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Novel Extracellular and Intracellular Signalling Mechanisms in Bone 3.0

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: closed (31 March 2023) | Viewed by 1991

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Special Issue Information

Dear Colleagues,

Bone is influenced by environmental and genetic factors and numerous local and systemic regulators. Molecular and cellular studies have identified mechanisms in various stem cells and specialized bone cells that affect bone development, bone maintenance, and bone regeneration. Impaired bone metabolisms induce exaggerated bone loss in patients with diseases characterized by decreased bone mass and increased risk of fractures. This Special Issue focuses on novel extracellular and intracellular signaling mechanisms contributing to bone morphogenesis, bone formation, bone remodeling, and bone diseases. We warmly welcome submissions, including original papers and reviews, on this widely discussed topic.

Prof. Dr. Hyung-Mun Yun
Dr. Kyung-Ran Park
Guest Editors

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Keywords

  • bone formation
  • bone remodeling
  • bone disease
  • osteoclast

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Published Papers (1 paper)

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Research

12 pages, 2603 KiB  
Article
Suffruticosol B Is an Osteogenic Inducer through Osteoblast Differentiation, Autophagy, Adhesion, and Migration
by Hyung-Mun Yun, Joon Yeop Lee, Bomi Kim and Kyung-Ran Park
Int. J. Mol. Sci. 2022, 23(21), 13559; https://doi.org/10.3390/ijms232113559 - 4 Nov 2022
Viewed by 1583
Abstract
Suffruticosol B (Suf-B) is a stilbene found in Paeonia suffruticosa ANDR., which has been traditionally used in medicine. Stilbenes and their derivatives possess various pharmacological effects, such as anticancer, anti-inflammatory, and anti-osteoporotic activities. This study aimed to explore the bone-forming activities and mechanisms [...] Read more.
Suffruticosol B (Suf-B) is a stilbene found in Paeonia suffruticosa ANDR., which has been traditionally used in medicine. Stilbenes and their derivatives possess various pharmacological effects, such as anticancer, anti-inflammatory, and anti-osteoporotic activities. This study aimed to explore the bone-forming activities and mechanisms of Suf-B in pre-osteoblasts. Herein, >99.9% pure Suf-B was isolated from P. suffruticosa methanolic extracts. High concentrations of Suf-B were cytotoxic, whereas low concentrations did not affect cytotoxicity in pre-osteoblasts. Under zero levels of cytotoxicity, Suf-B exhibited bone-forming abilities by enhancing alkaline phosphatase enzyme activities, bone matrix calcification, and expression levels with non-collagenous proteins. Suf-B induces intracellular signal transduction, leading to nuclear RUNX2 expression. Suf-B-stimulated differentiation showed increases in autophagy proteins and autophagosomes, as well as enhancement of osteoblast adhesion and transmigration on the ECM. These results indicate that Suf-B has osteogenic qualities related to differentiation, autophagy, adhesion, and migration. This also suggests that Suf-B could have a therapeutic effect as a phytomedicine in skeletal disorders. Full article
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