Nutritional Supplements as Novel Immunomodulators in Alzheimer’s Disease and Neuropsychiatric Disorders

Dear Colleagues,

Alzheimer's disease (AD) is a neurodegenerative disease characterized by the marked deposition of amyloid-β (Aβ) plaques and tau neurofibrillary tangles, and progressive cognitive impairment. The inflammatory response is also an important mechanism of AD pathogenesis. The development of current and future disease-modifying therapies is based on the modulation of these pathways. Several epidemiological studies have suggested that modifiable lifestyle diets such as moderate intake of nutritional supplements may reduce the relative risk of clinical dementia in AD. In experimental studies, for example, previous in vitro and in vivo studies using AD models showed that phenolic compounds inhibited fibrillization, oligomerization, and deposition of Aβ and tau, suggesting that dietary supplements such as polyphenols may have disease-modifying effects on AD pathogenesis. In this Special Issue, we seek submissions of original articles, reviews, and commentaries in both clinical and basic perspectives related to the disease-modifying effects of nutritional supplements for AD and neuropsychiatric disorders, including immunomodulated effects, which have recently attracted attention.

Prof. Dr. Kenjiro Ono
Dr. Moeko Noguchi-Shinohara
Prof. Dr. James E. Simon
Guest Editors

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• Alzheimer’s disease
• supplements
• amyloid-β
• tau
• microglia
• immunomodulator