International Journal of Molecular Sciences

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Dear Colleagues,

Ischemia–reperfusion injury (IRI) is inherent to surgery and organ resection and transplantationnterests (TX). The cumulative damage due to ischemia and reperfusion associated with organ transplantation compromises the viability of the organ and its successful transplantation outcome. The present knowledge of underlying IRI pathophysiological mechanisms reveals a complex cell signaling crossroads that make further therapeutic strategies difficult and justify the in-depth investigation of the cell signaling pathways involved in IRI to prevent its adverse consequences more effectively and improve organ transplantation outcomes.

The advances in the study of IRI pathophysiology mechanisms are poor when compared to the development of immunosuppressive strategies in TX. For this reason, and continuing with the core idea of previous Special Issues, it is necessary to explore new insights into the molecular pathways involved in the complex pathophysiology of IRI, covering different perspectives, including different organs (heart, liver, kidney, pancreas, small intestine), with a special emphasis on the underlying mechanisms, including, but not limited to, the involvement of inflammatory mediators, mitochondrial dysfunction, apoptosis, and other potential markers associated with IRI.

This Special Issue calls for original research, full reviews, and perspectives that address the progress and current knowledge on the pathophysiological mechanisms of IRI in different organs. This includes protective graft preservation strategies with MP, surgical intervention, ischemic preconditioning/postconditioning, and pharmacological strategies including clinical and experimental settings. We welcome studies on the pathophysiological mechanisms involved in warm and cold ischemia and inherent reperfusion and any strategy aimed at the prevention of IRI. Contributions are not limited to the fields that are mentioned in the keywords.

Due to the success of the first volume of this Special Issue, we would like to continue the push to advance this field and are therefore looking to publish more results and new insights from recent research projects. You can find the first volume at the following link:

https://www.mdpi.com/journal/ijms/special_issues/YMS09AXMPR.

Prof. Dr. Joan Roselló-Catafau
Prof. Dr. René Adam
Dr. Arnau Panisello-Roselló
Guest Editors

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Related Special Issue

Published Papers (1 paper)

Review

25 pages, 888 KiB

Open AccessReview

Steatotic Donor Transplant Livers: Preservation Strategies to Mitigate against Ischaemia-Reperfusion Injury

by Syed Hussain Abbas, Carlo Domenico Lorenzo Ceresa and Joerg-Matthias Pollok

Int. J. Mol. Sci. 2024, 25(9), 4648; https://doi.org/10.3390/ijms25094648 - 24 Apr 2024

Viewed by 275

Abstract

Liver transplantation (LT) is the only definitive treatment for end-stage liver disease, yet the UK has seen a 400% increase in liver disease-related deaths since 1970, constrained further by a critical shortage of donor organs. This shortfall has necessitated the use of extended criteria donor organs, including those with evidence of steatosis. The impact of hepatic steatosis (HS) on graft viability remains a concern, particularly for donor livers with moderate to severe steatosis which are highly sensitive to the process of ischaemia-reperfusion injury (IRI) and static cold storage (SCS) leading to poor post-transplantation outcomes. This review explores the pathophysiological predisposition of steatotic livers to IRI, the limitations of SCS, and alternative preservation strategies, including novel organ preservation solutions (OPS) and normothermic machine perfusion (NMP), to mitigate IRI and improve outcomes for steatotic donor livers. By addressing these challenges, the liver transplant community can enhance the utilisation of steatotic donor livers which is crucial in the context of the global obesity crisis and the growing need to expand the donor pool. Full article

(This article belongs to the Special Issue Ischemia Reperfusion Injury: A Cell Signaling Crossroads and Therapeutics 2.0)

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