Special Issue "Novel Insights in DNA Damage Response at the Crossroads of Gene Expression: Hints from the 6th EU-US DNA Repair Meeting"
A special issue of Biomolecules (ISSN 2218-273X).
Deadline for manuscript submissions: closed (15 April 2018)
Prof. Dr. Robert W. Sobol
Point Clear Charities Professor of Oncologic Sciences, Chief, Molecular & Metabolic Oncology Program, Abraham A. Mitchell Distinguished Investigator; University of South Alabama Mitchell
Website | E-Mail
Phone: (251) 445-9846 Laboratory Telephone: (251) 445-989
Interests: base excision repair, PARP and NAD+ metabolism in human cells; DNA damage induced by Geno toxins and chemotherapy
DNA is under constant attack from various exogenous and endogenous sources. Recent progress in whole genome sequencing has allowed many labs to identify an increasing array of cancer mutational signatures that serve as a high-resolution readout of the mutagenic processing of all of these sources of DNA damage that has accumulated over the lifetime of a patient. Moreover, specific signatures of DNA repair pathway alterations have emerged from these analyses thus revealing possible new targets for anticancer therapies. Interpreting these mutational signatures cannot be accomplished without a better understanding of the mechanisms involved in the formation or repair of such genome alterations. Various perturbations, originating from endogenous or exogenous sources, can interfere with the replication process, thus threatening genome integrity. Replication and the DNA damage response must be co-coordinated to ensure accurate DNA synthesis even under conditions of replication stress. Research is continuously identifying new factors involved in repair mechanisms/checkpoint machineries, which affect cell cycle progression until the damage is repaired.
The role of normal transcription and RNA processing in maintaining genome integrity is also becoming increasingly appreciated. We are only beginning to understand the nature and extent of the non-coding genome in human disease. New classes of RNAs and new regulatory mechanisms are emerging, expanding the known regulatory potential of small and long non-coding RNAs to encompass chromatin regulation. We are starting to learn that there are several variations of the DNA damage response (DDR) or the more global genomic stress response (GSR) in which pathways are activated by diverse cellular events and/or generates distinct signaling outcomes. In addition to cancer, defects in DNA repair and DDR pathways have been implicated in a wide array of diseases including neurodegeneration and age-related disorders. Recently, the DDR signaling cascade has been shown to function also in a paracrine manner triggering pro-inflammatory responses thus further extending its role in human health to metabolic diseases. Thus, there is reason to believe that the targeting of dysregulated repair/DDR processes may prove to be highly effective novel therapeutic approaches in the context of personalized medicine. A current challenge in our field is how to provide a holistic view of human health and disease considering that there are tens of thousands of chemicals in our environment. Exposures from our diet, our lifestyles, and our behaviors plus how our bodies respond to these challenges are currently assessed by evaluating the so-called exposome. This approach shows promise in deciphering disease mechanisms.
A major goal of this Special Issue is to describe the new frontiers in the molecular and cellular processes that affect genomic in human disease, in particular cancer, and the pathological changes associated with aging and genome instability in cancer. In particular, the emerging observations regarding the crosstalk between DNA Damage Response and Gene expression will be highlighted.
Papers will cover the following Topics:
- 1 - Replication Stress
- 2 - DNA editing: Mechanisms underlying mutational signatures in human cancers
- 3 - Regulatory mechanisms of RNA functions in genome stability
- 4 - Non-canonical action and novel regulators of DNA repair
- 5 - DNA damage, epigenetics and DNA repair
- 6 - Stability of the genome in aging and non-neoplastic disease
- 7 - Advanced technologies for analysis of DNA repair and the DNA damage response
- 8 - Poly(ADP-ribosyl)ation in the DNA damage response: Pre-clinical and translational aspects
- 9 - Defects in the DNA damage response as targets for personalized therapeutic approaches
- 10 - DNA repair and response to complex environmental genotoxins
Prof. Dr. Robert W. Sobol
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access quarterly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 650 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Replication stress
- DNA Editing
- RNA Metabolism
- Gene Expression
- DDR and Cancer
- DDR and Aging
- PARP in preclinical and clinical studies
- DDR and environmental toxins