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Biomedicines 2014, 2(4), 247-262; doi:10.3390/biomedicines2040247

HGF/Met Axis in Heart Function and Cardioprotection

1
Department of Oncology, University of Turin, Corso Massimo D'Azeglio 52, 10126 Turin, Italy
2
Department of Medical Sciences, University of Turin, Corso Dogliotti 14, 10126 Turin, Italy
*
Author to whom correspondence should be addressed.
Received: 19 August 2014 / Revised: 18 September 2014 / Accepted: 13 October 2014 / Published: 21 October 2014
(This article belongs to the Special Issue New aspects of the Hepatocyte Growth Factor/c-Met System)
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Abstract

Hepatocyte growth factor (HGF) and its tyrosine kinase receptor (Met) play important roles in myocardial function both in physiological and pathological situations. In the developing heart, HGF influences cardiomyocyte proliferation and differentiation. In the adult, HGF/Met signaling controls heart homeostasis and prevents oxidative stress in normal cardiomyocytes. Thus, the possible cardiotoxicity of current Met-targeted anti-cancer therapies has to be taken in consideration. In the injured heart, HGF plays important roles in cardioprotection by promoting: (1) prosurvival (anti-apoptotic and anti-autophagic) effects in cardiomyocytes, (2) angiogenesis, (3) inhibition of fibrosis, (4) anti-inflammatory and immunomodulatory signals, and (5) regeneration through activation of cardiac stem cells. Furthermore, we discuss the putative role of elevated HGF as prognostic marker of severity in patients with cardiac diseases. Finally, we examine the potential of HGF-based molecules as new therapeutic tools for the treatment of cardiac diseases. View Full-Text
Keywords: hepatocyte growth factor; Met tyrosine kinase receptor; heart development; cardiotoxicity; cardioprotection; myocardial infarction; angiogenesis; fibrosis; inflammation; cardiac regeneration hepatocyte growth factor; Met tyrosine kinase receptor; heart development; cardiotoxicity; cardioprotection; myocardial infarction; angiogenesis; fibrosis; inflammation; cardiac regeneration
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Gallo, S.; Sala, V.; Gatti, S.; Crepaldi, T. HGF/Met Axis in Heart Function and Cardioprotection. Biomedicines 2014, 2, 247-262.

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