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Antioxidants
Special Issues
Oxidative Stress and Liver Disease
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Oxidative Stress and Liver Disease

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".

Deadline for manuscript submissions: 30 September 2024 | Viewed by 433

Special Issue Editor

Dr. Alejandra Espinosa Escalona

E-Mail Website
Guest Editor
Center of Interdisciplinary Biomedical and Engineering Research for Health, Faculty of Medicine, Campus San Felipe, Universidad de Valparaíso, Valparaíso 2340000, Chile
Interests: antioxidants; liver diseases; insulin resistance

Special Issue Information

Dear Colleagues,

We are pleased to announce a Special Issue of Antioxidants that focuses on antioxidants and liver disease. Metabolic dysfunction-associated fatty liver disease (MAFLD), a term coined in 2018, has replaced nonalcoholic fatty liver disease (NAFLD). Chronic liver diseases of metabolic origin have diverse causes, including genetics, epigenetics, and the composition of the microbiota. Oxidative stress has been implicated in disease progression by several mechanisms associated with hepatocyte damage. The recent pandemic, which led to prolonged periods of lockdown and sedentary lifestyles, further exacerbated the risk factors of obesity and metabolic syndrome, both of which are associated with an increase in oxidative stress. All three contribute to liver disease progression, especially when combined with increased alcohol consumption, a lack of exercise, being elderly, and a number of other risk factors. We invite submissions to this Special Issue of original research articles, reviews, and case studies related to MAFLD, antioxidants, liver damage mechanisms, etc. Contributions exploring the latest advancements in our understanding of the pathogenesis, diagnosis, treatment, and prevention of liver disease are particularly welcome. We look forward to your valuable contributions to this important area of research.

Sincerely,

Dr. Alejandra Espinosa Escalona
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • oxidative stress
  • antioxidants
  • MAFLD
  • NAFLD
  • obesity

Published Papers (1 paper)

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Research

19 pages, 2509 KiB  
Article
The Interplay between Perioperative Oxidative Stress and Hepatic Dysfunction after Human Liver Resection: A Prospective Observational Pilot Study
by Florian Primavesi, Thomas Senoner, Sophie Schindler, Aleksandar Nikolajevic, Pietro Di Fazio, Georg Csukovich, Silvia Eller, Bettina Neumayer, Markus Anliker, Eva Braunwarth, Rupert Oberhuber, Thomas Resch, Manuel Maglione, Benno Cardini, Thomas Niederwieser, Silvia Gasteiger, Eckhard Klieser, Herbert Tilg, Stefan Schneeberger, Daniel Neureiter, Dietmar Öfner, Jakob Troppmair and Stefan Stättneradd Show full author list remove Hide full author list
Antioxidants 2024, 13(5), 590; https://doi.org/10.3390/antiox13050590 (registering DOI) - 11 May 2024
Viewed by 276
Abstract
Post-hepatectomy liver failure (PHLF) remains the major contributor to death after liver resection. Oxidative stress is associated with postoperative complications, but its impact on liver function is unclear. This first in-human, prospective, single-center, observational pilot study evaluated perioperative oxidative stress and PHLF according [...] Read more.
Post-hepatectomy liver failure (PHLF) remains the major contributor to death after liver resection. Oxidative stress is associated with postoperative complications, but its impact on liver function is unclear. This first in-human, prospective, single-center, observational pilot study evaluated perioperative oxidative stress and PHLF according to the ISGLS (International Study Group for Liver Surgery). Serum 8-isoprostane, 4-hydroxynonenal (4-HNE), total antioxidative capacity, vitamins A and E, and intraoperative, sequential hepatic tissue 4-HNE and UCP2 (uncoupling protein 2) immunohistochemistry (IHC) were assessed. The interaction with known risk factors for PHLF and the predictive potential of oxidative stress markers were analyzed. Overall, 52 patients were included (69.2% major liver resection). Thirteen patients (25%) experienced PHLF, a major factor for 90-day mortality (23% vs. 0%; p = 0.013). Post-resection, pro-oxidative 8-isoprostane significantly increased (p = 0.038), while 4-HNE declined immediately (p < 0.001). Antioxidative markers showed patterns of consumption starting post-resection (p < 0.001). Liver tissue oxidative stress increased stepwise from biopsies taken after laparotomy to post-resection in situ liver and resection specimens (all p < 0.001). Cholangiocarcinoma patients demonstrated significantly higher serum and tissue oxidative stress levels at various timepoints, with consistently higher preoperative values in advanced tumor stages. Combining intraoperative, post-resection 4-HNE serum levels and in situ IHC early predicted PHLF with an AUC of 0.855 (63.6% vs. 0%; p < 0.001). This was also associated with grade B/C PHLF (36.4% vs. 0%; p = 0.021) and 90-day mortality (18.2% vs. 0%; p = 0.036). In conclusion, distinct patterns of perioperative oxidative stress levels occur in patients with liver dysfunction. Combining intraoperative serum and liver tissue markers predicts subsequent PHLF. Cholangiocarcinoma patients demonstrated pronounced systemic and hepatic oxidative stress, with increasing levels in advanced tumor stages, thus representing a worthwhile target for future exploratory and therapeutic studies. Full article
(This article belongs to the Special Issue Oxidative Stress and Liver Disease)
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