Wnt Pathway Regulation in Development, Stem Cells and Cancer

Dear Colleagues,

We invite articles for this Special Issue, entitled, “Wnt Pathway regulation in Development, Stem Cells and Cancer”. The goal of this Special Issue is to explore the weird and wonderful of the Wnt signalling pathway across metazoans and what this tells us about Wnt pathway-driven cancers.

The Wnt pathway is an ancient, evolutionary conserved, cell–cell communication module in the development of metazoans that controls cell fate, organogenesis and tissue patterning. In adult tissues, the Wnt pathway coordinates precise geographic and temporal restriction of stem cell maintenance and function.

Developmental and stem cell functions of the Wnt pathway are often co-opted in certain cancers; for instance, de-regulation of stem cell proliferation and differentiation functions can be achieved through oncogenic mutation of components controlling Wnt pathway activity.

Through a deep understanding of Wnt pathway control, activity and function, we can obtain an appreciation of who, how and what goes wrong in the face of oncogenic mutations that drive carcinogenesis. Ultimately, this knowledge will provide the foundation for design of therapeutic strategies that target malignancy of Wnt pathway-driven cancers.

This Special Issue will encompass a series of review articles and research articles that explore Wnt pathway regulation and function in metazoans and highlight parallels with the oncogenic form of the pathway.

We look forward to your receiving your contributions.

Dr. Marc De La Roche
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• Wnt pathway regulation and function
• metazoan development
• stem cells
• Wnt pathway driven cancer