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Applied Sciences
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Advances in Biological Activities of Natural Products
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Advances in Biological Activities of Natural Products

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Chemical and Molecular Sciences".

Deadline for manuscript submissions: 20 October 2024 | Viewed by 2755

Special Issue Editor

Prof. Dr. Francisco Cruz-Sosa

E-Mail Website
Guest Editor
Departmento of Biotechnology, Metropolitan Autonomous University Iztapalapa Campus, Av. Ferrocarril de San Rafael Atlixco 186, Mexico City 09310, Mexico
Interests: plant cell cultures; secondary metabolites; biological activity
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Medicinal plants have great significance in the health industry. Almost 25% of modern medicines are obtained or derived from natural sources. The chemical entities responsible for the biological activity of medicinal plants are organic molecules classified as natural products. Although there are more than 50,000 plant species used for medicinal purposes, bioactive compounds in plant tissues generally account for less than 1% (wt.), leading to the overexploitation, threatening, or extinction of vegetal species. Therefore, it is important to develop strategies that allow the production of secondary metabolites in more sustainable and better controlled processes. This Special Issue on “Advances in the Biological Activities of Natural Products” aims to assess the current state of the art in the study of natural products and their potential application due to their biological activity.

We invite authors to submit original research and review articles covering (but not limited to) the following topics: the biological activity of natural products from wild plants, the biological activity of plant extracts, and the biological activity of natural products from plant cell cultures.

Prof. Dr. Francisco Cruz-Sosa
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biological activity
  • bioactive compounds
  • medicinal plants
  • natural products
  • plant cell cultures
  • secondary metabolites

Published Papers (2 papers)

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Research

10 pages, 1759 KiB  
Article
Variability in Phytochemical Contents and Biological Activities among Adenophora triphylla Genotypes
by Oluwadamilola Elizabeth Ajayi, Seon Young Yoon, Suyun Moon, Ki Hyun Kim, Jung Hwan Kim, Jong-Wook Chung, Keum-Il Jang and Tae Kyung Hyun
Appl. Sci. 2023, 13(20), 11184; https://doi.org/10.3390/app132011184 - 11 Oct 2023
Cited by 1 | Viewed by 851
Abstract
Genetic diversity can remarkably impact the quality of derived products. This study focused on Adenophora triphylla, an herbaceous perennial used in East Asian traditional medicine. It is known for its diverse therapeutic effects that are attributed to phytochemicals. However, despite its therapeutic [...] Read more.
Genetic diversity can remarkably impact the quality of derived products. This study focused on Adenophora triphylla, an herbaceous perennial used in East Asian traditional medicine. It is known for its diverse therapeutic effects that are attributed to phytochemicals. However, despite its therapeutic potential, a comprehensive exploration of the influence of genetic diversity on the pharmaceutical properties of various A. triphylla genotypes remains unknown. To address this knowledge gap, we employed DNA barcoding regions (ITS2, matK, and psbA-trnH) to elucidate the genetic diversity among the collected genotypes. The combined application of these barcoding regions is a robust method to identify A. triphylla genotypes. In addition, leaf extracts consistently exhibited higher antioxidant potential than root extracts. Nitric oxide production was strongly inhibited by the leaf extracts of the BG genotype (IC50 = 124.52 ± 12.97 µg/mL), and the leaf extracts (200 µg/mL) of the BT genotype contained significant antimelanogenic properties (IC50 = 181.56 ± 16.17 µg/mL). Various genotypes displayed diverse levels of phytochemical content, and the total saponin content exhibited a strong correlation with various biological activities of A. triphylla, suggesting a genetic influence on their pharmaceutical attributes. These findings highlight the significance of genotype selection for optimizing health benefits and promoting the potential utilization of specific genotypes in various industries, such as cosmetics and pharmaceuticals. Full article
(This article belongs to the Special Issue Advances in Biological Activities of Natural Products)
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16 pages, 1958 KiB  
Article
Alkaloid and Nitrogenated Compounds from Different Sections of Coryphantha macromeris Plants and Callus Cultures
by Valeria Viera-Escareño, Eugenio Perez-Molphe Balch, Yenny Adriana Gómez-Aguirre, Oscar Javier Ramos-Herrera, Gholamreza Abdi, Francisco Cruz-Sosa and Emmanuel Cabañas-García
Appl. Sci. 2023, 13(17), 9947; https://doi.org/10.3390/app13179947 - 02 Sep 2023
Viewed by 1209
Abstract
One of the distinctive characteristics of cacti species is the presence of alkaloids. Alkaloids are nitrogenated molecules with hallucinogenic and pharmacological properties in humans and other animals. Plant cell, tissue, and organ culture have emerged as an effective tool for investigating the biosynthesis [...] Read more.
One of the distinctive characteristics of cacti species is the presence of alkaloids. Alkaloids are nitrogenated molecules with hallucinogenic and pharmacological properties in humans and other animals. Plant cell, tissue, and organ culture have emerged as an effective tool for investigating the biosynthesis of a variety of functional metabolites and for studying the preservation of endangered plant species. In this study, we examined the alkaloid and nitrogenated compound profiles of the aerial and radicular sections of Coryphantha macromeris plants that were cultivated in both greenhouse and in vitro conditions. Additionally, we analyzed the callus cultures generated from stem discs. To perform these analyses, Ultra-High-Performance Liquid Chromatography coupled with High-Resolution Mass Spectrometry (UHPLC-PDA-HESI-Orbitrap-MS/MS) was utilized. Under the working parameters, 78 compounds were detected, and 61 of them were identified. Among the identified compounds, the in vitro plants presented 24 compounds, greenhouse plants a total of 21 compounds, and callus tissue 16 compounds. On the other hand, 7 compounds (laurydiethanolamine, toluic acids, and their derivatives) were detected in all systems, suggesting that these metabolites may serve as markers to help find the authenticity of C. macromeris preparations, and that, plant and cell-tissue cultures with this plant species are suitable for the biosynthesis of the selected compounds. In addition, our research suggests that no alkaloids with reported psychotropic properties are present in C. macromeris. Full article
(This article belongs to the Special Issue Advances in Biological Activities of Natural Products)
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