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Biomolecules
Special Issues
Branched-Chain Amino Acids and Their Metabolites in Health and Disease
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Branched-Chain Amino Acids and Their Metabolites in Health and Disease

A special issue of Biomolecules (ISSN 2218-273X).

Deadline for manuscript submissions: closed (8 January 2020) | Viewed by 3921

Special Issue Editor

Prof. Dr. Milan Holeček

E-Mail Website
Guest Editor
Charles University, Department of Physiology, Prague Praha, Czech Republic
Interests: amino acids; liver cirrhosis; cachexia; nutritional supplements

Special Issue Information

Dear Colleagues,

Branched-chain amino acids (BCAAs; valine, leucine, and isoleucine) are essential amino acids reported to stimulate protein synthesis, attenuate protein breakdown, and regulate cellular signaling pathways. BCAAs and some of their metabolites, particularly, branched-chain keto acids and beta-hydroxy-beta-methylbutyrate (HMB), are advocated for therapeutic purposes in a number of disorders, such as liver cirrhosis, renal failure, sepsis, trauma, burn injury, and cancer. Furthermore, BCAAs and HMB are recognized as supplements for athletes and elderly people. However, until today, there have been controversies and differing viewpoints regarding BCAA metabolism in various metabolic states and the suitability of their supplementation in cancer, liver disorders, obesity, and type 2 diabetes mellitus.
The objective of this Special Issue is to bring together these controversies and differing viewpoints to stimulate further research toward their resolutions. We invite investigators to contribute high-quality original and review articles sharing their observations and exchanging ideas on BCAAs and BCAA metabolites to stimulate basic and clinical research in this field.

Prof. Dr. Milan Holeček
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • amino acids
  • branched-chain keto acids
  • supplements
  • beta-hydroxy-beta-methylbutyrate
  • nutrition.

Published Papers (1 paper)

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Research

14 pages, 1814 KiB  
Article
Maternal Leucine-Rich Diet Minimises Muscle Mass Loss in Tumour-bearing Adult Rat Offspring by Improving the Balance of Muscle Protein Synthesis and Degradation
by Natália Angelo da Silva Miyaguti, Sarah Christine Pereira de Oliveira and Maria Cristina Cintra Gomes-Marcondes
Biomolecules 2019, 9(6), 229; https://doi.org/10.3390/biom9060229 - 13 Jun 2019
Cited by 8 | Viewed by 3531
Abstract
Cachexia syndrome can affect cancer patients and new prevention strategies are required. Maternal nutritional supplementation can modify metabolic programming in the offspring, which lasts until adulthood. This could be a good approach against diseases such as cancer. A 3% leucine-rich diet treatment improved [...] Read more.
Cachexia syndrome can affect cancer patients and new prevention strategies are required. Maternal nutritional supplementation can modify metabolic programming in the offspring, which lasts until adulthood. This could be a good approach against diseases such as cancer. A 3% leucine-rich diet treatment improved muscle protein turnover by modifying the mTOR and proteolytic pathways, thus we analysed whether maternal supplementation could ameliorate muscle protein turnover in adult offspring tumour-bearing rats. Pregnant Wistar rats received a control diet or 3% leucine-rich diet during pregnancy/lactation, and their weaned male offspring received a control diet until adulthood when they were distributed into following groups (n = 7–8 per group): C, Control; W, tumour-bearing; L, without tumour with a maternal leucine-rich diet; and WL, tumour-bearing with a maternal leucine-rich diet. Protein synthesis and degradation were assessed in the gastrocnemius muscle, focusing on the mTOR pathway, which was extensively altered in W group. However, the WL adult offspring showed no decrease in muscle weight, higher food intake, ameliorated muscle turnover, activated mTOR and p70S6K, and maintained muscle cathepsin H and calpain activities. Maternal leucine nutritional supplementation could be a positive strategy to improve muscle protein balance in cancer cachexia-induced muscle damage in adult offspring rats. Full article
(This article belongs to the Special Issue Branched-Chain Amino Acids and Their Metabolites in Health and Disease)
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