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Toxics 2018, 6(2), 21; https://doi.org/10.3390/toxics6020021

Transcriptomic Analysis of Gonadal Adipose Tissue in Male Mice Exposed Perinatally to 2,2′,4,4′-Tetrabromodiphenyl Ether (BDE-47)

Department of Environmental Health Sciences, University of Massachusetts Amherst, 686 N. Pleasant St., 149A Goessmann, Amherst, MA 01003, USA
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Received: 7 March 2018 / Revised: 21 March 2018 / Accepted: 23 March 2018 / Published: 29 March 2018
(This article belongs to the Special Issue Polyhalogenated Aromatic Hydrocarbons)
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Abstract

For the majority of lipophilic compounds, adipose tissue is traditionally considered as a storage depot and only rarely as a target organ. Meanwhile, abnormalities in adipose tissue physiology induced by chemical exposure may contribute to the current epidemic of obesity and metabolic diseases. Polybrominated diphenyl ethers (PBDEs) are a group of lipophilic flame retardants found in the majority of human samples in North America. Their ability to alter the physiology of adipose tissue is unknown. We exposed pregnant mice to 0.2 mg/kg body weight/day of BDE-47 perinatally. Transcriptomic changes in gonadal adipose tissue were analyzed in male offspring using the RNA-seq approach with subsequent bioinformatic analysis. The expression of genes of coagulation and complement cascade, de novo lipogenesis, and xenobiotic metabolism was altered in response to BDE-47 exposure. The affected molecular network included the following hubs: PPARα, HNF1A, and HNF4. These findings suggest that adipose tissue should be considered a target tissue for BDE-47, in addition to its role as a storage depot. This study also builds a background for a targeted search of sensitive phenotypic endpoints of BDE-47 exposure, including lipid profile parameters and coagulation factors in circulation. Additional studies are needed to investigate the role of PBDEs as an obesogen. View Full-Text
Keywords: polybrominated diphenyl ether; PBDE; BDE-47; adipose; transcriptomic; genomic; obesogen; complement and coagulation cascade; de novo lipogenesis; metabolism polybrominated diphenyl ether; PBDE; BDE-47; adipose; transcriptomic; genomic; obesogen; complement and coagulation cascade; de novo lipogenesis; metabolism
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Abrha, A.; Suvorov, A. Transcriptomic Analysis of Gonadal Adipose Tissue in Male Mice Exposed Perinatally to 2,2′,4,4′-Tetrabromodiphenyl Ether (BDE-47). Toxics 2018, 6, 21.

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