Enzyme-Based Biosensors and Applications
A special issue of Fermentation (ISSN 2311-5637). This special issue belongs to the section "Microbial Metabolism, Physiology & Genetics".
Deadline for manuscript submissions: closed (31 October 2017) | Viewed by 198
Special Issue Editor
Interests: recombinant enzyme production; maturation of enzyme complexes; metabolic engineering; hydogen-based biotechnology
Special Issue Information
Dear Colleagues,
The monitoring of biotechnological processes using suitable online analytical methods still represents a technological challenge nowadays. The potential of these developments, however, is nowhere more apparent than in the DNA sequencing, where units of mobile phone size at a price of less than €1,000 can be used today. By combining advanced microchips with intelligent microelectronics and microfluidics, and the unique selectivity of enzymes, multiple parameters of fermentation processes are accessible at the same time by “lab-on-a-chip”-technologies. The direct and simultaneous measurement of various substrate and product concentrations allows to respond to process changes or product quality variations immediately. The description of fermentation courses with until now unmatched temporal resolution provides contemporary information about the state of the process and permits responses to faults. This facilitates customizing ongoing fermentations for optimum results. Scientific and technological challenges in the development of enzyme-based biosensors are essentially defined by the required specificity and stability of the enzymes, compatible enzyme test designs, enzyme immobilization on surfaces, the development of suitable sensor chips with integrated microfluidics and the validation of the biosensors in real life. Decisions as to which of these components are to prioritize during the stages of sensor development further influences the overall management of such endeavors, and directly affects early implementation of novel analytical techniques in the industry. The Special Issue will focus on recent developments of enzyme-based biosensors for bioprocess monitoring in fermentations that reflect one or more of these themes.
Prof. Dr. Thorsten Selmer
Guest Editor
Manuscript Submission Information
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Keywords
- biosensors
- enzymes
- microfluidics
- enzyme immobilization
- multi-parameter sensor chips
- online monitoring
- fermentation
- process optimization
- metabolism
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