Special Issue "Feature Paper 2013"
A special issue of Antibiotics (ISSN 2079-6382).
Deadline for manuscript submissions: closed (31 October 2013)
Prof. Dr. Christopher C. Butler
Institute of Primary Care & Public Health, Cardiff University, 3rd Floor, Neuadd Meirionnydd, Heath Park, Cardiff, CF14 4XN, UK
Phone: +44 2920 687168
Fax: +44 2920 687219
Interests: antibiotic use; common infections; antibiotic resistance; clinical trials; observational studies; qualitative research
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed Open Access quarterly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. For the first couple of issues the Article Processing Charge (APC) will be waived for well-prepared manuscripts. English correction and/or formatting fees of 250 CHF (Swiss Francs) will be charged in certain cases for those articles accepted for publication that require extensive additional formatting and/or English corrections.
Antibiotics 2013, 2(4), 465-476; doi:10.3390/antibiotics2040465
Received: 12 September 2013; in revised form: 17 October 2013 / Accepted: 31 October 2013 / Published: 5 November 2013| Download PDF Full-text (479 KB) | Download XML Full-text
Article: Low Request of Antibiotics from Patients with Respiratory Tract Infections in Six Countries: Results from the Happy Audit Study
Antibiotics 2013, 2(4), 477-484; doi:10.3390/antibiotics2040477
Received: 22 September 2013; in revised form: 13 November 2013 / Accepted: 13 November 2013 / Published: 19 November 2013| Download PDF Full-text (552 KB) | Download XML Full-text
Article: Influence of Sterilized Human Fecal Extract on the Sensitivity of Salmonella enterica ATCC 13076 and Listeria monocytogenes ATCC 15313 to Enrofloxacin
Antibiotics 2013, 2(4), 485-499; doi:10.3390/antibiotics2040485
Received: 1 August 2013; in revised form: 14 November 2013 / Accepted: 20 November 2013 / Published: 2 December 2013| Download PDF Full-text (932 KB) | Download XML Full-text
Antibiotics 2013, 2(4), 500-534; doi:10.3390/antibiotics2040500
Received: 13 September 2013; in revised form: 28 November 2013 / Accepted: 29 November 2013 / Published: 6 December 2013| Download PDF Full-text (895 KB) | Download XML Full-text
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Type of the Paper: Article
Title: Laboratory simulation of the effects of an initial antibiotic treatment on a subsequent therapy after initial therapy failure
Authors: Yanfang Feng, Nadine Handel, Marnix de Groot, Stanley Brul, Constance Schultz and Benno H. ter Kuile
Affiliations: University of Amsterdam, Amsterdam, The Netherlands
Abstract: Therapy failure of antibiotic treatment prescribed by a primary care physician occurs commonly. Anecdotal observations by medical microbiologists suggest that subsequent therapy may be hampered by resistance induced by the first treatment. Resistance to amoxicillin was rapidly induced at concentrations expected in the patient’s body. Strains made mildly resistant in this way outcompeted the wild-type whenever antibiotics, even in low concentrations, were present. The pre-treatment with amoxicillin also made the cells resistant to cefotaxime. The combined evidence suggests that the initial treatment by amoxicillin has a negative effect on subsequent therapy with beta-lactam antibiotics.
Title: Metabolic monitoring of streptomyces sp. MBT70 influenced by cultural conditions using NMR-based metabolomics
Authors: Hua Zhu, Changsheng Wu, Stephanie Sandiford, Young Hae Choi and Gilles P. van Wezel
Abstract:Streptomycetes are among the most versatile producers of new bioactive compounds. The production of secondary metabolites is greatly influenced by culturing conditions, and obtaining better insight into the correlation between growth conditions and productivity is important for screening purposes. Here we analyse the antibiotic-producing capacity of the novel Streptomyces species MBT70, and correlate the bioactivity to the metabolome by nuclear magnetic resonance (NMR)-based metabolomics. MBT70 is an ideal model system as it produces different antibiotics with activity against multi-drug resistant clinical isolates, which are expressed under specific conditions. Principal component analysis was performed on cultures grown in five different media. Different supervised data reduction algorithms were tested and compared, so as to highlight the metabolite variance correlating to antimicrobial activity. As a next step to obtain a more detailed correlation between metabolite production and growth conditions, partial least squares-discriminant analysis and orthogonal projection to latent structures were used to discriminate between the different bioactivities. Using 2D NMR techniques (J-resolved, 1H-1H COSY, HMBC and HMQC), several inducible antibiotics and other secondary metabolites were identified. Our work highlights NMR-based metabolomics as an effective tool to monitor the activation of poorly expressed antibiotics produced by Streptomyces.
Last update: 9 October 2013