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Nutrients 2013, 5(4), 1349-1365; doi:10.3390/nu5041349
Review

Selenium Supranutrition: Are the Potential Benefits of Chemoprevention Outweighed by the Promotion of Diabetes and Insulin Resistance?

 and *
Department of Nutrition and Food Science, University of Maryland, College Park, MD 20742, USA
* Author to whom correspondence should be addressed.
Received: 5 March 2013 / Revised: 5 April 2013 / Accepted: 7 April 2013 / Published: 19 April 2013
(This article belongs to the Special Issue Dietary Selenium and Health)
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Abstract

Selenium was considered a toxin until 1957, when this mineral was shown to be essential in the prevention of necrotic liver damage in rats. The hypothesis of selenium chemoprevention is principally formulated by the observations that cancer incidence is inversely associated with selenium status. However, recent clinical and epidemiological studies demonstrate a role for some selenoproteins in exacerbating or promoting other disease states, specifically type 2 diabetes, although other data support a role of selenium in stimulating insulin sensitivity. Therefore, it is clear that our understanding in the role of selenium in glucose metabolism and chemoprevention is inadequate and incomplete. Research exploring the role of selenium in individual healthcare is of upmost importance and possibly will help explain how selenium is a double-edged sword in the pathologies of chronic diseases.
Keywords: selenium; supranutrition; type 2 diabetes; cancer selenium; supranutrition; type 2 diabetes; cancer
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Rocourt, C.R.B.; Cheng, W.-H. Selenium Supranutrition: Are the Potential Benefits of Chemoprevention Outweighed by the Promotion of Diabetes and Insulin Resistance? Nutrients 2013, 5, 1349-1365.

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