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Nutrients 2013, 5(5), 1706-1718; doi:10.3390/nu5051706

Genome-Wide Association Study of Serum Selenium Concentrations

1 Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA 2 Department of Biostatistics, University of Washington, Seattle, WA 98195, USA 3 Department of Internal Medicine, University of New Mexico, Albuquerque, NM 87131, USA 4 Department of Pharmacy, University of Copenhagen, Copenhagen, DK-2100, Denmark 5 Translational Genomics Research Institute, Phoenix, AZ 85004, USA 6 Stephens and Associates, Carrollton, TX 75006, USA 7 Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, MD 20892, USA 8 Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA 9 Center for Primary Care and Prevention, Memorial Hospital of Rhode Island, Pawtucket, RI 02860, USA 10 Department of Health Behavior, Roswell Park Cancer Institute, Buffalo, NY 14263, USA 11 Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA 98195, USA
* Author to whom correspondence should be addressed.
Received: 2 February 2013 / Revised: 2 May 2013 / Accepted: 9 May 2013 / Published: 21 May 2013
(This article belongs to the Special Issue Dietary Selenium and Health)
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Selenium is an essential trace element and circulating selenium concentrations have been associated with a wide range of diseases. Candidate gene studies suggest that circulating selenium concentrations may be impacted by genetic variation; however, no study has comprehensively investigated this hypothesis. Therefore, we conducted a two-stage genome-wide association study to identify genetic variants associated with serum selenium concentrations in 1203 European descents from two cohorts: the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening and the Women’s Health Initiative (WHI). We tested association between 2,474,333 single nucleotide polymorphisms (SNPs) and serum selenium concentrations using linear regression models. In the first stage (PLCO) 41 SNPs clustered in 15 regions had p < 1 × 10−5. None of these 41 SNPs reached the significant threshold (p = 0.05/15 regions = 0.003) in the second stage (WHI). Three SNPs had p < 0.05 in the second stage (rs1395479 and rs1506807 in 4q34.3/AGA-NEIL3; and rs891684 in 17q24.3/SLC39A11) and had p between 2.62 × 10−7 and 4.04 × 10−7 in the combined analysis (PLCO + WHI). Additional studies are needed to replicate these findings. Identification of genetic variation that impacts selenium concentrations may contribute to a better understanding of which genes regulate circulating selenium concentrations.
Keywords: selenium; serum; selenoprotein; genome-wide association study; AGA; NEIL3; SLC39A11 selenium; serum; selenoprotein; genome-wide association study; AGA; NEIL3; SLC39A11
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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Gong, J.; Hsu, L.; Harrison, T.; King, I.B.; Stürup, S.; Song, X.; Duggan, D.; Liu, Y.; Hutter, C.; Chanock, S.J.; Eaton, C.B.; Marshall, J.R.; Peters, U. Genome-Wide Association Study of Serum Selenium Concentrations. Nutrients 2013, 5, 1706-1718.

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