Special Issue "Free Radicals and Antioxidants in Neuroinflammation"


A special issue of Antioxidants (ISSN 2076-3921).

Deadline for manuscript submissions: closed (28 February 2014)

Special Issue Editors

Guest Editor
Prof. Dr. Jack van Horssen
Department of Molecular Cell Biology and Immunology, VU University Medical Center Amsterdam, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
Website: http://www.vumc.nl/afdelingen/moleculairecelbiologie/Research-MCBI/Elga-de-Vries-group/Jack-van-Horssen-research/
E-Mail: j.vanhorssen@vumc.nl
Phone: +31 204448078
Fax: +31 204448081
Interests: immunohistochemistry; neuropathology; neuroinflammation; mitochondrial dysfunction; Nrf2; antioxidant enzymes; multiple sclerosis

Co-Guest Editor
Dr. Maarten E. Witte
Department of Molecular Cell Biology and Immunology, VU University Medical Center Amsterdam, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
E-Mail: m.witte@vumc.nl
Phone: +31 20 4449998
Fax: +31 20 4448081
Interests: neuroinflammation; neurodegeneration; mitochondrial biology; energy metabolism; oxidative stress

Special Issue Information

Dear Colleagues,

Reactive oxygen species (ROS) are continuously produced in the central nervous system (CNS) by ROS-generating enzymes, such as NADPH oxidases, and by mitochondria. Importantly, ROS are efficiently detoxified by endogenous cytosolic and mitochondrial antioxidant enzymes in order to prevent oxidative injury to vulnerable CNS cells. However, in neuroinflammatory diseases, ROS production exceeds the antioxidant capacity. This results in irreversible oxidative damage to essential cellular structures, and eventually leads to neuronal loss. The aim of this special issue is to provide a comprehensive overview on the involvement of oxidative stress in neuroinflammatory conditions. Specific topics include:

1. Elucidation of the (sub)cellular origin of ROS during a neuroinflammatory attack and the molecular processes that are involved in this process.

2. Therapeutic potential of endogenous antioxidants in neuroinflammation, including transcriptional regulation of antioxidant enzymes, such as the Nrf2 and PGC-1α pathway.

Prof. Dr. Jack van Horssen
Dr. Maarten E. Witte
Guest Editor


Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed Open Access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. For the first couple of issues the Article Processing Charge (APC) will be waived for well-prepared manuscripts. English correction and/or formatting fees of 250 CHF (Swiss Francs) will be charged in certain cases for those articles accepted for publication that require extensive additional formatting and/or English corrections.


  • neurodegenerative diseases (Parkinson, Alzheimer)
  • ROS-generating enzymes (NADPH oxidase, NOS)
  • neuroinflammation
  • Nrf2 and PCG-alpha pathway
  • exogenous antioxidants
  • mitochondrial antioxidants
  • microglia activation
  • meningeal inflammation
  • antioxidant therapy
  • oxidative stress

Published Papers

No papers have been published in this special issue yet.

Last update: 10 September 2013

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