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7.4
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Cancers
Special Issues
Skin Cancer and Environmental Exposure
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Skin Cancer and Environmental Exposure

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Epidemiology and Prevention".

Deadline for manuscript submissions: 25 August 2024 | Viewed by 476

Special Issue Editors

Dr. Dimitra Koumaki

E-Mail Website
Guest Editor
Department of Dermatology, University Hospital of Heraklion, 71500 Heraklion, Greece
Interests: skin cancer; mela-noma and non-melanoma skin cancer; skin surgery
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Stamatis Gregoriou

E-Mail Website
Co-Guest Editor
Department of Dermatology and Venereology, Andreas Sygros Hospital, National and Kapodistrian University of Athens, Medical School of Athens, I. Dragoumi 5, 16121, Athens, Greece
Interests: skin cancer; mela-noma and non-melanoma skin cancer; atopic der-matitis; contact dermatitis
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Konstantin Krasagakis

E-Mail Website
Co-Guest Editor
Department of Dermatology, University General Hospital of Heraklion, 71500 Heraklion, Greece
Interests: skin cancer; melanoma and non-melanoma skin cancer

Special Issue Information

Dear Colleagues,

Skin cancer is intricately linked to environmental factors. Prolonged exposure to ultraviolet (UV) radiation from sunlight remains a primary contributor, with both UVA and UVB rays implicated in DNA damage and mutation accumulation, fostering the development of skin cancers, including melanoma and nonmelanoma skin cancer (NMSC). Environmental pollutants, such as industrial chemicals and particulate matter, also play roles in skin cancer pathogenesis, potentially interacting with genetic susceptibility. Understanding these complex interactions is crucial to devising effective preventive strategies and therapeutic interventions.

This Special Issue aims to explore the intricate relationship between skin cancer and various environmental exposures, shedding light on emerging research and innovative approaches in the field. We welcome original research articles and reviews that delve into the intersections of environmental factors and skin cancer etiology, prevention, and treatment. Join us in advancing our understanding of this critical health concern and contributing to the scientific dialogue that will inform future advancements in skin cancer research. Your valuable contributions will undoubtedly enrich this Special Issue.

Dr. Dimitra Koumaki
Prof. Dr. Stamatis Gregoriou
Prof. Dr. Konstantin Krasagakis
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • skin cancer
  • melanoma
  • non-melanoma skin cancer
  • environmental factors
  • ultraviolet (UV) radiation
  • DNA damage
  • etiology
  • prevention and treatment

Published Papers (1 paper)

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Review

15 pages, 3064 KiB  
Review
Skin Malignancies Due to Anti-Cancer Therapies
by Michela Starace, Luca Rapparini and Stephano Cedirian
Cancers 2024, 16(11), 1960; https://doi.org/10.3390/cancers16111960 - 22 May 2024
Viewed by 210
Abstract
Skin cancers involve a significant concern in cancer therapy due to their association with various treatment modalities. This comprehensive review explores the increased risk of skin cancers linked to different anti-cancer treatments, including classic immunosuppressants such as methotrexate (MTX), chemotherapeutic agents such as [...] Read more.
Skin cancers involve a significant concern in cancer therapy due to their association with various treatment modalities. This comprehensive review explores the increased risk of skin cancers linked to different anti-cancer treatments, including classic immunosuppressants such as methotrexate (MTX), chemotherapeutic agents such as fludarabine and hydroxyurea (HU), targeted therapies like ibrutinib and Janus Kinase inhibitors (JAKi), mitogen-activated protein kinase pathway (MAPKP) inhibitors, sonic hedgehog pathway (SHHP) inhibitors, and radiotherapy. MTX, a widely used immunosuppressant in different fields, is associated with basal cell carcinoma (BCC), cutaneous squamous cell carcinoma (cSCC), and cutaneous melanoma (CM), particularly at higher dosages. Fludarabine, HU, and other chemotherapeutic agents increase the risk of non-melanoma skin cancers (NMSCs), including cSCC and BCC. Targeted therapies like ibrutinib and JAKi have been linked to an elevated incidence of NMSCs and CM. MAPKP inhibitors, particularly BRAF inhibitors like vemurafenib, are associated with the development of cSCCs and second primary melanomas (SPMs). SHHP inhibitors like vismodegib have been linked to the emergence of cSCCs following treatment for BCC. Additionally, radiotherapy carries carcinogenic risks, especially for BCCs, with increased risks, especially with younger age at the moment of exposure. Understanding these risks and implementing appropriate screening is crucial for effectively managing patients undergoing anti-cancer therapies. Full article
(This article belongs to the Special Issue Skin Cancer and Environmental Exposure)
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