Special Issue "Pathogenesis of Pancreatic Cancer"

A special issue of Diseases (ISSN 2079-9721). This special issue belongs to the section "Oncology".

Deadline for manuscript submissions: 31 May 2018

Special Issue Editor

Guest Editor
Prof. Dr. Marco Falasca

School of Biomedical Sciences, Faculty of Health Sciences, Curtin University, Perth, WA, Australia
Website | E-Mail
Interests: signal transduction, cancer invasion and metastasis in prostate, breast and pancreatic cancers; phosphoinositide signalling; PI3-kinase/PDK1 signalling pathway

Special Issue Information

Dear Colleagues,

Pancreatic ductal adenocarcinoma (PDAC) is still one of the most aggressive and lethal malignancy in Western countries, with a low survival rate of around 5% that has remained unchanged for the last 40 years. The reason for this standstill resides in both the difficulty in diagnosing the disease at an early stage, due to non-specificity or lack of symptoms, and the inefficacy of the treatments currently available, caused by resistance to chemotherapy and radiotherapy. PDAC cells are characterised by a tendency to infiltrate into the endothelium basement membrane and neurons and to propagate speedily to distant organs through the lymphatic system, causing metastasis. At molecular level, it is known that the activation of oncogenes, such as KRAS and NOTCH, and the blocking of tumour suppressor genes like p16, p53, SMAD4 and PTEN, are involved in the initiation and advancement of this disease. In addition, various cell signalling pathways, such EGFR, Akt and NF-kB, have been found to be disrupted, contributing to PDAC evolution. Despite all these advances in the understanding of the molecular pathogenesis of PDAC, further insight in the knowledge of this disease and new efficacious therapeutic strategies are urgently required in order to improve the outcomes for PDAC patients.

Prof. Dr. Marco Falasca
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diseases is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 350 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • pancreatic cancer
  • pancreatic ductal adenocarcinoma
  • molecular pathogenesis
  • chemotherapy
  • metastasis
  • cancer biology

Published Papers

This special issue is now open for submission, see below for planned papers.

Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Title: The pathogenesis of pancreatic cystic lesions and progression to pancreatic ductal adenocarcinoma
Article type: Review
Authors: Antoinette J. Pusateri and Somashekar Krishna (USA)

Tentative title: Pathogenesis of Pancreatic Cancer
Article type: Review
Author: Marina Pajic (Australia)

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