Metabolic Hallmarks of Malignant Cells

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Molecular Cancer Biology".

Deadline for manuscript submissions: closed (1 July 2023) | Viewed by 2021

Special Issue Editors


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Guest Editor
Department of Urology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
Interests: metabolism in cancer; metabolic therapies; metabolic imaging; metabolic phenotypes; mitochondria metabolism in oncology

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Guest Editor
Genitourinary Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA
Interests: metabolism in cancer; metabolic therapies; metabolic imaging; metabolic phenotypes; mitochondria metabolism in oncology

Special Issue Information

Dear Colleagues,

Changes in cellular metabolism are a hallmark of malignancy and are therefore fundamental to oncology. However, cellular metabolism is dynamic, with multiple pathways feeding each other to generate both small molecules and large macromolecules. Therefore, understanding and targeting metabolism is a difficult endeavor. The aim of the Special Issue is to discuss unique metabolic phenotypes in oncology, how these phenotypes are being translated into clinical treatments, how in vivo imaging can be used interrogate metabolism, and the correlation between metabolism and immune therapy. 

Cancers is in the process of generating a Special Issue focused on Metabolic Hallmarks of Malignant Cells.  As leaders in the field, you will be aware of the importance of metabolism in oncology. Changes in cellular metabolism are a hallmark of cancer, but due to its dynamic nature and the dual role of catabolism and anabolism, understanding and targeting metabolism is a difficult endeavor.  The aim of the Special Issue is to discuss unique metabolic phenotypes in oncology, how these phenotypes are being translated into clinical treatments, how in vivo imaging can be used interrogate metabolism, and the correlation between metabolism and immune therapy.  We are pleased to invite you to contribute original research articles, reviews, or perspectives based on this topic.  We look forward to receiving your contributions. 

Dr. Niki M. Zacharias Millward
Dr. Pavlos Msaouel
Guest Editors

Manuscript Submission Information

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Keywords

  • metabolism in cancer
  • metabolic therapies
  • metabolic imaging
  • metabolic phenotypes
  • mitochondria metabolism in oncology

Published Papers (1 paper)

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Research

18 pages, 4731 KiB  
Article
Mass Spectrometry Imaging Reveals Abnormalities in Cardiolipin Composition and Distribution in Astrocytoma Tumor Tissues
by Anna C. Krieger, Luis A. Macias, J. Clay Goodman, Jennifer S. Brodbelt and Livia S. Eberlin
Cancers 2023, 15(10), 2842; https://doi.org/10.3390/cancers15102842 - 19 May 2023
Cited by 1 | Viewed by 1464
Abstract
Cardiolipin (CL) is a mitochondrial lipid with diverse roles in cellular respiration, signaling, and organelle membrane structure. CL content and composition are essential for proper mitochondrial function. Deranged mitochondrial energy production and signaling are key components of glial cell cancers and altered CL [...] Read more.
Cardiolipin (CL) is a mitochondrial lipid with diverse roles in cellular respiration, signaling, and organelle membrane structure. CL content and composition are essential for proper mitochondrial function. Deranged mitochondrial energy production and signaling are key components of glial cell cancers and altered CL molecular species have been observed in mouse brain glial cell xenograft tumors. The objective of this study was to describe CL structural diversity trends in human astrocytoma tumors of varying grades and correlate these trends with histological regions within the heterogeneous astrocytoma microenvironment. To this aim, we applied desorption electrospray ionization coupled with high field asymmetric ion mobility mass spectrometry (DESI-FAIMS-MS) to map CL molecular species in human normal cortex (N = 29), lower-grade astrocytoma (N = 19), and glioblastoma (N = 28) tissues. With this platform, we detected 46 CL species and 12 monolysocardiolipin species from normal cortex samples. CL profiles detected from glioblastoma tissues lacked diversity and abundance of longer chain polyunsaturated fatty acid containing CL species when compared to CL detected from normal and lower-grade tumors. CL profiles correlated with trends in tumor viability and tumor infiltration. Structural characterization of the CL species by tandem MS experiments revealed differences in fatty acid and double bond isomer composition among astrocytoma tissues compared with normal cortex and glioblastoma tissues. The GlioVis platform was used to analyze astrocytoma gene expression data from the CGGA dataset. Decreased expression of several mitochondrial respiratory enzyme encoding-genes was observed for higher-grade versus lower-grade tumors, however no significant difference was observed for cardiolipin synthesis enzyme CRLS1. Full article
(This article belongs to the Special Issue Metabolic Hallmarks of Malignant Cells)
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