Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
8.3
5.5
Journals
Biomolecules
Special Issues
Extracellular Matrix as Determinant for Tumor Cell Resistance
share announcement

Extracellular Matrix as Determinant for Tumor Cell Resistance

A special issue of Biomolecules (ISSN 2218-273X).

Deadline for manuscript submissions: closed (31 October 2019) | Viewed by 3675

Special Issue Editors

Prof. Dr. Gerd Bendas

E-Mail Website
Guest Editor
Pharmaceutical Department, University Bonn, 53121 Bonn, Germany
Interests: cancer metastasis; resistance; platelets; heparin; signaling pathways
Dr. Martin Schlesinger

E-Mail
Guest Editor
Pharmaceutical Department, University Bonn, 53121 Bonn, Germany
Interests: cancer metastasis; resistance; platelets; heparin; signaling pathways

Special Issue Information

Dear Colleagues,

The loss in sensitivity of tumor cells due to antineoplastic treatment regimes remains a major obstacle in the clinical treatment of cancer patients. Since tumor cells make use of multifaceted mechanisms to seek refuge from cytotoxic effects, a general rule for overcoming resistance does not exist in praxis. However, tumor cell embedding into a protective microenvironment appears as an initial, and probably consistent, process and premise for subsequent genetic resistance formation. Tumor cell binding to components of the extracellular matrix, referred to as, e.g., Cell Adhesion Mediated Drug Resistance (CAM-DR), as functional onset to escape cytotoxic stress, has increasingly attracted attention for its relevance to different tumor cell entities in recent years. The elucidation of several aspects of this topic remains challenging to accentuate matrix interactions as promising targets for future tumor sensitization strategies.

This Special Issue will highlight the most novel and promising developments in the field.

Prof. Dr. Gerd Bendas
Dr. Martin Schlesinger
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cancer
  • ECM
  • integrins
  • resistance
  • adhesion receptors

Published Papers (1 paper)

Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

17 pages, 2928 KiB  
Article
The Impact of Integrin-Mediated Matrix Adhesion on Cisplatin Resistance of W1 Ovarian Cancer Cells
by Kathleen Wantoch von Rekowski, Philipp König, Svenja Henze, Martin Schlesinger, Piotr Zawierucha, Radosław Januchowski and Gerd Bendas
Biomolecules 2019, 9(12), 788; https://doi.org/10.3390/biom9120788 - 26 Nov 2019
Cited by 19 | Viewed by 3206
Abstract
Background: Tumor cell binding to the microenvironment is regarded as the onset of therapeutic resistance, referred to as cell adhesion mediated drug resistance (CAM-DR). Here we elucidate whether CAM-DR occurs in ovarian cancer cells and contributes to still-existing cisplatin resistance. Methods: Cultivation of [...] Read more.
Background: Tumor cell binding to the microenvironment is regarded as the onset of therapeutic resistance, referred to as cell adhesion mediated drug resistance (CAM-DR). Here we elucidate whether CAM-DR occurs in ovarian cancer cells and contributes to still-existing cisplatin resistance. Methods: Cultivation of W1 and cisplatin-resistant W1CR human ovarian cancer cells on collagen-type I (COL1) was followed by whole genome arrays, MTT assays focusing cisplatin cytotoxicity, and AAS detection of intracellular platinum levels. Expression of cisplatin transporters Ctr1 and MRP2 was analyzed. Mechanistic insight was provided by lentiviral β1-integrin (ITGB1) knockdown, or inhibition of integrin-linked kinase (ILK). Results: EC50 values of cisplatin cytotoxicity increased twofold when W1 and W1CR cells were cultivated on COL1, associated with significantly diminished intracellular platinum levels. Transporter deregulation could not be detected at mRNA levels but appears partially responsible at protein levels. The ITGB1 knockdown confirms that CAM-DR follows a COL1/ITGB1 signaling axis in W1 cells; thus, a blockade of ILK re-sensitized W1 cells on COL1 for cisplatin. In contrast, CAM-DR adds to cisplatin resistance in W1CR cells independent of ITGB1. Conclusions: CAM-DR appears relevant for ovarian cancer cells, adding to existing genetic resistance and thus emerges as a target for sensitization strategies. Full article
(This article belongs to the Special Issue Extracellular Matrix as Determinant for Tumor Cell Resistance)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-1
Back to TopTop