Next Article in Journal
Next Article in Special Issue
Previous Article in Journal
Antibodies 2012, 1(1), 39-69; doi:10.3390/antib1010039
Review

Antibody-Based Immunotoxins for the Treatment of Cancer

 and *
Received: 28 March 2012; in revised form: 1 May 2012 / Accepted: 8 May 2012 / Published: 15 May 2012
(This article belongs to the Special Issue Modes of Antibody Action for Cancer Therapy)
View Full-Text   |   Download PDF [1096 KB, updated 16 May 2012; original version uploaded 15 May 2012]   |   Browse Figures
Abstract: Antibody-based immunotoxins comprise an important group in targeted cancer therapeutics. These chimeric proteins are a form of biological guided missiles that combine a targeting moiety with a potent effector molecule. The targeting moiety is mostly a monoclonal antibody (MAb) or a recombinant antibody-based fragment that confers target specificity to the immunotoxin. The effector domain is a potent protein toxin of bacterial or plant origin, which, following binding to the target cells, undergoes internalization and causes cell death. Over time and following research progression, immunotoxins become better fitted to their purpose, losing immunogenic fragments and non-specific targeting moieties. Many immunotoxins have gone through clinical evaluation. Some of these have been shown to be active and work is progressing with them in the form of further clinical trials. Others, mostly developed in the previous century, failed to generate a response in patients, or even caused undesired side effects. This article reviews the antibody and protein-toxin based immunotoxins that were clinically evaluated up to the present day.
Keywords: immunotoxin; cancer therapy; clinical trials; monoclonal antibody; Pseudomonas exotoxin A; ricin toxin immunotoxin; cancer therapy; clinical trials; monoclonal antibody; Pseudomonas exotoxin A; ricin toxin
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Becker, N.; Benhar, I. Antibody-Based Immunotoxins for the Treatment of Cancer. Antibodies 2012, 1, 39-69.

AMA Style

Becker N, Benhar I. Antibody-Based Immunotoxins for the Treatment of Cancer. Antibodies. 2012; 1(1):39-69.

Chicago/Turabian Style

Becker, Nurit; Benhar, Itai. 2012. "Antibody-Based Immunotoxins for the Treatment of Cancer." Antibodies 1, no. 1: 39-69.

Antibodies EISSN 2073-4468 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert