Table of Contents
Toxics, Volume 6, Issue 2 (June 2018)
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Cover Story (view full-size image) DNA adducts, the covalent modifications of DNA, are biomarkers and molecular dosimeters reflecting [...] Read more. DNA adducts, the covalent modifications of DNA, are biomarkers and molecular dosimeters reflecting the exposure of genotoxicants. Formalin-fixed paraffin-embedded (FFPE) tissue is an alternative source to the otherwise limited fresh-frozen biopsy samples. FFPE has been widely used in genomics and proteomics, but largely underutilized in DNA adduct analyses. This review covers the formation of DNA adducts, followed by an overview of the formalin fixation process, and the measurement of DNA adducts in FFPE tissues, particularly by liquid chromatography-mass spectrometry. This technology can advance molecular epidemiology studies that seek to assess the causal role of environmental chemicals in cancer etiology. View the paper here.