Special Issue "Cosmetic Formulation Strategy: From Raw Materials to Packaging by Nanotechnology and Nanobiotechnology's Processes"

A special issue of Cosmetics (ISSN 2079-9284).

Deadline for manuscript submissions: 15 October 2018

Special Issue Editor

Guest Editor
Prof. Dr. Pierfrancesco Morganti

Campania University, Department Mental/Physical Health and Preventive Medicine, Naples, Italy
Website | E-Mail
Interests: cosmetic chemists; biologists, material engineers; cosmetic marketers; pharmacists; experts in esthetic medicine, dermatologists, and plastic surgeons

Special Issue Information

Dear Colleagues,

Cosmetic Science is a highly diversified scientific field, where the different ingredients used to formulate a cosmetic product, with their various mechanisms of action, meet the complex biological systems of skin and its appendages and of mucous membranes. Thus, the cosmetic scientist needs not only to know the physicochemical characteristics and functionalities of the chemicals and natural ingredients used to formulate a certain cosmetic, but also to recognize or forecast the possible interactions occurring when these ingredients are emulsified or otherwise combined and blended. Moreover, the cosmetic scientist should have a deep knowledge of the skin and mucous membranes, as the formulated products are finally applied on these biological structures with the aim of "cleaning, perfuming, and changing their appearance to keep them in good conditions", according to the EU rules. All the selected ingredients need to be effective and skin-safe. For this purpose, a deep knowledge of the methodologies used to control the effectiveness and safety of both ingredients and final formulation have to be part of the chemist/biochemist learnings. Finally, the cosmetic formulator should be acquainted with the raw materials used to produce the primary and secondary packaging, in order to avoid the release of toxic compounds from the container into the content. Last but not least, it is necessary that both the primary and secondary packaging materials should be biodegradable and environmentally friendly. All this extended culture should be combined with a deep involvement in R&D investigation.

The cosmetic market growth is characterized by constantly innovative products and tools, as continuously requested by customers and consumers. For this reason, nanotechnology- and nanobiotechnology-based ingredients are becoming fundamental components of many cosmetic formulations. Because of the growing request of natural products, nanobiotechnology is the actual emergent field of nanotechnology. This is due to its ability to integrate biotechnology on the nanoscale interfacing with biological and natural systems. This Special cosmetic Issue has the aim to introduce the reader to the fascinating field of nanotechnology and nanobiotechnology in the cosmetic sector, whose application is increasingly necessary to produce innovative products, while trying also to solve the issues and meaning of the so-called natural and bio-cosmetics.

Prof. Dr. Pierfrancesco Morganti
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cosmetics is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 350 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Cosmetic ingredients
  • Nanotechnology
  • Nanobiotechnology
  • Natural polymers
  • Bio-nanocomposites
  • Natural raw materials
  • Natural cosmetics
  • Bio-cosmetics
  • Biodegradable packaging

Published Papers (1 paper)

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Open AccessArticle Safety Assessment of Nano-Hydroxyapatite as an Oral Care Ingredient according to the EU Cosmetics Regulation
Received: 26 July 2018 / Revised: 5 September 2018 / Accepted: 6 September 2018 / Published: 11 September 2018
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Hydroxyapatite nanoparticles (HAP-NP) are incorporated in oral care products such as toothpastes and mouthwashes to treat dental sensitivity or to promote enamel remineralisation. Despite the good performance of HAP-NP in this application, it is important to ensure its safety for consumers. For that
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Hydroxyapatite nanoparticles (HAP-NP) are incorporated in oral care products such as toothpastes and mouthwashes to treat dental sensitivity or to promote enamel remineralisation. Despite the good performance of HAP-NP in this application, it is important to ensure its safety for consumers. For that reason, the Scientific Committee on Consumer Safety (SCCS) evaluated the safety of HAP-NP as an oral care ingredient, but the issued opinion was not completely conclusive and the SCCS recommended that additional tests should be performed. Here, we used a commercially available human gingival epithelium (HGE) as a non-animal alternative and MTT cell viability, LDH activity, and IL-1alpha production were evaluated after 3.1% HAP-NP treatment for 10 min, 1 h, and 3 h. Moreover, the absorption of HAP-NP in the gingival tissue was assessed by transmission electron microscopy (TEM) analysis. Finally, the dissolution behaviour of HAP-NP in simulated gastric fluid was also investigated. No deleterious effect was observed for HGE tissues incubated with HAP-NP for all time-points and parameters evaluated. Moreover, a complete dissolution of 3.1% HAP-NP in simulated gastric fluid was observed after 7.5 min at 37 °C. In conclusion, our results evidence the safety of HAP-NP for oral care products with the use of an in vitro replacement alternative for human gingival epithelium and a simulated gastric fluid assay. Full article

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