Special Issue "Exosomes in Cancer Development"

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A special issue of Cancers (ISSN 2072-6694).

Deadline for manuscript submissions: closed (30 June 2013)

Special Issue Editors

Guest Editor
Prof. Dr. Pamela Russell

Australian Prostate Cancer Research Centre - Queensland and Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, QLD 4102, Austrialia
Website | E-Mail
Phone: +61 7 3443 7240
Fax: +61 7 3176 7440
Interests: advanced prostate cancer; plasma derived exosomes; urine derived exosomes, exosomes from animal models of cancer
Co-Guest Editor
Dr. Aled Clayton

Institute of Cancer & Genetics, School of Medicine, Cardiff University, Velindre Cancer Centre, Cardiff, CF14 2TL, UK
Website | E-Mail
Interests: cancer exosomes; tumour stroma; immune evasion; prostate cancer; mesothelioma

Special Issue Information

Dear Colleagues,

This issue invites investigators to contribute original research reports as well as review articles that describe studies on cancer exosomes.
Recent studies have shown that most cells constitutively secrete nanovesicles (50-150 nm) called exosomes through a distinct biogenesis pathway, not via the Golgi secretory pathway. The exosomal contents reflect the cells of origin. The release of exosomes is exacerbated in tumors leading to their increased presence in plasma, ascites, urine and other bodily fluids of cancer patients. However, the exosome field is still nascent, and lacks tools required for selective isolation of cancer-derived exosomes separate from other exosomes produced by other cells that are found in bodily fluids.
Recent advances in genomic, transcriptomic, proteomic, and metabolomic research pave the way to a more comprehensive understanding of the complex changes taking place in the locally involved cells and tissues, and of the interplay between the tumor and the rest of the organism. Exosomes have a double layered membrane containing an array of proteins, microRNA or mRNA, lipids, metabolites and potentially other tumor markers. Moreover, the exosomes are known to be involved in cell to cell interactions, including those which “educate” the tumor niche, encouraging the growth of tumor cells in secondary environments.
Potential topics include, but are not limited to:

  • Development of new techniques/assays for isolation of cancer-specific exosomes from bodily fluids and validation of these techniques against existing methodology.
  • Identification of novel prognostic biomarkers isolated from cancer derived exosomes in the  urine or circulation of cancer patients, eg that can predict metastases, or indicate treatment response and treatment resistance
  • Identification of cell to cell interactions between exosomes from cancer cells and other tissues and their role in cancer initiation or progression. These can include preclinical studies.
  • Studies that shed light on the mechanisms of release of exosomes from cancer cells.
  • Discussion of possible future developments based on studies of cancer specific exosomes towards a better understanding of cancer biology, and how such advances may be translated into improved patient management.

Prof. Dr. Pamela Russell
Guest Editor

Submission

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed Open Access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 800 CHF (Swiss Francs).

Keywords

  • cancer-specific exosome capture
  • exosomal biomarkers
  • exosomal miRNA
  • exosomal proteomics
  • exosomal metabolomics
  • exosomal lipidomics
  • cell to cell communications

Published Papers (2 papers)

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Research

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Open AccessArticle A Pilot Study on the Potential of RNA-Associated to Urinary Vesicles as a Suitable Non-Invasive Source for Diagnostic Purposes in Bladder Cancer
Cancers 2014, 6(1), 179-192; doi:10.3390/cancers6010179
Received: 21 October 2013 / Revised: 20 December 2013 / Accepted: 13 January 2014 / Published: 22 January 2014
Cited by 13 | PDF Full-text (570 KB) | HTML Full-text | XML Full-text | Supplementary Files
Abstract
Bladder cancer is one of the most common cancers and, together with prostate carcinoma, accounts for the majority of the malignancies of the genitourinary tract. Since prognosis ameliorates with early detection, it will be beneficial to have a repertoire of diagnostic markers that
[...] Read more.
Bladder cancer is one of the most common cancers and, together with prostate carcinoma, accounts for the majority of the malignancies of the genitourinary tract. Since prognosis ameliorates with early detection, it will be beneficial to have a repertoire of diagnostic markers that could complement the current diagnosis protocols. Recently, cell-secreted extracellular vesicles have received great interest as a source of low invasive disease biomarkers because they are found in many body fluids, including urine. The current work describes a pilot study to generate an array-based catalogue of mRNA associated to urinary vesicles, and also a comparison with samples obtained from bladder cancer patients. After an analysis of presence/absence of transcripts in bladder cancer EVs, a list of genes was selected for further validation using PCR technique. We found four genes differentially expressed in cancer samples. LASS2 and GALNT1 were present in cancer patients, while ARHGEF39 and FOXO3 were found only in non-cancer urinary vesicles. Previous studies have pointed to the involvement of those genes in tumour progression and metastasis. Full article
(This article belongs to the Special Issue Exosomes in Cancer Development)
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Review

Jump to: Research

Open AccessReview Exosomes in Prostate Cancer: Putting Together the Pieces of a Puzzle
Cancers 2013, 5(4), 1522-1544; doi:10.3390/cancers5041522
Received: 30 September 2013 / Revised: 21 October 2013 / Accepted: 1 November 2013 / Published: 11 November 2013
Cited by 21 | PDF Full-text (311 KB) | HTML Full-text | XML Full-text
Abstract
Exosomes have been shown to act as mediators for cell to cell communication and as a potential source of biomarkers for many diseases, including prostate cancer. Exosomes are nanosized vesicles secreted by cells and consist of proteins normally found in multivesicular bodies, RNA,
[...] Read more.
Exosomes have been shown to act as mediators for cell to cell communication and as a potential source of biomarkers for many diseases, including prostate cancer. Exosomes are nanosized vesicles secreted by cells and consist of proteins normally found in multivesicular bodies, RNA, DNA and lipids. As a potential source of biomarkers, exosomes have attracted considerable attention, as their protein content resembles that of their cells of origin, even though it is noted that the proteins, miRNAs and lipids found in the exosomes are not a reflective stoichiometric sampling of the contents from the parent cells. While the biogenesis of exosomes in dendritic cells and platelets has been extensively characterized, much less is known about the biogenesis of exosomes in cancer cells. An understanding of the processes involved in prostate cancer will help to further elucidate the role of exosomes and other extracellular vesicles in prostate cancer progression and metastasis. There are few methodologies available for general isolation of exosomes, however validation of those methodologies is necessary to study the role of exosomal-derived biomarkers in various diseases. In this review, we discuss “exosomes” as a member of the family of extracellular vesicles and their potential to provide candidate biomarkers for prostate cancer. Full article
(This article belongs to the Special Issue Exosomes in Cancer Development)

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