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Natural Products as Anti-cancer Agents Compared to Synthetic Conventional Chemotherapy

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: closed (30 September 2021) | Viewed by 2710

Special Issue Editor

Special Issue Information

Dear Colleagues,

Natural products can be isolated from several biological sources, such as plants, fungi, animals and plant cell cultures, among others. Currently, results from many studies have supported the feasibility of herbal medicine and nature food as potent chemopreventive drugs, such as being used as antitumoral and antiangiogenic agents. It has been shown that treatment using natural products with antitumoral and antiangiogenic properties is less toxic to human cells, especially compared to the conventional clinical chemotherapy and radiotherapy. However, there is still a lack of more scientific evidence to support their approbation. Thus, there is a need for more scientific evidence to explore these treatments as they can directly target specific cancers, as well as having potential for improved therapeutic efficacies with reduced toxicities. This Research Topic aims to highlight research on natural products, specifically compounds including terpenes, flavonoids, alkaloids and phytoestrogen, and their cancer-preventive characteristics. This Issue also aims to detail the composition, stability, antiangiogenic potential and/or antitumoral action of biomolecules. Research may include natural products derived from biological sources with some chemical modifications. Antitumoral modalities of natural products can be demonstrated using in vivo models. This must be supported in at least two well-authenticated cancer cell lines.

Dr. Ming-Ju Hsieh
Guest Editor

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Keywords

  • natural products
  • antitumoral
  • new drugs
  • mechanisms of action

Published Papers (1 paper)

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Research

13 pages, 4894 KiB  
Article
PlatyphyllenoneExerts Anti-Metastatic Effects on Human Oral Cancer Cells by Modulating Cathepsin L Expression, MAPK Pathway and Epithelial–Mesenchymal Transition
by V. Bharath Kumar, Jen-Tsun Lin, B. Mahalakshmi, Yi-Ching Chuang, Hsin-Yu Ho, Chia-Chieh Lin, Yu-Sheng Lo, Ming-Ju Hsieh and Mu-Kuan Chen
Int. J. Mol. Sci. 2021, 22(9), 5012; https://doi.org/10.3390/ijms22095012 - 9 May 2021
Cited by 4 | Viewed by 2152
Abstract
Advanced-stage oral cancers with lymph node metastasis are associated with poor prognosis and a high mortality rate. Although recent advancement in cancer treatment has effectively improved the oral cancer prognosis, the majority of therapeutic interventions are highly expensive and are associated with severe [...] Read more.
Advanced-stage oral cancers with lymph node metastasis are associated with poor prognosis and a high mortality rate. Although recent advancement in cancer treatment has effectively improved the oral cancer prognosis, the majority of therapeutic interventions are highly expensive and are associated with severe sideeffects. In the present study, we studied the efficacy of a diarylheptanoid derivative, platyphyllenone, in modulating the metastatic potential of human oral cancer cells. Specifically, we treated the human oral cancer cells (FaDu, Ca9-22, and HSC3) with different concentrations of platyphyllenone and measured the cell proliferation, migration, and invasion. The study findings revealed that platyphyllenonesignificantly inhibited the motility, migration, and invasion of human oral cancer cells. Mechanistically, platyphyllenone reduced p38 phosphorylation, decreased β-catenin and Slug, increased E-cadherin expression, and reduced cathepsin L expression, which collectively led to a reduction in cancer cell migration and invasion. Taken together, our study indicates that platyphyllenone exerts significant anti-metastatic effects on oral cancer cells by modulating cathepsin L expression, the MAPK signaling pathway, and the epithelial–mesenchymal transition process. Full article
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