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Recent Advances in Biosurfactants

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Materials Science".

Deadline for manuscript submissions: closed (20 April 2024) | Viewed by 5485

Special Issue Editors


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Guest Editor
1. CEB—Centre of Biological Engineering, University of Minho, 4710-057 Braga, Portugal
2. LABBELS-Associate Laboratory, 4710-057 Braga, Portugal
Interests: biosurfactants; bioactive molecules; adhesion and biofilms; synthetic biology; industrial biotechnology; bioprocess development; functional food and biomarkers
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
1. CEB—Centre of Biological Engineering, University of Minho, 4710-057 Braga, Portugal
2. LABBELS-Associate Laboratory, 4710-057 Braga, Portugal
Interests: biosurfactants; synthetic biology; industrial biotechnology; bioprocess development; biomarkers
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
1. CEB—Centre of Biological Engineering, University of Minho, 4710-057 Braga, Portugal
2. LABBELS - Associate Laboratory, Braga/Guimaraes, Portugal
Interests: cancer; fungal infections; metagenomics; lactoferrin; biosurfactants and enzymes; bioprocess development
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Biosurfactants comprise a group of diverse and versatile amphipathic molecules with distinct chemical structures and produced by numerous microorganisms. These molecules, which are mainly formed as secondary metabolites, play critical roles in the survival of the producing microorganisms by facilitating nutrient transport, interfering in microbe–host interactions and quorum sensing mechanisms, or by acting as biocide agents. Their recognized potential and biological nature have inspired numerous studies on their possible applications over the last decades. It is claimed that these compounds are superior to their chemical counterparts owing to their microbial origin, biodegradability, and low toxicity. For this reason, these fascinating compounds have been widely studied for applications in the medical, biomedical, food and cosmetics industries as well as in enhanced oil recovery and bioremediation, among others.

Despite their unique features and potential, the applications of biosurfactants significantly depend on whether they can be produced economically, which indeed constitutes the main limitation to their wide adoption by industry. Hence, the current focus on sustainability and circular economy are driving great efforts in bioprocess optimization and at the engineering and biological levels.

This Special Issue of International Journal of Molecular Sciences, entitled “Recent Advances in Biosurfactants”, welcomes the submission of original articles or reviews that can highlight and improve knowledge on the potential applications of biosurfactants in several industries, analyzing the main limitations and constraints of the bioprocesses; on the biosurfactants biosynthesis, roles, properties, and activities, also focusing on new producers; on the biosurfactant production, recovery, and characterization, with focus on novel methodologies; and on the biosurfactants market, process economics, and strategies to improve process sustainability and contribute to a circular economy.

Dr. Lígia R. Rodrigues
Dr. Débora Ferreira
Dr. Cátia Pereira
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

 

Keywords

  • tensioactive molecules
  • surface adhesion
  • antimicrobial activity
  • antibiofilm activity
  • emulsions
  • drug delivery

Published Papers (3 papers)

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Research

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19 pages, 2608 KiB  
Article
Rhamnolipid 89 Biosurfactant Is Effective against Streptococcus oralis Biofilm and Preserves Osteoblast Behavior: Perspectives in Dental Implantology
by Erica Tambone, Chiara Ceresa, Alice Marchetti, Silvia Chiera, Adriano Anesi, Giandomenico Nollo, Iole Caola, Michela Bosetti, Letizia Fracchia, Paolo Ghensi and Francesco Tessarolo
Int. J. Mol. Sci. 2023, 24(18), 14014; https://doi.org/10.3390/ijms241814014 - 13 Sep 2023
Viewed by 791
Abstract
Biofilm-related peri-implant diseases represent the major complication for osteointegrated dental implants, requiring complex treatments or implant removal. Microbial biosurfactants emerged as new antibiofilm coating agents for implantable devices thanks to their high biocompatibility. This study aimed to assess the efficacy of the rhamnolipid [...] Read more.
Biofilm-related peri-implant diseases represent the major complication for osteointegrated dental implants, requiring complex treatments or implant removal. Microbial biosurfactants emerged as new antibiofilm coating agents for implantable devices thanks to their high biocompatibility. This study aimed to assess the efficacy of the rhamnolipid 89 biosurfactant (R89BS) in limiting Streptococcus oralis biofilm formation and dislodging sessile cells from medical grade titanium, but preserving adhesion and proliferation of human osteoblasts. The inhibitory activity of a R89BS coating on S. oralis biofilm formation was assayed by quantifying biofilm biomass and microbial cells on titanium discs incubated up to 72 h. R89BS dispersal activity was addressed by measuring residual biomass of pre-formed biofilms after rhamnolipid treatment up to 24 h. Adhesion and proliferation of human primary osteoblasts on R89BS-coated titanium were evaluated by cell count and adenosine-triphosphate quantification, while cell differentiation was studied by measuring alkaline phosphatase activity and observing mineral deposition. Results showed that R89BS coating inhibited S. oralis biofilm formation by 80% at 72 h and dislodged 63–86% of pre-formed biofilms in 24 h according to concentration. No change in the adhesion of human osteoblasts was observed, whereas proliferation was reduced accompanied by an increase in cell differentiation. R89BS effectively counteracts S. oralis biofilm formation on titanium and preserves overall osteoblasts behavior representing a promising preventive strategy against biofilm-related peri-implant diseases. Full article
(This article belongs to the Special Issue Recent Advances in Biosurfactants)
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Review

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27 pages, 1561 KiB  
Review
Latest Trends in Lipase-Catalyzed Synthesis of Ester Carbohydrate Surfactants: From Key Parameters to Opportunities and Future Development
by Alexis Spalletta, Nicolas Joly and Patrick Martin
Int. J. Mol. Sci. 2024, 25(7), 3727; https://doi.org/10.3390/ijms25073727 - 27 Mar 2024
Viewed by 561
Abstract
Carbohydrate-based surfactants are amphiphilic compounds containing hydrophilic moieties linked to hydrophobic aglycones. More specifically, carbohydrate esters are biosourced and biocompatible surfactants derived from inexpensive renewable raw materials (sugars and fatty acids). Their unique properties allow them to be used in various areas, such [...] Read more.
Carbohydrate-based surfactants are amphiphilic compounds containing hydrophilic moieties linked to hydrophobic aglycones. More specifically, carbohydrate esters are biosourced and biocompatible surfactants derived from inexpensive renewable raw materials (sugars and fatty acids). Their unique properties allow them to be used in various areas, such as the cosmetic, food, and medicine industries. These multi-applications have created a worldwide market for biobased surfactants and consequently expectations for their production. Biobased surfactants can be obtained from various processes, such as chemical synthesis or microorganism culture and surfactant purification. In accordance with the need for more sustainable and greener processes, the synthesis of these molecules by enzymatic pathways is an opportunity. This work presents a state-of-the-art lipase action mode, with a focus on the active sites of these proteins, and then on four essential parameters for optimizing the reaction: type of lipase, reaction medium, temperature, and ratio of substrates. Finally, this review discusses the latest trends and recent developments, showing the unlimited potential for optimization of such enzymatic syntheses. Full article
(This article belongs to the Special Issue Recent Advances in Biosurfactants)
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25 pages, 1788 KiB  
Review
An Overview on the Treatment of Oil Pollutants in Soil Using Synthetic and Biological Surfactant Foam and Nanoparticles
by Kien A. Vu and Catherine N. Mulligan
Int. J. Mol. Sci. 2023, 24(3), 1916; https://doi.org/10.3390/ijms24031916 - 18 Jan 2023
Cited by 6 | Viewed by 3443
Abstract
Oil-contaminated soil is one of the most concerning problems due to its potential damage to human, animals, and the environment. Nanoparticles have effectively been used to degrade oil pollution in soil in the lab and in the field for a long time. In [...] Read more.
Oil-contaminated soil is one of the most concerning problems due to its potential damage to human, animals, and the environment. Nanoparticles have effectively been used to degrade oil pollution in soil in the lab and in the field for a long time. In recent years, surfactant foam and nanoparticles have shown high removal of oil pollutants from contaminated soil. This review provides an overview on the remediation of oil pollutants in soil using nanoparticles, surfactant foams, and nanoparticle-stabilized surfactant foams. In particular, the fate and transport of oil compounds in the soil, the interaction of nanoparticles and surfactant foam, the removal mechanisms of nanoparticles and various surfactant foams, the effect of some factors (e.g., soil characteristics and amount, nanoparticle properties, surfactant concentration) on remediation efficiency, and some advantages and disadvantages of these methods are evaluated. Different nanoparticles and surfactant foam can be effectively utilized for treating oil compounds in contaminated soil. The treatment efficiency is dependent on many factors. Thus, optimizing these factors in each scenario is required to achieve a high remediation rate while not causing negative effects on humans, animals, and the environment. In the future, more research on the soil types, operating cost, posttreatment process, and recycling and reuse of surfactants and nanoparticles need to be conducted. Full article
(This article belongs to the Special Issue Recent Advances in Biosurfactants)
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