent anti-inflammatory, antiproliferative, and immunoregulatory properties. Among the notable bioactivities associated with resveratrol, its pivotal role in safeguarding the intestinal barrier is highlighted for its capacity to prevent intestinal inflammation and regulate the gut microbiome. A better understanding of how oxidative stress can be controlled using resveratrol and its capability to protect the intestinal barrier from a gut microbiome perspective can shed more light on associated physiological conditions. Additionally, resveratrol exhibits antitumor activity, proving its potential for cancer treatment and prevention. Moreover, cardioprotective, vasorelaxant, phytoestrogenic, and neuroprotective benefits have also been reported. The pharmaceutical industry continues to encounter difficulties administering resveratrol owing to its inadequate bioavailability and poor solubility, which must be addressed simultaneously. This report summarizes the currently available literature unveiling the pharmacological effects of resveratrol. Full article
(This article belongs to the Special Issue Resveratrol: Improving Human Health and Preventing Diseases)
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16 pages, 1242 KiB  
Review
Resveratrol and Gut Microbiota Synergy: Preventive and Therapeutic Effects
by Milos Gostimirovic, Jovana Rajkovic, Ana Bukarica, Jovana Simanovic and Ljiljana Gojkovic-Bukarica
Int. J. Mol. Sci. 2023, 24(24), 17573; https://doi.org/10.3390/ijms242417573 - 17 Dec 2023
Cited by 1 | Viewed by 1812
Abstract
The role of an imbalanced high-fat diet in the pathophysiology of common chronic noncommunicable diseases has been known for years. More recently, the concept of ‘gut microbiota’ and the interaction between their composition and gut metabolites produced from the intake of dietary products [...] Read more.
The role of an imbalanced high-fat diet in the pathophysiology of common chronic noncommunicable diseases has been known for years. More recently, the concept of ‘gut microbiota’ and the interaction between their composition and gut metabolites produced from the intake of dietary products have gained the focus of researchers, mostly from the perspective of the prevention of cardiovascular and metabolic disorders, which are still the leading cause of death globally. The aim of this work is to highlight the health benefits of the interaction between resveratrol (RSV), red grape polyphenol, and gut microbiota, through aspects of their therapeutic and preventive potentials. Since changed microbiota (mostly as a consequence of antibiotic overuse) contribute to the persistence of post (‘long’)-COVID-19 symptoms, these aspects will be covered too. Data were obtained from the electronic databases (MedLine/PubMed), according to specific keywords regarding the protective role of resveratrol, the gut microbiota, and their synergy. RSV exerts beneficial properties in the modulation of cardiovascular, metabolic, and post-COVID-19-related disorders. In healthy individuals, it maintains an ergogenic capacity, prevents oxidative stress, and modulates the inflammatory response. Overall, it improves quality of life. The RSV–gut-microbiota interaction is beneficial in terms of maintaining human health. Along with physical activity, it is key for the prevention of chronic noncommunicable diseases. Full article
(This article belongs to the Special Issue Resveratrol: Improving Human Health and Preventing Diseases)
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