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Biomedicines 2015, 3(1), 149-181; doi:10.3390/biomedicines3010149

Recent Progress and Advances in HGF/MET-Targeted Therapeutic Agents for Cancer Treatment

1
Department of Clinical Pharmacology, Modeling and Simulation, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320, USA
2
Kite Pharma, Inc., 2225 Colorado Avenue, Santa Monica, CA 90404, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Giulia Ricci
Received: 22 January 2015 / Revised: 25 February 2015 / Accepted: 3 March 2015 / Published: 19 March 2015
(This article belongs to the Special Issue New aspects of the Hepatocyte Growth Factor/c-Met System)
View Full-Text   |   Download PDF [1248 KB, uploaded 19 March 2015]   |  

Abstract

The hepatocyte growth factor (HGF): MET axis is a ligand-mediated receptor tyrosine kinase pathway that is involved in multiple cellular functions, including proliferation, survival, motility, and morphogenesis. Aberrancy in the HGF/MET pathway has been reported in multiple tumor types and is associated with tumor stage and prognosis. Thus, targeting the HGF/MET pathway has become a potential therapeutic strategy in oncology development in the last two decades. A number of novel therapeutic agents—either as therapeutic proteins or small molecules that target the HGF/MET pathway—have been tested in patients with different tumor types in clinical studies. In this review, recent progress in HGF/MET pathway-targeted therapy for cancer treatment, the therapeutic potential of HGF/MET-targeted agents, and challenges in the development of such agents will be discussed. View Full-Text
Keywords: HGF; MET; cancer treatment; new therapeutic agents; biomarker HGF; MET; cancer treatment; new therapeutic agents; biomarker
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Zhang, Y.; Jain, R.K.; Zhu, M. Recent Progress and Advances in HGF/MET-Targeted Therapeutic Agents for Cancer Treatment. Biomedicines 2015, 3, 149-181.

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