Special Issue "Modes of Antibody Action for Cancer Therapy"
A special issue of Antibodies (ISSN 2073-4468).
Deadline for manuscript submissions: closed (31 March 2013)
Prof. Dr. Patrick A. Baeuerle
AMGEN Research (Munich) GmbH, Staffelseestr. 2, 81477 Munich, Germany
Phone: +49 89 895277-601
Fax: +49 89 895277-88601
Interests: bispecific antibodies; T cells; antibody drug conjugates; Fc-engineered antibodies; cancer therapy; antibody targets
Antibody-based therapies have high potential to treat malignant diseases. Very different modes of action can be employed to this end. There are intrinsic properties of antibodies such as ADCC, which can be enhanced by Fc gamma engineering, CDC, or an anti-apoptotic activity induced by antibody binding to a specific target antigen. There are also ways of bolting onto antibodies toxic compounds for improving efficacy. Conjugation of antibodies with plant or bacterial toxins leads to immunotoxins, with chemotherapeutics to antibody drug conjugates (ADCs), and with radioisotopes to radioimmunoconjugates. Bispecific antibodies have the potential to inhibit at a time two receptors, neutralize two angiogenic factors, or combinations thereof. Bispecific antibodies can also be used to tether T cells to cancer target cells, which is not possible with conventional antibodies. Lastly, antibodies binding to immune regulatory receptors can significantly support natural or antibody-mediated immune reactions against tumors. For each class, there are now drug candidates under late-stage development, or on the market. A special issues with focus on "modes of antibody action against cancer" will review recent developments and allow comparison of these different modes of action.
Prof. Dr. Patrick A. Baeuerle
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibodies is an international peer-reviewed Open Access quarterly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. For the first couple of issues the Article Processing Charge (APC) will be waived for well-prepared manuscripts. English correction and/or formatting fees of 250 CHF (Swiss Francs) will be charged in certain cases for those articles accepted for publication that require extensive additional formatting and/or English corrections.
- antibody-dependent cellular cytotoxicity (ADCC)
- complement-dependent cytotoxicity (CDC)
- antibody drug conjugates
- radioimmuno conjugates
- Fc gamma engineering
- bispecific antibodies
- T or NK cell engaging antibodies
- immune-stimulating antibodies
Antibodies 2012, 1(1), 39-69; doi:10.3390/antib1010039
Received: 28 March 2012; in revised form: 1 May 2012 / Accepted: 8 May 2012 / Published: 15 May 2012| Download PDF Full-text (1096 KB) | Download XML Full-text
Antibodies 2012, 1(1), 70-87; doi:10.3390/antib1010070
Received: 27 April 2012; in revised form: 15 May 2012 / Accepted: 17 May 2012 / Published: 31 May 2012| Download PDF Full-text (311 KB) | Download XML Full-text
Antibodies 2012, 1(1), 88-123; doi:10.3390/antib1010088
Received: 19 April 2012; in revised form: 21 May 2012 / Accepted: 24 May 2012 / Published: 1 June 2012| Download PDF Full-text (518 KB) | Download XML Full-text
Review: Alpha Particle Emitter Radiolabeled Antibody for Metastatic Cancer: What Can We Learn from Heavy Ion Beam Radiobiology?
Antibodies 2012, 1(2), 124-148; doi:10.3390/antib1020124
Received: 3 May 2012; in revised form: 17 June 2012 / Accepted: 20 June 2012 / Published: 26 June 2012| Download PDF Full-text (350 KB) | Download XML Full-text
Antibodies 2012, 1(2), 149-171; doi:10.3390/antib1020149
Received: 13 June 2012; in revised form: 26 June 2012 / Accepted: 26 June 2012 / Published: 4 July 2012| Download PDF Full-text (507 KB) | Download XML Full-text
Antibodies 2013, 2(2), 371-391; doi:10.3390/antib2020371
Received: 4 April 2013; in revised form: 13 May 2013 / Accepted: 14 May 2013 / Published: 28 May 2013| Download PDF Full-text (299 KB) | Download XML Full-text
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Type of Paper: Review
Title: Role and Redirection of IgE Against Cancer
Author: Luca Vangelista
Affiliation: San Raffaele Scientific Institute, Milan, Italy
Abstract: IgE is a highly elusive antibody isotype, yet a tremendously powerful elicitor of immune reactions. Despite huge efforts spent on the characterization and understanding of the IgE system many questions remain either unanswered or only marginally addressed. One above all relates to the role of IgE. A common doubt is based on whether IgE mode of action should only be relegated to anti-parasite immunity and allergic manifestations. In search for a hidden role of IgE, reports from several laboratories are described herein in which a natural IgE link to cancer or the experimental redirection of IgE against cancer have been investigated. Epidemiological and investigational studies are trying to elucidate a possible direct intervention of endogenous IgE against cancer, raising thus far no definitive evidence. Conversely, experimental approaches implementing several strategies and engineered IgE formats built up a series of convincing results indicating that cancer might be tackled by the effector functions of this immunoglobulin isotype. Because of its peculiar immune features, IgE may present a superior anti-tumor performance as compared to IgG. However, extreme care should be taken on how IgE-based anti-tumor approaches should be devised. Overall, IgE appears as a promising resource, likely destined to enrich the anti-cancer arsenal.
Type of Paper: Review
Title: IgG Effector Function Dictated by the Fc Glycan Composition
Authors: Kai-Ting Chuang and Robert M. Anthony
Affiliation: Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA
Abstract: IgG antibodies are the basis for some of the most effective therapeutics developed over the last 20 years. These proteins are highly specific, have long serum-half lives, and can be produced relatively routinely, making them ideal drugs. Importantly, the effector functions that are elicited by IgG antibodies can be enhanced or manipulated by the composition of the single, N-linked glycan attached to the Fc. IgG antibodies with identical protein sequences can gain 50- fold increased potency, in terms of initiating antibody-dependent cytotoxicity, by removing a single, specific sugar moiety from the Fc glycan. Conversely, the addition of sialic acid to the terminus of the Fc glycan converts IgG antibodies into anti-inflammatory mediators, capable of suppressing autoantibody driven inflammation. This review will discuss the contribution of the Fc glycan to IgG antibody effector functions, the regulation of the Fc glycan in vivo, and implications for the rationale design of IgG antibody-based therapeutics.
Last update: 28 November 2012