Special Issue "Pathogenesis of Pancreatic Cancer"

A special issue of Diseases (ISSN 2079-9721). This special issue belongs to the section "Oncology".

Deadline for manuscript submissions: 30 November 2018

Special Issue Editor

Guest Editor
Prof. Dr. Marco Falasca

School of Biomedical Sciences, Faculty of Health Sciences, Curtin University, Perth, WA, Australia
Website | E-Mail
Interests: signal transduction, cancer invasion and metastasis in prostate, breast and pancreatic cancers; phosphoinositide signalling; PI3-kinase/PDK1 signalling pathway

Special Issue Information

Dear Colleagues,

Pancreatic ductal adenocarcinoma (PDAC) is still one of the most aggressive and lethal malignancy in Western countries, with a low survival rate of around 5% that has remained unchanged for the last 40 years. The reason for this standstill resides in both the difficulty in diagnosing the disease at an early stage, due to non-specificity or lack of symptoms, and the inefficacy of the treatments currently available, caused by resistance to chemotherapy and radiotherapy. PDAC cells are characterised by a tendency to infiltrate into the endothelium basement membrane and neurons and to propagate speedily to distant organs through the lymphatic system, causing metastasis. At molecular level, it is known that the activation of oncogenes, such as KRAS and NOTCH, and the blocking of tumour suppressor genes like p16, p53, SMAD4 and PTEN, are involved in the initiation and advancement of this disease. In addition, various cell signalling pathways, such EGFR, Akt and NF-kB, have been found to be disrupted, contributing to PDAC evolution. Despite all these advances in the understanding of the molecular pathogenesis of PDAC, further insight in the knowledge of this disease and new efficacious therapeutic strategies are urgently required in order to improve the outcomes for PDAC patients.

Prof. Dr. Marco Falasca
Guest Editor

Manuscript Submission Information

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Keywords

  • pancreatic cancer
  • pancreatic ductal adenocarcinoma
  • molecular pathogenesis
  • chemotherapy
  • metastasis
  • cancer biology

Published Papers (1 paper)

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Review

Open AccessReview Pancreatic Cystic Lesions: Pathogenesis and Malignant Potential
Received: 15 May 2018 / Revised: 6 June 2018 / Accepted: 7 June 2018 / Published: 13 June 2018
PDF Full-text (251 KB) | HTML Full-text | XML Full-text | Supplementary Files
Abstract
Pancreatic cancer remains one of the most lethal cancers despite extensive research. Further understanding of precursor lesions may enhance the ability to treat and prevent pancreatic cancer. Pancreatic cystic lesions (PCLs) with malignant potential include: mucinous PCLs (intraductal papillary mucinous neoplasms and mucinous
[...] Read more.
Pancreatic cancer remains one of the most lethal cancers despite extensive research. Further understanding of precursor lesions may enhance the ability to treat and prevent pancreatic cancer. Pancreatic cystic lesions (PCLs) with malignant potential include: mucinous PCLs (intraductal papillary mucinous neoplasms and mucinous cystic neoplasm), solid pseudopapillary tumors and cystic neuroendocrine tumors. This review summarizes the latest literature describing what is known about the pathogenesis and malignant potential of these PCLs, including unique epidemiological, radiological, histological, genetic and molecular characteristics. Full article
(This article belongs to the Special Issue Pathogenesis of Pancreatic Cancer)

Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Title: The pathogenesis of pancreatic cystic lesions and progression to pancreatic ductal adenocarcinoma
Article type: Review
Authors: Antoinette J. Pusateri and Somashekar Krishna (USA)

Tentative title: Pathogenesis of Pancreatic Cancer
Article type: Review
Author: Marina Pajic (Australia)

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