Special Issue "New Research in Obsessive-Compulsive Disorder and Major Depression"
A special issue of Brain Sciences (ISSN 2076-3425).
Deadline for manuscript submissions: closed (31 March 2018)
Prof. Dr. Bruno Aouizerate
Regional reference center for the management and treatment of anxiety and depressive disorders, Expert center for resistant depression (Foundation FondaMental), Charles Perrens Hospital, F-33076 Bordeaux, France
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Interests: immuno-inflammation; frontal-subcortical loops; cognition; motivation; major depression; obsessive–compulsive disorder
Major depression and obsessive–compulsive disorder (OCD) are now recognized among the most frequent psychiatric disorders, affecting 16–17% and 2–3% of the general population, respectively. They are commonly characterized by: i) a high level of psychiatric and somatic comorbidities; ii) a recurrence or chronic profile; and iii) a negative impact on daily functions, thereby leading to a profound impairment of quality of life. Despite significant advances in pharmacological and psychological therapies over the last decades, unsuccessful responses to standard treatment strategies are classically observed in approximately 20–30% of cases. Therefore, there is a significant need for improving the pathophysiological knowledge through a better identification of environmental, clinical, psychological, genetic, anatomical, and biological determinants, specifically implied in the development, the phenotypic expression, and the relapsing course and/or contributing to the therapeutic failure in major depression and OCD. We are convinced that this research approach is particularly relevant providing critical support for the promotion of innovative treatment alternatives potentially useful for the management of resistant forms of major depression and OCD. We thus encourage the submission of original research conducted in either humans or animal models, or updated reviews covering this topic for the present Special Issue.
Prof. Dr. Bruno Aouizerate
Prof. Dr. Emmanuel Haffen
Manuscript Submission Information
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- negative life events
- functional anatomy
- immune-inflammatory function
- stress-responsive neuroendocrine system
- clinical phenotype
- innovative treatments
- major depression
- obsessive-compulsive disorder