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Toxics 2018, 6(2), 33; https://doi.org/10.3390/toxics6020033

The Toxic Effect of Lanthanum on Planaria Is Mediated by a Variety of Ion Channels

College of Health Human Service and Sciences, Ashford University, San Diego, CA 92123, USA
Received: 27 April 2018 / Revised: 11 June 2018 / Accepted: 13 June 2018 / Published: 18 June 2018
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Abstract

The effect of toxic concentrations of La3+ on the Ca, K, Na, Mg, and Cl channels of planaria was investigated through the use of various agonists and antagonists to those channels. It was demonstrated that La exerts its toxic effects through L-type, but not T-type, Ca channels. La also demonstrated activity at Na, K, Mg, and Cl channels, but, these effects were most likely mediated by other effects of La on Ca activity. However, these interactions appear to be very complex and confounded by oxidative stresses. The study also introduces a planaria stress scale which allows the effects of toxic substances to be examined on a continuum. View Full-Text
Keywords: lanthanum; planaria; toxicology; calcium; ion channels; potassium; sodium; chloride; magnesium lanthanum; planaria; toxicology; calcium; ion channels; potassium; sodium; chloride; magnesium
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Briner, W. The Toxic Effect of Lanthanum on Planaria Is Mediated by a Variety of Ion Channels. Toxics 2018, 6, 33.

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