Nutrients 2013, 5(4), 1349-1365; doi:10.3390/nu5041349
Review

Selenium Supranutrition: Are the Potential Benefits of Chemoprevention Outweighed by the Promotion of Diabetes and Insulin Resistance?

Department of Nutrition and Food Science, University of Maryland, College Park, MD 20742, USA
* Author to whom correspondence should be addressed.
Received: 5 March 2013; in revised form: 5 April 2013 / Accepted: 7 April 2013 / Published: 19 April 2013
(This article belongs to the Special Issue Dietary Selenium and Health)
PDF Full-text Download PDF Full-Text [550 KB, uploaded 19 April 2013 13:44 CEST]
Abstract: Selenium was considered a toxin until 1957, when this mineral was shown to be essential in the prevention of necrotic liver damage in rats. The hypothesis of selenium chemoprevention is principally formulated by the observations that cancer incidence is inversely associated with selenium status. However, recent clinical and epidemiological studies demonstrate a role for some selenoproteins in exacerbating or promoting other disease states, specifically type 2 diabetes, although other data support a role of selenium in stimulating insulin sensitivity. Therefore, it is clear that our understanding in the role of selenium in glucose metabolism and chemoprevention is inadequate and incomplete. Research exploring the role of selenium in individual healthcare is of upmost importance and possibly will help explain how selenium is a double-edged sword in the pathologies of chronic diseases.
Keywords: selenium; supranutrition; type 2 diabetes; cancer

Article Statistics

Load and display the download statistics.

Citations to this Article

Cite This Article

MDPI and ACS Style

Rocourt, C.R.B.; Cheng, W.-H. Selenium Supranutrition: Are the Potential Benefits of Chemoprevention Outweighed by the Promotion of Diabetes and Insulin Resistance? Nutrients 2013, 5, 1349-1365.

AMA Style

Rocourt CRB, Cheng W-H. Selenium Supranutrition: Are the Potential Benefits of Chemoprevention Outweighed by the Promotion of Diabetes and Insulin Resistance? Nutrients. 2013; 5(4):1349-1365.

Chicago/Turabian Style

Rocourt, Caroline R.B.; Cheng, Wen-Hsing. 2013. "Selenium Supranutrition: Are the Potential Benefits of Chemoprevention Outweighed by the Promotion of Diabetes and Insulin Resistance?" Nutrients 5, no. 4: 1349-1365.

Nutrients EISSN 2072-6643 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert