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Cancers
Special Issues
Early Age Onset Cancers
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Early Age Onset Cancers

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Molecular Cancer Biology".

Deadline for manuscript submissions: closed (30 November 2023) | Viewed by 5041

Special Issue Editors

Prof. Dr. Des C. Winter

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Guest Editor
Centre for Colorectal Disease, St. Vincent's University Hospital, Elm Park, Dublin 4, Ireland
Interests: early age cancer; colorectal cancer; cancer immunology; molecular cancer biology
Dr. Alexandra M. Zaborowski

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Guest Editor
Department of Surgery, Royal College of Surgeons, Dublin, Ireland
Interests: early age cancer; breast cancer; cancer immunology; molecular cancer biology

Special Issue Information

Dear Colleagues,

For reasons not yet known, early age onset cancer is on the rise. Aetiology, biomolecular profile, treatment sensitivity, and prognosis are unclear as young patients have historically been underrepresented in clinical trials. They pose unique and important challenges associated with functional status, psychosocial well-being, and quality of life in survivorship. A particular emphasis of research in early-age cancer should be on appropriate multimodal treatment (with avoidance of overtreatment), a consideration of age-specific concerns and long-term treatment-related morbidities, and an identification of genetic mutations which may influence therapeutic decision making.

This Special Issue aims to present clinical and translational data relating to early age onset cancer with a specific focus on colorectal and breast cancer. Original research articles and reviews are welcome.

We look forward to receiving your contributions.

Prof. Dr. Des C. Winter
Dr. Alexandra M. Zaborowski
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • early age onset cancer
  • colorectal
  • breast
  • colorectal cancer
  • breast cancer

Published Papers (2 papers)

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Research

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10 pages, 257 KiB  
Communication
Colorectal Cancer in the Young: Research in Early Age Colorectal Cancer Trends (REACCT) Collaborative
by Alexandra M. Zaborowski
Cancers 2023, 15(11), 2979; https://doi.org/10.3390/cancers15112979 - 30 May 2023
Cited by 4 | Viewed by 1630
Abstract
Background: The incidence of colorectal cancer (CRC) is increasing in the young (under 50). Defining the clinicopathological features and cancer-specific outcomes of patients with early-onset CRC is important to optimize screening and treatment strategies. This study evaluated disease-specific features and oncological outcomes of [...] Read more.
Background: The incidence of colorectal cancer (CRC) is increasing in the young (under 50). Defining the clinicopathological features and cancer-specific outcomes of patients with early-onset CRC is important to optimize screening and treatment strategies. This study evaluated disease-specific features and oncological outcomes of patients with early-onset CRC. Methods: Anonymized data from an international collaboration were analyzed. The inclusion criteria for this study were patients aged <50 years with stage I-III disease surgically resected with curative intent. Overall and disease-free survival were calculated using the Kaplan–Meier method. Results: A total of 3378 patients were included, with a median age of 43 (18–49) and a slight male preponderance (54.3%). One-third had a family history of colorectal cancer. Almost all (>95%) of patients were symptomatic at diagnosis. The majority (70.1%) of tumors were distal to the descending colon. Approximately 40% were node positive. Microsatellite instability was demonstrated in one in five patients, representing 10% of rectal and 27% of colon cancers. A defined inherited syndrome was diagnosed in one-third of those with microsatellite instability. Rectal cancer displayed a worse prognosis stage for stage. Five-year disease-free survival for stage I, II, and III colon cancer was 96%, 91%, and 68%, respectively. The equivalent rates for rectal cancer were 91%, 81%, and 62%. Conclusions and relevance: The majority of EOCRC would be captured with flexible sigmoidoscopy. Extending screening to young adults and public health education initiatives are potential interventions to improve survivorship. Full article
(This article belongs to the Special Issue Early Age Onset Cancers)

Review

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14 pages, 1282 KiB  
Review
Oncotherapeutic Strategies in Early Onset Colorectal Cancer
by Mary O’Reilly, Anna Linehan, Aleksandar Krstic, Walter Kolch, Kieran Sheahan, Des C. Winter and Ray Mc Dermott
Cancers 2023, 15(2), 552; https://doi.org/10.3390/cancers15020552 - 16 Jan 2023
Cited by 8 | Viewed by 2998
Abstract
Early onset colorectal cancer (EOCRC), defined as colorectal cancers in patients aged less than 50 years, is becoming an increasingly common issue, globally. Since 1994, the incidence of this condition has been rising by 2% annually. Approximately one in five patients under 50 [...] Read more.
Early onset colorectal cancer (EOCRC), defined as colorectal cancers in patients aged less than 50 years, is becoming an increasingly common issue, globally. Since 1994, the incidence of this condition has been rising by 2% annually. Approximately one in five patients under 50 years of age diagnosed with colorectal cancer have an underlying genetic predisposition syndrome. The detection of cancer among the other 80% of patients poses a considerable task, as there is no family history to advocate for commencing early screening in this group. Patients with EOCRC have distinct social, spiritual, fertility, and financial needs from their older counterparts that need to be addressed. This review discusses the risk factors associated with the development of EOCRC and current best practice for the management of this disease. Full article
(This article belongs to the Special Issue Early Age Onset Cancers)
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