Recent Advances in Skin Cancers

Dear Colleagues,

While most cutaneous squamous cell carcinomas (cSCCs) are low-risk tumors and treated definitively with surgery, a subset of cSCC is associated with metastasis and death. In recent years, the introduction of the Brigham and Women’s Hospital tumor staging system and the updated American Joint Committee on Cancer guidelines have been instrumental in predicting the risk of poor outcomes from cSCC. Gene expression profile testing of cSCC can provide additional prognostic information to guide the implementation of surveillance strategies and adjuvant therapies. The use of immunotherapy, specifically the PD1 inhibitor cemiplimab, has been a game changer in the treatment of locally advanced or metastatic cSCC.

In this Special Issue, we will highlight major advances in the staging, prognostication, and treatment of cSCC.

Dr. Syril Keena T. Que
Guest Editor

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• cutaneous squamous cell carcinoma
• staging
• surgical treatment
• immunotherapy
• cemiplimab
• adjuvant radiation
• gene expression profile
• Brigham and Women’s Hospital tumor staging system
• American Joint Committee on Cancer staging system