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Molecular Mechanisms and Therapies of Brain Cancers

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".

Deadline for manuscript submissions: closed (15 March 2024) | Viewed by 2178

Special Issue Editor


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Guest Editor
Department of Oncology and Hemato-Oncology, University of Milan, 20122 Milan, Italy
Interests: neurooncology; brain mapping; intraoperative neuromonitoring; skull base tumours

Special Issue Information

Dear Colleagues,

Brain tumours represent a limited but complex proportion of the oncological landscape in adults and a unpleasant relevant group in paediatric population. Brain tumours research field has become more complex than ever in the last decades, as involvement of several healthcare specialists and scientific experts is mandatory to develop a new standard of care for some largely unknown and incurable diseases and to optimise treatments for more indolent diseases. The inter-relation of tumour biology heterogeneity, peritumoural interface with the immune system, tumour-driven escape mechanisms and resistance to current treatments are the challenges for future research.

This Special Issue is focused on the collection of papers regarding “Recent Advances in Brain Cancers” and calls to actions biologists, neurosurgeons, oncologists, radiation oncologists and immunologists to share recent advances in neurooncology, discuss and propose new insights and perspectives for possible promising directions to follow. The aim of the Issue is to collect valuable contribution from basic sciences, translational research on signalling pathways highly relevant in term of future target therapy delivery, new technologies and their impact on tumour biology but also critical review of recent and forthcoming clinical trials investigating new molecules or treatment strategies. Both adult and paediatric neurooncology topics are welcome.

Dr. Leonardo Tariciotti
Guest Editor

Manuscript Submission Information

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Keywords

  • neurooncology
  • gliomas
  • signaling pathways
  • target therapies
  • immunotherapies
  • extra-axial brain tumours
  • clinical trials

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Published Papers (1 paper)

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Review

19 pages, 1252 KiB  
Review
Gliomagenesis, Epileptogenesis, and Remodeling of Neural Circuits: Relevance for Novel Treatment Strategies in Low- and High-Grade Gliomas
by Alessandro Grimi, Beatrice C. Bono, Serena M. Lazzarin, Simona Marcheselli, Federico Pessina and Marco Riva
Int. J. Mol. Sci. 2024, 25(16), 8953; https://doi.org/10.3390/ijms25168953 - 16 Aug 2024
Cited by 3 | Viewed by 1657
Abstract
Gliomas present a complex challenge in neuro-oncology, often accompanied by the debilitating complication of epilepsy. Understanding the biological interaction and common pathways between gliomagenesis and epileptogenesis is crucial for improving the current understanding of tumorigenesis and also for developing effective management strategies. Shared [...] Read more.
Gliomas present a complex challenge in neuro-oncology, often accompanied by the debilitating complication of epilepsy. Understanding the biological interaction and common pathways between gliomagenesis and epileptogenesis is crucial for improving the current understanding of tumorigenesis and also for developing effective management strategies. Shared genetic and molecular mechanisms, such as IDH mutations and dysregulated glutamate signaling, contribute to both tumor progression and seizure development. Targeting these pathways, such as through direct inhibition of mutant IDH enzymes or modulation of glutamate receptors, holds promise for improving patient outcomes. Additionally, advancements in surgical techniques, like supratotal resection guided by connectomics, offer opportunities for maximally safe tumor resection and enhanced seizure control. Advanced imaging modalities further aid in identifying epileptogenic foci and tailoring treatment approaches based on the tumor’s metabolic characteristics. This review aims to explore the complex interplay between gliomagenesis, epileptogenesis, and neural circuit remodeling, offering insights into shared molecular pathways and innovative treatment strategies to improve outcomes for patients with gliomas and associated epilepsy. Full article
(This article belongs to the Special Issue Molecular Mechanisms and Therapies of Brain Cancers)
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