Fishes

Special Issue Editor

Dr. Jin Xu

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Guest Editor

Yangtze River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Wuhan 430223, China
Interests: aquaculture animal diseases; etiology; pathogenic mechanism; antibiotic; vaccine; prevention; treatment

Special Issue Information

Dear Colleagues,

Disease is the bottleneck of the healthy and sustainable development of the aquaculture industry. It not only directly causes huge economic losses, but also causes problems of bacterial resistance, drug residues in aquatic products, and ecological pollution, which further limits the sustainable development of the industry. Research on the etiology of emerging diseases, the pathogenic mechanism of pathogens, host immune mechanisms, and new prevention and control technologies, such as green antibacterial drugs, new technology vaccines, the development of high-efficiency microecological preparations, or antagonistic bacteria, are extremely important for healthy aquaculture. In view of this, original research manuscripts on the “Prevention and Treatment of Aquaculture Animal Diseases” are welcome:

Etiology of emerging diseases;
Interaction between aquaculture pathogens and their hosts;
Efficient vaccine development and its effect evaluation;
Development and safety evaluation of antibiotic substitutes (probiotics, Chinese herbs, etc.) with potential use in the control of aquaculture pathogens;
New technologies for prevention and control of aquaculture animal diseases.

Dr. Jin Xu
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Fishes is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

aquaculture animal diseases
etiology
pathogenic mechanism
antibiotic
vaccine
prevention
treatment

Published Papers (2 papers)

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Research

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20 pages, 6009 KiB

Open AccessArticle

The Mechanism of Elizabethkingia miricola Infection of the Black Spotted Frog as Revealed by Multi-Omics Analysis

by Qingcong Wei, Dan Wang, Kaijin Wei, Bin Xu and Jin Xu

Fishes 2024, 9(3), 91; https://doi.org/10.3390/fishes9030091 - 28 Feb 2024

Viewed by 1071

Abstract

Elizabethkingia miricola (E. miricola) is a significant pathogen that causes the crooked head disease in black spotted frogs. This disease has plagued numerous frog farms in China and has resulted in substantial losses to the frog farming industry. Nonetheless, the exact mechanism that causes the disease in frogs remains unknown. In this study, transcriptomic and microbiomic analyses were conducted to analyze frog samples infected with E. miricola to reveal the infection mechanism of the pathogen. Liver transcriptomic analysis indicated that the livers of infected frogs had 1469 differentially expressed genes when compared with an uninfected group. These DEGs are mainly involved in immunity and metabolism, including neutrophil extracellular trap formation, the NOD-like receptor signaling pathway, leukocyte transendothelial migration, chemokine signaling pathway, Fc gamma R-mediated phagocytosis, and “metabolism”-related pathways such as the pentose phosphate pathway, carbon metabolism, glycerophospholipid metabolism, and glycerolipid metabolism. Similarly, 4737 DEGs were found in the kidney of infected frogs. These DEGs are mainly involved in immunity, including neutrophil extracellular trap formation, the NOD-like receptor signaling pathway, B cell receptor signaling pathway, C-type lectin receptor signaling pathway, complement and coagulation cascade, and Toll-like receptor signaling pathway. Ten immune-associated DEGs were screened in liver and kidney DEGs, respectively. And it was hypothesized that E. miricola infection could influence the host immune response. Microbiome analysis results showed that some opportunistic pathogens such as Citrobacter, Shigella, and Providencia were significantly elevated (p < 0.05) in infected frogs. Additionally, functional prediction confirmed that most of the microbiota in infected frogs were linked to metabolism-related KEGG pathways. In this study, the screened genes linked to immunity showed an association with the gut microbiome. The majority of these genes were found to be linked with the abundance of opportunistic pathogens. The results showed that E. miricola infection led to the downregulation of immune and metabolic-related genes, which led to the inhibition of immune function and metabolic disorder, and then increased the abundance of opportunistic pathogens in the gut microbiota. The findings of this study offer a preliminary foundation for comprehending the pathogenic processes of E. miricola infection in black spotted frogs. Full article

(This article belongs to the Special Issue Prevention and Treatment of Aquaculture Animal Diseases)

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Review

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19 pages, 3139 KiB

Open AccessReview

Applications of Antimicrobial Photodynamic Therapy in Aquaculture: Effect on Fish Pathogenic Bacteria

by Edith Dube and Grace Emily Okuthe

Fishes 2024, 9(3), 99; https://doi.org/10.3390/fishes9030099 - 5 Mar 2024

Viewed by 1247

Abstract

Increased infectious diseases and the reduced effectiveness of antibiotics due to antimicrobial resistance pose global challenges affecting the aquaculture industry. As bacteria increasingly develop antibiotic resistance, research scientists are shifting their focus to technologies such as antimicrobial photodynamic therapy (aPDT), which show potential for treating and controlling fish infections without promoting the development of resistant bacteria. Various photosensitizers (PSs), both natural and synthetic, are under investigation for their application in aPDT within the aquaculture industry. This shift is crucial for the sustainability of the aquaculture industry, which plays a significant role in achieving several of the United Nations (UN) Sustainable Development Goals (SDGs). This review highlights the application of aPDT against fish pathogens in the industry and the types of PSs utilized. It also explores the potential application of this technique for treating and controlling fish infections, along with the advantages and limitations of its use in aquaculture production systems. Finally, a conclusion and future perspectives are provided. Full article

(This article belongs to the Special Issue Prevention and Treatment of Aquaculture Animal Diseases)

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