Special Issue "New aspects of the Hepatocyte Growth Factor/c-Met System"

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A special issue of Biomedicines (ISSN 2227-9059).

Deadline for manuscript submissions: closed (31 December 2014)

Special Issue Editors

Guest Editor
Dr. Giulia Ricci
Department of Experimental Medicine, Second University of Naples, Naples, Italy.
Website: http://www.medicina.unina2.it/Docenti/tabid/60/docid/437/language/it-IT/Default.aspx
E-Mail: giulia.ricci@unina2.it
Interests: growth factors, reproductive biology, embryonic development, testicular germ cell tumours

Guest Editor
Dr. Angela Catizone
Department of Anatomy, Histology, Forensic Medicine, and Orthopedics "Sapienza" University of Rome, Rome, Italy
Website: http://www.farmaciamedicina.uniroma1.it/?s=docenti&cognome=103
E-Mail: angela.catizone@uniroma1.it
Interests: growth factors, reproductive biology, embryonic development, testicular germ cell tumours

Guest Editor
Prof. Dr. Maria Prat
Department of Health Sciences Universitá del Piemonte Orientale, Novara, Italy
Website: http://www.neidos.it/index.pl?pos=03.01&ids=526
E-Mail: mprat@med.unipmn.it
Interests: Hepatocyte Growth Factor and its receptor in physiology and pathology, adults stem cells, cardiac tissue engineering, nanoparticle carriers

Guest Editor
Dr. Stefania Scarpino
Department of Clinical and Molecular Medicine "Sapienza" University of Rome Sant'Andrea Hospital, Rome, Italy
Website: http://www.ospedalesantandrea.it/index.php/sezione-utenti/dip-e-units/u-o-c-istologia-e-anatomia-patologica
E-Mail: stefania.scarpino@uniroma1.it
Interests: thyroid tumour; cancer genetic

Guest Editor
Dr. Rob Zachow
Department of Biochemistry and Molecular Biology/Office of Education Rutgers-RobertWood Johnson Medical School Piscataway, NJ, USA
Website: http://rwjms.rutgers.edu/education/current_students/office_directory/educ.html
E-Mail: zachowrj@rwjms.rutgers.edu
Interests: Endocrinology, reproductive endocrinology, steroidogenesis, ovarian follicular development

Guest Editor
Dr. Zimmer Yitzhak
Radiation Oncology Research Laboratory, Department of Clinical Research, University of Bern, Freiburgstrasse, Bern, Switzerland
Website: http://www.dkf.unibe.ch/index.php?id=281&lang=de&group_id=21&lang=en
E-Mail: Yitzhak.Zimmer@insel.ch
Interests: MET RTK, DNA Damage Response, Mechanisms of Treatment Resistance in Cancer, PTM proteomics

Special Issue Information

Dear Colleagues,

This Special Issue, "New Insights on the Many Faces of the HGF/c-Met System", will mainly focus on the several roles exerted by the Hepatocyte Growth Factor (HGF) in development homeostasis (and related diseases).

The Hepatocyte Growth Factor/c- Met (HGF/c-Met) system has been extensively studied in the past two decades and has been shown to mediate multiple biological activities, such as cellular proliferation, survival, motility, morphogenesis, and angiogenesis. These pleiotropic and complex physiological functions act together during organogenesis and tissue homeostasis but can give rise to a broad spectrum of pathologies when the HGF/c-Met system physiological balance is disrupted. Knowledge of the HGF/c-Met physiological and pathological activities, and the elucidation of the pathways mediating them, have enabled the development of several promising “HGF-based” molecules with therapeutic effects. Examples of such molecules include HGF variants or fragments, HGF chimeras, and c-Met agonists/antagonists. Thus, newly available biotechnologies can help us address the challenges of preventing organ failure and contrasting cancer. We thus consider this subject to be of particular interest; the topic can expand biomedicine toward new horizons.

We invite authors to submit original research and review articles that focus on the biological functions and therapeutic potential of the HGF/c-Met system (or related molecules). Potential topics include, but are not limited to:

  • HGF/c-Met system pathways;
  • The biochemical characteristics of HGF and c-Met;
  • The role of HGF in embryonic development and organogenesis;
  • The role of HGF in tissue regeneration, homeostasis, and repair;
  • HGF/c-Met in carcinogenesis;
  • Recent advances in cancer therapies, based on interference with the HGF/c-Met system’s biological functions.

Dr. Giulia Ricci
Dr. Angela Catizone
Prof. Dr. Maria Prat
Dr. Stefania Scarpino
Dr. Rob Zachow
Dr. Zimmer Yitzhak
Guest Editors

Submission

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed Open Access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. For the first couple of issues the Article Processing Charge (APC) will be waived for well-prepared manuscripts. English correction and/or formatting fees of 250 CHF (Swiss Francs) will be charged in certain cases for those articles accepted for publication that require extensive additional formatting and/or English corrections.

Published Papers (15 papers)

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Displaying article 1-15
p. 124-137
by , , , ,  and
Biomedicines 2015, 3(1), 124-137; doi:10.3390/biomedicines3010124
Received: 23 December 2014 / Accepted: 4 February 2015 / Published: 12 February 2015
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(This article belongs to the Special Issue New aspects of the Hepatocyte Growth Factor/c-Met System)
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p. 110-123
by , , , ,  and
Biomedicines 2015, 3(1), 110-123; doi:10.3390/biomedicines3010110
Received: 29 June 2014 / Revised: 29 September 2014 / Accepted: 27 January 2015 / Published: 4 February 2015
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(This article belongs to the Special Issue New aspects of the Hepatocyte Growth Factor/c-Met System)
p. 89-109
by , , , , ,  and
Biomedicines 2015, 3(1), 89-109; doi:10.3390/biomedicines3010089
Received: 29 September 2014 / Revised: 10 November 2014 / Accepted: 21 January 2015 / Published: 28 January 2015
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(This article belongs to the Special Issue New aspects of the Hepatocyte Growth Factor/c-Met System)
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p. 71-88
by , , , , ,  and
Biomedicines 2015, 3(1), 71-88; doi:10.3390/biomedicines3010071
Received: 30 September 2014 / Accepted: 9 December 2014 / Published: 22 January 2015
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(This article belongs to the Special Issue New aspects of the Hepatocyte Growth Factor/c-Met System)
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p. 46-70
by  and
Biomedicines 2015, 3(1), 46-70; doi:10.3390/biomedicines3010046
Received: 29 September 2014 / Accepted: 8 January 2015 / Published: 15 January 2015
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(This article belongs to the Special Issue New aspects of the Hepatocyte Growth Factor/c-Met System)
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p. 32-44
by  and
Biomedicines 2015, 3(1), 32-44; doi:10.3390/biomedicines3010032
Received: 29 September 2014 / Accepted: 24 December 2014 / Published: 5 January 2015
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(This article belongs to the Special Issue New aspects of the Hepatocyte Growth Factor/c-Met System)
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p. 1-31
by  and
Biomedicines 2015, 3(1), 1-31; doi:10.3390/biomedicines3010001
Received: 30 September 2014 / Accepted: 9 December 2014 / Published: 31 December 2014
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(This article belongs to the Special Issue New aspects of the Hepatocyte Growth Factor/c-Met System)
p. 384-402
by , ,  and
Biomedicines 2014, 2(4), 384-402; doi:10.3390/biomedicines2040384
Received: 29 August 2014 / Revised: 7 November 2014 / Accepted: 28 November 2014 / Published: 9 December 2014
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(This article belongs to the Special Issue New aspects of the Hepatocyte Growth Factor/c-Met System)
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p. 359-383
by ,  and
Biomedicines 2014, 2(4), 359-383; doi:10.3390/biomedicines2040359
Received: 6 October 2014 / Revised: 21 November 2014 / Accepted: 24 November 2014 / Published: 3 December 2014
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(This article belongs to the Special Issue New aspects of the Hepatocyte Growth Factor/c-Met System)
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p. 345-358
by , , ,  and
Biomedicines 2014, 2(4), 345-358; doi:10.3390/biomedicines2040345
Received: 22 August 2014 / Revised: 11 November 2014 / Accepted: 17 November 2014 / Published: 25 November 2014
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(This article belongs to the Special Issue New aspects of the Hepatocyte Growth Factor/c-Met System)
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p. 327-344
by ,  and
Biomedicines 2014, 2(4), 327-344; doi:10.3390/biomedicines2040327
Received: 30 September 2014 / Revised: 3 November 2014 / Accepted: 6 November 2014 / Published: 14 November 2014
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(This article belongs to the Special Issue New aspects of the Hepatocyte Growth Factor/c-Met System)
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p. 301-326
by ,  and
Biomedicines 2014, 2(4), 301-326; doi:10.3390/biomedicines2040301
Received: 19 August 2014 / Revised: 21 October 2014 / Accepted: 27 October 2014 / Published: 5 November 2014
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(This article belongs to the Special Issue New aspects of the Hepatocyte Growth Factor/c-Met System)
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p. 275-300
by , ,  and
Biomedicines 2014, 2(4), 275-300; doi:10.3390/biomedicines2040275
Received: 25 August 2014 / Revised: 15 September 2014 / Accepted: 13 October 2014 / Published: 31 October 2014
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(This article belongs to the Special Issue New aspects of the Hepatocyte Growth Factor/c-Met System)
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p. 263-274
by  and
Biomedicines 2014, 2(4), 263-274; doi:10.3390/biomedicines2040263
Received: 12 September 2014 / Revised: 6 October 2014 / Accepted: 17 October 2014 / Published: 24 October 2014
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(This article belongs to the Special Issue New aspects of the Hepatocyte Growth Factor/c-Met System)
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p. 247-262
by , ,  and
Biomedicines 2014, 2(4), 247-262; doi:10.3390/biomedicines2040247
Received: 19 August 2014 / Revised: 18 September 2014 / Accepted: 13 October 2014 / Published: 21 October 2014
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(This article belongs to the Special Issue New aspects of the Hepatocyte Growth Factor/c-Met System)
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Last update: 7 January 2015

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